DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery

We present a facile approach to make aptamer‐conjugated FRET (fluorescent resonance energy transfer) nanoflowers (NFs) through rolling circle replication for multiplexed cellular imaging and traceable targeted drug delivery. The NFs can exhibit multi‐fluorescence emissions by a single‐wavelength excitation as a result of the DNA matrix covalently incorporated with three dye molecules able to perform FRET. Compared with the conventional DNA nanostructure assembly, NF assembly is independent of template sequences, avoiding the otherwise complicated design of DNA building blocks assembled into nanostructures by base‐pairing. The NFs were uniform and exhibited high fluorescence intensity and excellent photostability. Combined with the ability of traceable targeted drug delivery, these colorful DNA NFs provide a novel system for applications in multiplex fluorescent cellular imaging, effective screening of drugs, and therapeutic protocol development.     

基于次梯度选取的非光滑优化强次可行方向法

本文结合次梯度选取技术及割平面法和强次可行方向法的思想,提出了一个求解目标函数非光滑约束优化问题的强次可行方向算法.通过设计一个新的寻找搜索方向子问题和构造新型线搜索,算法不仅能接受不可行的初始点,而且能保持迭代点的强次可行性,同时避免在可行域外目标函数值的不适度增加.算法具备全局收敛性,且初步的数值试验表明算法是稳定有效的.     

Weak temperature gradient effect on the stability of the circular Couette flow

We have investigated the influence of a weak radial temperature gradient in a wide gap and large aspect ratio Couette-Taylor system. The inner cylinder is rotating and can be heated or cooled, the outer cylinder is at rest and immersed in a large thermal bath. We found that a radial temperature gradient destabilizes the Couette flow leading to a pattern of traveling helicoidal vortices occurring only near the bottom of the system. The size of the pattern increases as the rotation frequency of the cylinder is increased. We have characterized the spatiotemporal properties of the pattern and we have shown that it behaves as a wall mode found in the simulation of the complex Ginzburg-Landau equation with homogeneous boundary conditions.     

Transitions in a genotype selection model driven by coloured noises

This paper investigates a genotype selection model subjected to both a multiplicative coloured noise and an additive coloured noise with different correlation time τ1 and τ2 by means of the numerical technique. By directly simulating the Langevin Equation, the following results are obtained. （1） The multiplicative coloured noise dominates, however, the effect of the additive coloured noise is not neglected in the practical gene selection process. The selection rate μ decides that the selection is propitious to gene A haploid or gene B haploid. （2） The additive coloured noise intensity and the correlation time τ2 play opposite roles. It is noted that α and τ2 can not separate the single peak, while can make the peak disappear and ~-2 can make the peak be sharp. （3） The multiplicative coloured noise intensity D and the correlation time τ1 can induce phase transition, at the same time they play opposite roles and the reentrance phenomenon appears. In this case, it is easy to select one type haploid from the group with increasing D and decreasing τ1.     

A periodically poled LiNbO3 optical parametric generator in wavelength conversion from 2 to 3.88-4.34 μm

A periodically poled lithium niobate (PPLN) optical parametric generator (OPG) pumped by a laser diode (LD)-pumped Q-switched Tm,Ho:GdVO4 laser operated at 2.048 μm with pump pulse of 25 ns and repetition rate of 10 kHz is reported.     

A Strong Limit Theorem on Random Selection

In this paper, the idea of random selection in the theorem on gambling system is extended to Markov chains, by using the notion likelihood ratio and an analytic technique. A strong limit theorem on the relative frequency of ordered couple under random selection is established.AMS Subject Classification (2001) primary 60F15 Secondary 60J10     

LD-end-pumped Nd:YAP laser operating at 1341.4 nm and doubling of its frequency

We report an LD-end-pumped linearly-polarized continuous-wave (CW) Nd:YAP laser operating at 1341.4 nm. Making use of the plane-concave resonator (T = 2.4%) and the plane-plane resonator (T = 2.6%), we obtain linearly-polarized laser radiation at 1341.4 nm with a power of 3.15 and 2.86 W and corresponding optical slope efficiency of 18.4 and 17.5%, respectively. The effect of the laser oscillation mode on the output is analyzed. An experiment on the intra-cavity frequency doubling with an LBO crystal has been performed, and a laser power of 431 mW in one direction at 670.7 nm was obtained.     

InGaAsSb/AlGaAsSb长波长多量子阱激光器有源区的优化设计

系统地研究了波长为2.7μm的InGaAsSb/AlGaAsSb多量子阱激光器中有源区的优化设计.分别用含应变势的6带KP模型和抛物带模型计算价带和导带的能带结构，并得到薛定谔方程和泊松方程的自洽解，由此计算量子阱在载流子注入时的增益谱.研究表明制约量子阱增益的主要因素不是跃迁矩阵元，而是粒子数反转程度，尤其是空穴填充HH1子带的概率.增加压应变或减小阱宽都会提高量子阱增益.前者降低了价带HH1子带空穴的平面内有效质量；后者拉大了价带子带间距，尽管它同时略微增加了空穴有效质量.这两种因素都导致价带顶空穴态