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51.
Dr. Jagadeesh Yerri Dr. José Dias Dr. Mallikajurna Reddy Nimmakayala Franck Razafindrainibe Charlotte Courageux Anne-Julie Gastellier Johanne Jegoux Dr. Caroline Coisne Dr. Christophe Landry Dr. Fabien Gosselet Johan Hachani Dr. Jean-François Goossens Prof. Marie-Pierre Dehouck Dr. Florian Nachon Dr. Rachid Baati 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(65):15035-15044
Novel 6-alkyl- and 6-alkenyl-3-fluoro-2-pyridinaldoximes have been synthesised by using a mild and efficient chemoselective hydrogenation of 6-alkynyl-3-fluoro-2-pyridinaldoxime scaffolds, without altering the reducible, unprotected, sensitive oxime functionality and the C−F bond. These novel 6-alkyl-3-fluoro-2-pyridinaldoximes may find medicinal application as antidotes to organophosphate poisoning. Indeed, one low-molecular-weight compound exhibited increased affinity for sarin-inhibited acetylcholinesterase (hAChE) and greater reactivation efficiency or resurrection for sarin-inhibited hAChE, compared with those of 2-pyridinaldoxime (2-PAM) and 1-({[4-(aminocarbonyl)pyridinio]methoxy}methyl)-2-[(hydroxyimino)methyl]pyridinium chloride (HI-6), two pyridinium salts currently used as antidote by several countries. In addition, the uncharged 3-fluorinated bifunctional hybrid showed increased in vitro blood–brain barrier permeability compared with those of 2-PAM, HI-6 and obidoxime. These promising features of novel low-molecular-weight alkylfluoropyridinaldoxime open up a new era for the design, synthesis and discovery of central non-quaternary broad spectrum reactivators for organophosphate-inhibited cholinesterases. 相似文献
52.
Use of nanocomposites is a well-established approach in enhancing the mechanical and barrier properties of bionanocomposite film for food packaging applications. The seed mucilage of Ocimum basilicum was employed for the preparation of bionanocomposite films with montmorillonite (MMT) as nanofiller. The films were prepared by solvent-casting method at varied solution pH (1, 3, 5 and 9) and MMT loading (1%, 3%, 5%, 10%, 15% and 20%). The films were characterized for physical, mechanical and barrier properties in addition to microstructure and X-ray diffraction pattern. XRD analysis revealed the exfoliated dispersion of MMT at pH 9, confirming its effective interaction with the bionanocomposite film. Maximum film tensile strength was achieved at a lower MMT load of 5%. Water vapour permeability reduced with increase in MMT loading up to 5%, followed by an increase at higher MMT loadings. Film formed at pH 9 showed tensile strength of 17.3 ± 0.33 MPa and reduced water vapour permeability (WVP) of 0.21 g mm.m−2.hr−1.kPa−1. 相似文献
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Based on the governing equations of 2D plane-strain Biot’s consolidation, the relationship between generalized displacements and stresses of a single soil layer with anisotropic permeability and incompressible fluid and solid constituents is described by an analytical layer-element, which is deduced in the Laplace–Fourier transform domain by using the eigenvalue approach. Taking the boundary conditions and the continuity of the soil layers into consideration, a global stiffness matrix is subsequently assembled and solved. As to the 3D case, the same derivation is employed after the application of a decoupling transformation. The actual solutions in the physical domain can further be acquired by inverting the Laplace–Fourier transform. Finally, numerical examples are carried out to verify the presented theory and discuss the influence of the anisotropic permeability on the consolidation behavior. 相似文献
55.
The paper details the implementation of the Godunov‐type finite volume Arbitrary high order schemes using Derivatives (ADER) scheme for the case of a large source term in the continuity equation of the nonlinear shallow water equations. The particular application is the movement of a bore on a highly permeable slope. The large source term is caused by the infiltration into the initially unsaturated slope material. Infiltration is modelled as vertical downwards piston‐like flow with Forchheimer quadratic parameterisation of the resistance law. The corresponding ODE is solved using the fourth‐order Runge–Kutta method. The surface and subsurface flow models have been tested by comparison with analytical solutions. Example predictions of surface bore propagation and wetting front propagation are presented for a range of slope permeabilities. The effects of permeability on bore run‐up, water depths and velocities are illustrated. The ADER scheme is capable of handling the source term, including the extreme case when this term dominates the volume balance. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
56.
This paper reports the extension of earlier work (Dawar and Chandra, 2012) [27] by including the influence of low values of electric field on diffusion limited aggregation (DLA) patterns in polymer electrolyte composites. Subsequently, specified cut-off value of voltage has been determined. Below the cut-off voltage, the growth becomes direction independent (i.e., random) and gives rise to ramified DLA patterns while above the cut-off, growth is governed by diffusion, convection and migration. These three terms (i.e., diffusion, convection and migration) lead to structural transition that varies from dense branched morphology (DBM) to chain-like growth to dendritic growth, i.e., from high field region (A) to constant field region (B) to low field region (C), respectively. The paper further explores the growth under different kinds of electrode geometries (circular and square electrode geometry). A qualitative explanation for fractal growth phenomena at applied voltage based on Nernst–Planck equation has been proposed. 相似文献
57.
《Journal of Polymer Science.Polymer Physics》2018,56(7):558-575
Partially sulfonated poly(aryl ether sulfone) (PESS) was synthesized and methacrylated via reaction with glycidyl methacrylate (PESSGMA) and cross‐linked via radical polymerization with styrene and vinyl‐phosphonic acid (VPA). The chemical structures of the synthesized pre‐polymers were characterized via FTIR and 1H NMR spectroscopic methods and molecular weight was determined via GPC. Membranes of these polymers were prepared via solution casting method. The crosslinking of the PESS polymer reduced IEC, proton conductivity, swelling in water, and methanol permeability of the membranes while increasing the modulus and the glass transition temperature. However, the introduction of the VPA comonomer increased the proton conductivity while maintaining excellent resistance to methanol cross‐over, which was significantly higher as compared with both PESS and the commercial Nafion membranes. Membranes of PESSGMA copolymers incorporating VPA, exhibited proton conductivity values at 60 °C in the range of 16–32 mS cm−1 and methanol permeability values in the range of 6.52 × 10−9 – 1.92 × 10−8 cm2 s−1. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018 , 56, 558–575 相似文献
58.
H. Sardon A. González M.J. Fernández-Berridi 《Journal of Macromolecular Science: Physics》2015,54(6):711-721
The oxygen barrier properties of films obtained from waterborne polyurethane/silica hybrid dispersions were analyzed. Two different types of polyurethanes were used, based on poly(propylene glycol) and poly(1,4-butylene adipate). Three different strategies were followed in the preparation of the hybrid dispersions. In the first type of materials (series 1), the inorganic part came exclusively from the covalent incorporation of trifunctional silane groups into the polymeric chains. The other two series contained, in addition to the trifunctional silane groups, tetrafunctional silane groups either physically blended (series 2) or “in situ” generated (series 3). Materials of series 1 showed an increase of the oxygen permeability coefficient with the silane content. However, the other two types of materials presented just the opposite dependence. In this latter case, the systems containing “in situ” generated silica (series 3) presented higher permeability coefficient values, probably because of the steric hindrance imposed by the polyurethane that gave rise to silica networks containing silanol groups and free volume holes. Moreover, lower permeability coefficient values were obtained when larger size particles were added. This fact could mean that the polyurethane/silica interface effects were not totally hindered even when the organic/inorganic phases were covalently bonded. 相似文献
59.
Marco Cespi Luca Casettari Giulia Bonacucina Gianfabio Giorgioni Diego R Perinelli Giovanni Filippo Palmieri 《先进技术聚合物》2013,24(11):1018-1024
This paper deals with a new application of diblock methoxy polyethylene glycol‐polylactide block copolymers, a class of synthetic biomaterials largely studied in the pharmaceutical and biomedical fields owing to their favorable properties such as biocompatibility, biodegradability, low immunogenicity, and good mechanical properties. In this work, these materials were evaluated as additives for gastro‐soluble pharmaceutical coating aimed to reduce film stiffness and water permeability. Two copolymers with different polylactide chain lengths were synthesized and characterized in term of molecular weight and solid‐state properties. A series of free films with different hypromellose/copolymers ratio were prepared and characterized in terms of appearance, components miscibility, plasticity, and water vapor permeability. The obtained results demonstrate that copolymers effectively influence hypromellose film properties according to their concentration and molecular weight. Specifically, the addition of the copolymer with a molecular weight of 6.5 kDa in a ratio hypromellose:polymer 5:1, allowed to obtain films with good appearance, improved plasticization, and water permeability properties. For higher molecular weight, copolymer or different ratios was not possible to observe the improvement of all the properties at the same time. The results also make possible to define the critical features to improve in order to use block copolymers as additive in hypromellose film coating. The availability of new water‐soluble additives able to work as plasticizer and moisture sealer in polymeric films represents an important progress not only in the field of pharmaceutical coating but also in that of food coatings, as for example in the formulation of edible films. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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