水溶性导电聚苯胺的制备*

水溶性聚苯胺在防腐涂料、电磁屏蔽、生物医学等领域有重要应用前景。该文结合本研究组在水溶性聚苯胺自支撑膜方面的研究进展,总结了水溶性聚苯胺的制备方法,并重点综述了用嵌段和接枝等共聚法制备的水溶性聚苯胺及其共聚机理,提出水溶性导电聚苯胺今后的研究方向。     

水-有机两相体系中钌络合物催化肉桂醛选择性加氢瓜研究

对RuCl3·XH2O和TPPTS[P(m-C6H4SO3Na)3]原位合成的水溶性钌膦络合物在水-有机两相体系中对肉桂醛的选择性加氢反应,考察了反应温度时间、膦配体浓度、搅拌速度、底物和催化剂之比等条件对反应活性和选择性的影响.对比了单长工链阳离子表面活性剂CTAB和双长链阳离子表面活性剂DCMAB(dicetyldimethylammonium)的助催化作用,发现DCMAB化作用明显优于CTAB,在DCMAB助催化作用下,转化率98.3%,选择性96.9%.     

染料木素磺酸钠制备及其抗脂质过氧化作用

染料木素磺酸钠制备及其抗脂质过氧化作用;染料木素;染料木素磺酸钠;水溶性;抗脂质体过氧化     

1-(4-氨基苯基)-2-(1-哌啶基)-1-丙酮盐酸盐的合成及其光引发性能

1-(4-氨基苯基)-2-(1-哌啶基)-1-丙酮盐酸盐的合成及其光引发性能;氨基苯乙酮;水溶性;光引发剂     

Solid Dispersions of Ketoprofen in Drug-Loaded Electrospun Nanofibers

Solid dispersions of ketoprofen in nanofibers were prepared using electrospinning process with polyvinylpyrrolidone as the filament-forming polymer. Results from differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, and fourier-transform infrared suggested that ketoprofen was well distributed in the polymer nanofibers in an amorphous solid dispersion state due to the hydrogen bonding between them. In vitro wetting and dissolution tests showed that the nanofibers could absorb water from the wet papers and wetted within several seconds, and ketoprofen could be exhausted within 30 seconds. Electrospinning is a useful process for the preparation of solid dispersions.     

Dextran-coated CdSe quantum dots for the optical detection of monosaccharides by resonance light-scattering technique

A resonance light-scattering (RLS) detection method for saccharides was developed using dextran-coated CdSe quantum dots (dextran-CdSe-QDs) optical probes. The dextran-CdSe-QDs can be aggregated with concanavalin A (Con A), and the change in RLS intensity is used to monitor the extent of aggregation. The presence of glucose competitively binds with Con A, dissociating the Con A/dextran-CdSe-QDs complexes, affording the RLS intensity change and hence determining glucose concentrations in the range from a few to about 90 mM. Transmission electron microscopy was used to investigate the competitive interaction between glucose and dextran-CdSe-QDs with Con A. The competitive strategy could also be used to detect similar types of saccharides and the affinities of various monosaccharides for Con A increased in the order galactose?glucose < fructose < mannose. The proposed method was successfully applied to determine glucose in the human serum.

A resonance light-scattering (RLS) detection method for saccharides was developed using dextran-coated CdSe quantum dots (dextran-CdSe-QDs) optical probes. The dextran-CdSe-QDs were coupled to concanavalin A (Con A) to facilitate the aggregation of nanoparticles. The presence of glucose competitively binds with Con A, dissociating the Con A/dextran-CdSe-QDs complexes affording the RLS intensity change and hence determining glucose in the range from a few millimolar to about 90 mM. The proposed method was applied to the determination of glucose in human serum samples with satisfactory results.

     

A Novel Thermothickening Aqueous System Prepared from Hydrophobically-Modified Acrylamide Copolymer,Poly(N-isopropylacryl-amide) and Sodium Dodecyl Benzene Sulfonate and Its Mechanism Studies

A new thermothickening aqueous system was presented based on mixtures of hydrophobically-modified acrylamide copolymer (HMPAM), poly(N-isopropylacryl-amide) (PNIPAM) and sodium dodecyl benzene sulfonate (SDBS). Unique in the thermothickening system, a maximum viscosity and the temperature (T _max) when reaching such viscocity change independently, reflects the presence of intermolecular interactions. The T _max of the new system suggests that its thermothickening behavior is correlated to the cloud point temperature (T _c) of PNIPAM, which can be easily adjusted to desired values by the addition of SDBS. The experimental data also indicate that the temperature between the rheological transition temperature (T _t) and T _max in HMPAM+PNIPAM+SDBS is within the range of 35–65°C, and the thermothickening behavior originates from the reinforcement of the association network between HMPAM, PNIPAM and SDBS. Consequently, the viscosity over the corresponding thermosensitive range upon cooling is higher than that upon heating.     

Evaluation of carbonic anhydrase and paraoxonase inhibition activities and molecular docking studies of highly water-soluble sulfonated phthalocyanines

The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes ( 1 and 2 ) are reported for the first time. The binding of p-sulfonylphenoxy moieties to the phthalocyanine structure favors excellent solubilities in water, as well as providing an inhibition effect on carbonic anhydrase (CA) I and II isoenzymes and paraoxonase (PON1) enzyme. According to biological activity results, both complexes inhibited hCA I, hCA II, and PON1. Whereas 1 and 2 showed moderate hCA I and hCA II (off-target cytosolic isoforms) inhibitory activity (Ki values of 26.09 µM and 43.11 µM for hCA I and 30.95 µM and 33.19 µM for hCA II, respectively), they exhibited strong PON1 (associated with high-density lipoprotein [HDL]) inhibitory activity (Ki values of 0.37 µM and 0.27 µM, respectively). The inhibition kinetics were analyzed by Lineweaver–Burk double reciprocal plots. It revealed that 1 and 2 were noncompetitive inhibitors against PON1, hCA I, and hCA II. These complexes can be more advantageous than other synthetic CA and PON inhibitors due to their water solubility. Docking studies were carried out to examine the interactions between hCA I, hCA II, and PON1 inhibitors and metal complexes at a molecular level and to predict binding energies.     

水溶性C60衍生物的合成及其生物活性

综述近年在水溶性Ｃ_（６０）衍生物合成及生物活性方面所取得的进展。     

一类新的多分枝大分子

本文介绍了一类新的瀑布状的多分枝大分子(cascade)。这种合成方法可以很精确地控制大分子的形状和分子量。最后展望了这类大分子在生态学、工业与医学方面可能的应用。