全文获取类型
收费全文 | 4000篇 |
免费 | 166篇 |
国内免费 | 463篇 |
专业分类
化学 | 3485篇 |
晶体学 | 7篇 |
力学 | 340篇 |
综合类 | 68篇 |
数学 | 135篇 |
物理学 | 594篇 |
出版年
2024年 | 9篇 |
2023年 | 46篇 |
2022年 | 272篇 |
2021年 | 248篇 |
2020年 | 157篇 |
2019年 | 152篇 |
2018年 | 145篇 |
2017年 | 149篇 |
2016年 | 240篇 |
2015年 | 196篇 |
2014年 | 185篇 |
2013年 | 307篇 |
2012年 | 201篇 |
2011年 | 171篇 |
2010年 | 135篇 |
2009年 | 158篇 |
2008年 | 140篇 |
2007年 | 199篇 |
2006年 | 197篇 |
2005年 | 159篇 |
2004年 | 156篇 |
2003年 | 136篇 |
2002年 | 118篇 |
2001年 | 109篇 |
2000年 | 72篇 |
1999年 | 77篇 |
1998年 | 44篇 |
1997年 | 58篇 |
1996年 | 64篇 |
1995年 | 41篇 |
1994年 | 50篇 |
1993年 | 33篇 |
1992年 | 47篇 |
1991年 | 28篇 |
1990年 | 28篇 |
1989年 | 21篇 |
1988年 | 18篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 12篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有4629条查询结果,搜索用时 15 毫秒
81.
采用UMT-2型微摩擦磨损试验机考察了4种纳米颗粒LaF3、Ag、SiO2 及Al2O3作为润滑油添加剂在摩擦过程中的接触电阻随时间变化的情况,并由此监测摩擦副表面的成膜状况;采用X射线光电子能谱仪分析4种纳米添加剂润滑下磨损表面典型元素的化学状态,并结合接触电阻测试结果分析纳米油润滑添加剂的润滑机理.结果表明:接触电阻测试能够适时监测添加剂在摩擦副表面的成膜过程,4种纳米润滑油添加剂在边界润滑条件下均能够在磨损表面沉积成膜,其在试验过程中的化学状态没有发生变化,但4种纳米润滑油添加剂在摩擦过程中的成膜性能不同,Ag和LaF3在摩擦过程中的沉积速率、沉积膜厚度及其在摩擦副表面的结合强度优于SiO2和Al2O3. 相似文献
82.
采用改进的碱液萃取方法分离杜巴原油中的酸性化合物(主要是环烷酸),通过高分辨质谱分析萃取过程中不同组分酸性化合物组成,以研究碱萃取前后酸性化合物的分布与组成特征。实验结果表明,电喷雾傅立叶变换离子回旋共振高分辨质谱(ESI-FT-ICR-MS)是分析原油中酸性化合物的强有力的手段;酸性化合物分布于碱萃取前后的各个组分中,但其组成有明显的差异,碱液萃取出的石油酸主要是相对分子质量小于500的酸性组分,增加反萃取溶剂的用量和极性有利于脱除萃取物中的非碱性氮化合物,对石油羧酸的组成影响不大。 相似文献
83.
A turnout switch machine is key equipment in a railway, and its fault condition has an enormous impact on the safety of train operation. Electrohydraulic switch machines are increasingly used in high-speed railways, and how to extract effective fault features from their working condition monitoring signal is a difficult problem. This paper focuses on the sectionalized feature extraction method of the oil pressure signal of the electrohydraulic switch machine and realizes the fault detection of the switch machine based on this method. First, the oil pressure signal is divided into three stages according to the working principle and action process of the switch machine, and multiple features of each stage are extracted. Then the max-relevance and min-redundancy (mRMR) algorithm is applied to select the effective features. Finally, the mini batch k-means method is used to achieve unsupervised fault diagnosis. Through experimental verification, this method can not only derive the best sectionalization mode and feature types of the oil pressure signal, but also achieve the fault diagnosis and the prediction of the status of the electrohydraulic switch machine. 相似文献
84.
85.
采用水蒸气蒸馏法提取了冷蒿挥发油,气相色谱-质谱联用结合计算机检索对其化学成分进行了分析和鉴定,共分离出106个峰,确定了101种化合物,它们主要是二甲基-甲撑基环庚(17.67%)、3,3,6-三甲基-1,5-庚二烯醇-2(16.40%)、3,3,6-三甲基-1,4-庚二烯醇-6(8.55%)、桉树脑(5.57%)、3,7-二甲-基2,6-辛二烯醇-1(3.85%)、神圣亚麻三烯(3.73%)、1-甲基-3-异丙基苯(3.26%)、桥环[2,2,1]萜烯(2.91%)、樟脑(2.26%)、香叶烯(2.20%),以上10种化合物占挥发油总量的66.40%。 相似文献
86.
采用水蒸气蒸馏法提取,运用气相色谱-质谱联用法对香叶蒿挥发油化学成分进行了分析,用气相色谱面积归一化法测定了各成分的质量分数。结果鉴定出72个化合物,主要成分为樟脑(33.136%),桉树脑(23.419%),6-甲基-2-乙烯基-1,3-庚二烯醛(8.414%),孟烯醇(3.819%),桥环萜烯酮(3.276%),莰烯(2.454%),1R-α-蒎烯(1.917%),去甲基丁香酚(1.550%),α-松油醇(1.449%),冰片(1.674%),β-香叶烯(1.165%),百里香酚(0.329%)等。研究表明紫花冷蒿挥发油主要为单萜及其氧化衍生物。其挥发油成分的研究为挖掘其药用及食品香料工业的应用价值提供了科学依据。 相似文献
87.
Valentina Noemi Madia Walter Toscanelli Daniela De Vita Marta De Angelis Antonella Messore Davide Ialongo Luigi Scipione Valeria Tudino Felicia Diodata DAuria Roberto Di Santo Stefania Garzoli Annarita Stringaro Marisa Colone Magda Marchetti Fabiana Superti Lucia Nencioni Roberta Costi 《Molecules (Basel, Switzerland)》2022,27(12)
Influenza viruses are transmitted from human to human via airborne droplets and can be transferred through contaminated environmental surfaces. Some works have demonstrated the efficacy of essential oils (EOs) as antimicrobial and antiviral agents, but most of them examined the liquid phases, which are generally toxic for oral applications. In our study, we describe the antiviral activity of Citrus bergamia, Melaleuca alternifolia, Illicium verum and Eucalyptus globulus vapor EOs against influenza virus type A. In the vapor phase, C. bergamia and M. alternifolia strongly reduced viral cytopathic effect without exerting any cytotoxicity. The E. globulus vapor EO reduced viral infection by 78% with no cytotoxicity, while I. verum was not effective. Furthermore, we characterized the EOs and their vapor phase by the head-space gas chromatography–mass spectrometry technique, observing that the major component found in each liquid EO is the same one of the corresponding vapor phases, with the exception of M. alternifolia. To deepen the mechanism of action, the morphological integrity of virus particles was checked by negative staining transmission electron microscopy, showing that they interfere with the lipid bilayer of the viral envelope, leading to the decomposition of membranes. We speculated that the most abundant components of the vapor EOs might directly interfere with influenza virus envelope structures or mask viral structures important for early steps of viral infection. 相似文献
88.
Robson Araújo de Freitas Junior Paloma Kênia de Moraes Berenguel Lossavaro Cndida Aparecida Leite Kassuya Edgar Julian Paredes-Gamero Nelson Carvalho Farias Júnior Maria Inês Lenz Souza Francielli Maria de Souza Silva-Comar Roberto Kenji Nakamura Cuman Denise Brentan Silva Mnica Cristina Toffoli-Kadri Saulo Euclides Silva-Filho 《Molecules (Basel, Switzerland)》2022,27(12)
The aim of this study is to evaluate the phytochemical profile, oral acute toxicity, and the effect of ylang-ylang (Cananga odorata Hook. F. & Thomson) essential oil (YEO) on acute inflammation. YEO was analyzed by gas chromatography/mass spectrometry. For in vitro tests, YEO was assessed using cytotoxicity, neutrophil chemotaxis induced by N-formyl methionyl leucyl phenylalanine (fMLP), and phagocytic activity tests. YEO was orally administered in zymosan-induced peritonitis, carrageenan-induced leukocyte rolling, and adhesion events in the in situ microcirculation model and in carrageenan-induced paw edema models. YEO (2000 mg/kg) was also tested using an acute toxicity test in Swiss mice. YEO showed a predominance of benzyl acetate, linalool, benzyl benzoate, and methyl benzoate. YEO did not present in vitro cytotoxicity. YEO reduced the in vitro neutrophil chemotaxis induced by fMLP and reduced the phagocytic activity. The oral treatment with YEO reduced the leukocyte recruitment and nitric oxide production in the zymosan-induced peritonitis model, reduced rolling and adherent leukocyte number induced by carrageenan in the in situ microcirculation model, and reduced carrageenan-induced edema and mechanical hyperalgesia. YEO did not present signs of toxicity in the acute toxicity test. In conclusion, YEO affected the leukocyte activation, and presented antiedematogenic, anti-hyperalgesic, and anti-inflammatory properties. 相似文献
89.
Hansel E. Gonzlez-Velasco María S. Prez-Gutirrez ngel J. Alonso-Castro Juan R. Zapata-Morales Perla del C. Nio-Moreno Nimsi Campos-Xolalpa Marco M. Gonzlez-Chvez 《Molecules (Basel, Switzerland)》2022,27(9)
Tagetes parryi is a plant empirically used to treat gastrointestinal and inflammatory diseases, its essential oil (EOTP) was obtained from the aerial parts, and the composition was elucidated by GC-MS. The in vivo and in vitro anti-inflammatory activities and the antinociceptive activity of EOTP and (1S)-(-)-verbenone (VERB) were assessed. The major compounds identified for EOTP were verbenone (33.39%), dihydrotagetone (26.88%), and tagetone (20.8%). EOTP and VERB diminished the ear oedema induced with TPA by 93.77 % and 81.13 %, respectively. EOTP and VERB decreased inflammation in a 12-O-tetradecanoylphorbol-13-acetate (TPA) chronic model with ED50 = 54.95 mg/kg and 45.24 mg/kg, respectively. EOTP (15 µg/mL) inhibited the in vitro production of the pro-inflammatory mediators NO (67.02%), TNF-α (69.21%), and IL-6 (58.44%) in LPS-stimulated macrophages. In the acetic induced writhing test, EOTP and VERB showed antinociceptive effects with ED50 = 84.93 mg/kg and ED50 = 45.24 mg/kg, respectively. In phase 1 of the formalin test, EOTP and VERB showed no antinociceptive effects, whereas in phase 2, EOTP (ED50 = 35.45 mg/kg) and VERB (ED50 = 24.84 mg/kg) showed antinociceptive effects. The antinociceptive actions of ETOP and VERB were blocked with the co-administration of L-NAME. This study suggests that EOTP and VERB might be used in the treatment of pain and inflammatory problems. 相似文献
90.
Sarra Akermi Slim Smaoui Khaoula Elhadef Mariam Fourati Nacim Louhichi Moufida Chaari Ahlem Chakchouk Mtibaa Aissette Baanannou Saber Masmoudi Lotfi Mellouli 《Molecules (Basel, Switzerland)》2022,27(9)
Nowadays, increasing interest has recently been given to the exploration of new food preservatives to avoid foodborne outbreaks or food spoilage. Likewise, new compounds that substitute the commonly used synthetic food preservatives are required to restrain the rising problem of microbial resistance. Accordingly, the present study was conducted to examine the chemical composition and the mechanism(s) of action of the Cupressus sempervirens essential oil (CSEO) against Salmonella enterica Typhimuriumand Staphyloccocus aureus. The gas chromatography analysis revealed α-pinene (38.47%) and δ-3-carene (25.14%) are the major components of the CSEO. By using computational methods, such as quantitative structure–activity relationship (QSAR), we revealed that many CSEO components had no toxic effects. Moreover, findings indicated that α-pinene, δ-3-carene and borneol, a minor compound of CSEO, could inhibit the AcrB-TolC and MepR efflux pump activity of S. enterica Typhimurium and S. aureus, respectively. In addition, our molecular docking predictions indicated the high affinity of these three compounds with active sites of bacterial DNA and RNA polymerases, pointing to plausible impairments of the pathogenic bacteria cell replication processes. As well, the safety profile was developed through the zebrafish model. The in vivo toxicological evaluation of (CSEO) exhibited a concentration-dependent manner, with a lethal concentration (LC50) equal to 6.6 µg/mL. 相似文献