Super-resolved parallel MRI by spatiotemporal encoding

Recent studies described an “ultrafast” scanning method based on spatiotemporal (SPEN) principles. SPEN demonstrates numerous potential advantages over EPI-based alternatives, at no additional expense in experimental complexity. An important aspect that SPEN still needs to achieve for providing a competitive ultrafast MRI acquisition alternative, entails exploiting parallel imaging algorithms without compromising its proven capabilities. The present work introduces a combination of multi-band frequency-swept pulses simultaneously encoding multiple, partial fields-of-view, together with a new algorithm merging a Super-Resolved SPEN image reconstruction and SENSE multiple-receiving methods. This approach enables one to reduce both the excitation and acquisition times of sub-second SPEN acquisitions by the customary acceleration factor R, without compromises in either the method’s spatial resolution, SAR deposition, or capability to operate in multi-slice mode. The performance of these new single-shot imaging sequences and their ancillary algorithms were explored and corroborated on phantoms and human volunteers at 3 T. The gains of the parallelized approach were particularly evident when dealing with heterogeneous systems subject to major T₂/T₂* effects, as is the case upon single-scan imaging near tissue/air interfaces.     

基于伪魏格纳分布分解的合成孔径雷达图像目标与阴影分割

在二维魏格纳分布的框架内,针对魏格纳变换的交叉项问题和计算量大的问题,提出了合成孔径雷达图像局部伪魏格纳变换的目标和目标阴影的分割方法.首先,将合成孔径雷达图像进行二维伪魏格纳变换,得到各像素点的二维能量谱图|然后提取各像素点的二维能量谱图对应位置值形成多个不同频段的与原图像同大小的能量谱图|最后,对不同频段的能量谱图采用不同的处理方法后,将各能量谱图相加处理后形成区域标识图像,最终得到原图像的目标和目标阴影分割图像.本文利用该方法对MSTAR切片图像进行了分割试验,并对分割图像与频谱最大值距离或方位分割算法和基于双参量CFAR与隐马尔科夫联合分割算法进行了分割图像对比度对比.实验结果表明,采用本文算法的合成孔径雷达分割图像,对比度明显提高,且保留了目标图像细节.     

Identification of novel oxadiazole-based benzothiazole derivatives as potent inhibitors of α-glucosidase and urease: Synthesis,in vitro bio-evaluation and their in silico molecular docking study

This research work represents a synthetic approach for the development of hybrids derivatives of oxadiazole-based benzothiazole (1–17) and diversity in derivatives was achieved using variety of aryl ring of S-substituted benzothiazole to see the effect on the biological activities. All the synthesized derivatives were evaluated for their in vitro α-glucosidase and urease inhibitory potential. The α-glucosidase and urease inhibition profile of the new derivatives represents moderate to good inhibitory potential with IC₅₀ values ranging from 4.60 ± 1.20 µM to 48.40 ± 7.70 µM (α-glucosidase) and 8.90 ± 2.80 to 57.30 ± 7.70 µM (urease) respectively. The results were compared to standard acarbose (38.60 ± 4.50 µM) and thiourea (58.70 ± 6.80 µM) drugs respectively. Among the synthesized series, the analogs 1 having IC₅₀ values of and 4.60 ± 1.20 (α-glucosidase), 8.90 ± 2.80 (urease) and 2 with IC₅₀ values of 5.60 ± 1.60 (α-glucosidase) and 10.90 ± 2.10(urease) were found to be significantly active against targeted α-glucosidase and urease enzymes. The structure of all the newly synthetics scaffolds were confirmed by using different types of spectroscopic techniques such as HREI-MS, ¹H- and ¹³C- NMR spectroscopy. The molecular docking studies of the synthesized derivatives showed good correlations with the experimental findings. The binding modes of active compounds and their interactions with active site residues revealed them as possible anti-diabetics and anti-urease leads. The degree of activity and docking studies displayed by the novel innovative structural hybrids of oxadiazole-based benzothiazole moieties make these compounds new active leads and promising candidates for the development of anti-diabetics and anti-urease agents.     

A novel technique for imaging with inhomogeneous fields

We introduce a simple, efficient, low-SAR method for magnetic resonance imaging in the presence of a static field with a permanent, and possibly large gradient. The technique, which is called slant-slice imaging is essentially a spin-echo imaging sequence except that the imaging slice is oriented such that the static field gradient can be used in conjunction with applied gradients during readout. Data are collected for 2D slices. Unlike single point imaging techniques, entire lines of k-space are acquired with each readout. The slant-slice pulse sequence is used to obtain high quality images, using a clinical scanner to simulate a static field with a large permanent gradient. The effects of the inhomogeneity are quantified by two parameters nu and q, which are useful for assessing the utility of a magnet design for 3D-MR imaging.     

基于小波的多极化机载合成孔径雷达海面风向反演

为了实现从合成孔径雷达(SAR)图像本身提取高精度的海面风向信息, 提高SAR海面风场反演精度,研究了多极化机载SAR海面风向反演技术, 借助小波分析相对傅里叶分析和局部梯度更精细的时-频分析能力, 将二维连续小波变换与快速傅里叶变换(FFT)相结合,提出一种新的机载SAR海面风向反演方法. 为验证反演方法的有效性,通过海上同步飞行试验获取多极化机载SAR数据及同步调查船实测风向数据,用于反演试验的数据比对.采用本文提出的方法, 利用多种小波基对机载C波段SAR的同极化和交叉极化数据进行风向反演, 将反演结果与美国国家环境预报中心再分析资料以及调查船实测风向进行比对. 结果表明,本文提出的基于小波分析的海面风向反演方法适用于机载SAR探测数据, 反演精度优于二维FFT法和局部梯度方法;小波基的选择对反演结果影响较大, Mexican-Hat小波基是机载SAR海面风向反演的最优小波基, 且同极化与交叉极化机载SAR数据均可用于海面风向的反演.     

四甲基吡嗪衍生物合成及其5-HT3受体拮抗活性的筛选

恶性肿瘤常用的内科治疗方法为放射治疗和化学治疗,这两种治疗方法均会造成严重的恶心和呕吐等胃肠道副反应．早期的抗呕吐药物不仅其止吐效果差,还伴有严重的锥体外系副反应．自从20世纪70年代末发现5-HT3受体与呕吐机制有关以来引,5-HT3受体及其拮抗剂的研究极为活跃,目前上市的药物有Ondansetron,Granisetron,Tropisetron和Azasertron等,还有许多药物正处于临床研究阶段。     

基于非线性预处理的SAR图像浮点数据压缩

提出了一种基于非线性预处理和DCT的SAR图像浮点数据压缩方法,通过对预处理前后DCT系数的熵和恢复图像信噪比的分析,确定符合SAR数据特征的预处理方法,再应用区域编码对其进行定值压缩。实验表明该方法可取得非常明显的效果。     

Novel benzoxazole-based thiosemicarbazide derivatives as new inhibitors of urease and β-Glucuronidase: Synthesis,in vivo anti-nematodal activity and ADMET prediction along with in silico study

Here, we discuss the synthesis of thiosemicarbazide derivatives based on benzoxazole. These compounds were obtained via sequence of reactions. The targeted products were confirmed using a number of spectroscopic methods, including NMR (1H and 13C) and EI-MS. After spectral confirmation all the synthesized compounds were evaluated for urease and β-Glucuronidase inhibitory activity in order to explore their biological significances in the presence of standard drug thiourea (IC₅₀ = 21.86 ± 0.40) and D-saccharic acid 1,4-lactone (IC50 value 22.00 ± 1.10 µM) respectively. Among the evaluated series, compounds 14 and 15 (1.10 and 0.01 and 2.20 and 0.60) were shown to have slightly greater potential than standard drugs. Anti-nematodal activity was also employed to explore the cytotoxic nature of synthesized analogs. In order to establish the binding relationship with enzyme active sites, molecular docking experiments were done and directions for compound modification based on SAR features were addressed. In addition, ADMET prediction study also investigated to found drug like properties of the potential analogs.