LaCaMnO3 thin film laser energy/power meter

A prototype laser energy/power meter was designed based on the anisotropic Seebeck effect of LaCaMnO₃ thin film grown on vicinal cut LaAlO₃ substrate. The optical response of this device to the pulsed laser and the chopped CW laser was measured from infrared to ultraviolet. The peak voltage of the measured signal shows a good linear relation to the laser energy and power in the measured range. It was shown that at 1064 nm wavelength, this prototype device demonstrates higher sensitivity than that of commercial device.     

pH Readout enhanced ELISA for point-of-care testing of cardiac troponin I

In this study, we described a pH ELISA using synthetic melanin nanoparticles (SMNPs) for the co-immobilization of glucose oxidase and second antibody as signal labels, portable pH meter as signal readout device for detecting biomarker of myocardial injury. This assay is easy-to-use, portable, sensitive and able to realize point-of-care testing (POCT), which was demonstrated the signifi cant promising in the early diagnosis and screening of acute myocardial infarction.     

蒙特卡洛法评定在线pH计示值误差的不确定度

以在线p H计为例,考察了在线酸度计示值误差不确定度的分布规律,利用蒙特卡洛法评定示值误差不确定度。对于0.01级的在线p H计,蒙特卡洛法与GUM法评定结果的差值为9.1%,小于不可靠性(20%);对于0.1级的在线p H计,蒙特卡洛法与GUM法评定结果的差值为3.8%,小于不可靠性(10%)。通过比较得出结论,采用GUM法验证了蒙特卡洛法(MCM)根据JJF 1547–2015评定在线p H计示值误差不确定度的方法是有效且适用的。尤其在测量模型非线性以及输出量的概率密度函数(PDF)较大程度地偏离正态分布或t分布等GUM法不适用的场合,蒙特卡洛法是评定在线分析监测仪器仪表示值误差不确定度的重要手段。     

透光率计滤光片标准物质的研制

以中性灰玻璃及特种石英玻璃为材料,采用切割、研磨、抛光等工艺,制备了校准透光率计用系列滤光片标准物质,标准物质的均匀性不确定度为0.08%,校准周期内的稳定性不确定度为0.19%,扩展不确定度为0.5%(k=2)。该标准物质可广泛用于校准透光率计,具有携带方便、性能稳定等优点。     

应用多传感器时间融合的塞状流测量研究

气液两相流由于其自身的复杂性,流型、流量等流动参数的测量一直是研究的重点和难点.应用多传感器数据融合技术测量气液两相流可以从多角度揭示流体信息,提高流动参数的测量精度.多传感器系统主要由截面信息测量系统和V型内锥式流量计构成,在利用相关技术对截面测量信息与V型内锥式流量计的测量数据进行时间融合的基础上,对水平管气液塞状流经行了分段式的流量测量.测量中将气塞和液塞分开计算,并引入了等效干度的计算,通过对实验结果进行的误差比较,验证了该方法是可行的,而且能一定程度上提高测量精度.     

基于热敏电阻温度特性的拓展实验系列研究

介绍了应用于大学物理实验教学实验中的热敏电阻温度特性实验及拓展实验系列．基于“热电阻铂和NTC热敏电阻温度特性研究”这一设计性实验,给出了相关的3个拓展实验：选择合适的元件将微安表改装成温度表,并确定测温量程范围;对电路进行改进,用铂热电阻制作热电阻式流量计;利用NTC热敏电阻温度传感器和运算放大器,对电路作进一步拓展,制作医用电子体温计．     

Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose

As a key enzyme regulating postprandial blood glucose, α-Glucosidase is considered to be an effective target for the treatment of diabetes mellitus. In this study, a simple, rapid, and effective method for enzyme inhibitors screening assay was established based on α-glucosidase catalyzes reactions in a personal glucose meter (PGM). α-glucosidase catalyzes the hydrolysis of maltose to produce glucose, which triggers the reduction of ferricyanide (K₃[Fe(CN)₆]) to ferrocyanide (K₄[Fe(CN)₆]) and generates the PGM detectable signals. When the α-glucosidase inhibitor (such as acarbose) is added, the yield of glucose and the readout of PGM decreased accordingly. This method can achieve the direct determination of α-glucosidase activity by the PGM as simple as the blood glucose tests. Under the optimal experimental conditions, the developed method was applied to evaluate the inhibitory activity of thirty-four small-molecule compounds and eighteen medicinal plants extracts on α-glucosidase. The results exhibit that lithospermic acid (52.5 ± 3.0%) and protocatechualdehyde (36.8 ± 2.8%) have higher inhibitory activity than that of positive control acarbose (31.5 ± 2.5%) at the same final concentration of 5.0 mM. Besides, the lemon extract has a good inhibitory effect on α-glucosidase with a percentage of inhibition of 43.3 ± 3.5%. Finally, the binding sites and modes of four active small-molecule compounds to α-glucosidase were investigated by molecular docking analysis. These results indicate that the PGM method is feasible to screening inhibitors from natural products with simple and rapid operations.     

用于高压电能表的新型电源管理单元设计

新型高压电能表具有计量精度高、低功耗、信息化、智能化等优点,获得了越来越多的应用。论文对新型电能表计量装置的供电需求进行了探讨,在此基础上设计了一基于感应电流取能的新型电源管理单元,在稳压器输入端增加了电能智能存储功能,确保在极端工作条件下,电能表仍具有计量、数据存储、无线抄收等功能,避免了因利用该技术出现断电及断电重启时刻导致的计量损失。测试结果表明,电源管理单元能够确保电能表在极端情况下稳定工作4.5小时。     

在线超声波流量监测系统设计及其应用

为解决地源热泵系统中的进出水流量测量,设计研究基于超声波时差法原理的非接触式在线流量监测装置。系统以STM32F407 ZE为主控制器,定时采集流量、完成数据封包、加密和远端服务器交互任务;以MSP430F2618为流量测量控制器,采用时差法以TDC-GP22精准测量超声波在介质中传播时间,实现管道流体流速、流量实时监测。系统测试结果实现流量数据测量及上传存储到远端服务器,满足地源热泵系统流量监测需求。     

浆氮电容式密度计及液位计的实验研究

采用电容式密度计及液位计来测量浆氮密度及液位的变化,使用整体屏蔽法对测量系统进行保护以减小寄生电容并提高其抗干扰能力。从理论上分析整体屏蔽法在提高测量系统性能上的作用,并通过实验加以验证。在实验中对密度计和液位计进行标定以提高其测量的精度,并使用密度计测量制备过程中浆氮密度的变化情况。