Synthesis of bromine-and iodine-containing perhaloisothiazoles

A method was developed for the synthesis of bromine- and iodine-containing perhaloisothiazoles by bromination and iodination of 3-bromoisothiazole prepared from the available 3-hydroxyisothiazole. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1887–1888, October, 1997.     

TEBABr_3对苯胺类的溴代反应

作者在三乙基苄基氯化铵和溴酸钠的水溶液中加入氢溴酸,以高产率制得 PhCH_2Et_3N~+·Br_3~-(TEBABr_3,1)。1为橙色固体,m.p.73～74℃,能在 CH_3OH-CH_2Cl_2介质中于 NaH-     

五氟溴苯的合成工艺研究

五氟溴苯是一种非常重要的化工中间体.五氟苯甲酸通过脱羧、溴化两步反应可以得到五氟溴苯.本文通过采用加压脱羧的方法制备五氟苯,反应时间短,产品产率和纯度高,且操作简单方便,工艺绿色环保,适合工业化.同时分别研究了脱羧和溴化反应中反应条件对目的产物收率的影响.     

Preparation of highly hindered polyenes with tert-butyl groups in internal positions

The conjugated tetraenes 3 and 4 a – c have been prepared and shown to possess an orthogonal structure. This was not only demonstrated by their spectroscopic properties and X‐ray structural analysis of solid representatives (e.g., 4 a – c ) but also by the resolution of these chiral compounds by GC and HPLC chromatography using various chiral selector systems. The chemical behavior of the typical tetraene 4 a has been studied using bromination, hydrogenation, epoxidation, and photo equilibration reactions.     

Über eine Reaktion von o-Hydroxybenzylalkoholen mit Estern von Säuren des Phosphors mit der Koordinationszahl 3

Abstract

o-Hydroxybenzyl alcohol reacts with trimethyl phosphite under smooth conditions to o-hydroxyphenylmethane phosphonic acid dimethyl ester. This unusual reaction is of widest applicability. Derivatives of o-hydroxybenzyl alcohol independent of type, number or position of substituents in the ring, react with alkyl esters of phosphorous, phosphonous or phosphinous acids in an analogous process, forming the corresponding o-hydroxyphenylmethane phosphonic or phosphinic esters or phosphine oxides.     

Oxidative Nuclear Bromination of Substituted 4-Pyridones Using Pyridinium Bromochromate

An alternative convenient approach for the bromination of various poly-substituted 4-pyridones has been developed via an oxidative nuclear bromination in the presence of sole pyridinium bromochromate (PBC). The PBC performs the dual role of oxidant and source of Br⁺ during the process.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]