铁轴草中Teucvidin的衍生物研究

从唇形科植物铁轴草中分离得去甲克罗烷二萜化合物Ｔｅｕｃｖｉｄｉｎ，通过催化氢化、酯交换、水解等反应合成了８个衍生物，用＾１ＨＮＭＲ、ＭＳ和ＩＲ确定了其结构，初步生物活性测定结果表明，化合物Ⅱ和Ⅳａ的拒食作用显著。     

球笼烯（C_（60）／C_（70）载体钕系催化丁二烯聚合的研究

球笼烯（Ｃ_（６０）／Ｃ_（７０）载体钕系催化丁二烯聚合的研究赵春英，陈滇宝，仲崇祺，董文寰，徐玲，唐学明（青岛化工学院高分子材料系青岛２６６０４２）杨海滨，李明辉，邹广田（吉林大学超硬材料国家重点实验室长春１３００２３）关键词球碳载体钕系催化剂，聚丁...     

Aqueous Solubilities, Infinite Dilution Activity Coefficients and Octanol–Water Partition Coefficients of Tricyclic Analogs of Acyclovir

Solubilities of tricyclic analogs of acyclovir have been determined in water at 25, 35, and 45°C and in octanol, water-saturated octanol, and octanol-saturated water at 25°C. Octanol-water partition coefficients were determined at 25°C. Melting temperatures and molar enthalpies of fusion were measured. Activity coefficients in water, octanol, and in aqueous octanol solutions were determined and are discussed. The effect of hydrophilic and hydrophobic substituents in the tricyclic analogs on their thermodynamic properties are discussed. The standard Gibbs energy of transfer between the saturated phases were found to correlate with known values of the melting point of the solvents and the solubilities of the solute. For a number of the compounds examined, correlations between the minimum inhibitory concentration against the herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella-zoster virus (VZV), thymidine kinase-deficient (TK^–) strains of VZV and were established. Detailed conclusions have been derived concerning the relationships between the structure and the thermodynamic parameters of the compounds examined.     

Synthesis of 21-nor-22-oxa-1α,25-dihydroxyvitamin D3 derivatives in quest of a drug with low calcemic activity

Two 21-nor-22-oxa-1α,25-dihydroxyvitamin D₃ derivatives have been synthesized in quest of a drug with lower calcemic activity than Maxacalcitol, 22-oxa-1α,25-dihydroxyvitamin D₃, being used as antihyperparathyroidism and antipsoriatic drug. Of two 21-nor products obtained, the product carrying one carbon elongated side chain with diethylcarbinol moiety has been found to exhibit comparable differentiation-inducing activity to Maxacalcitol with much lower exhibition of calcemic activity.     

Synthesis of an enzyme-like imprinted polymer with the substrate as the template, and its catalytic properties under aqueous conditions

Transition state analogues (TSAs) have long been regarded as ideal templates for the preparation of catalytically active synthetic imprinted polymers. In the current work, however, a new type of molecularly imprinted polymer (MIP) was synthesized with the substrate (homovanillic acid, HVA) as the template and hemin introduced as the catalytic center, with the use of plural functional monomers to prepare the active sites. The MIP successfully mimicked natural peroxidase, suggesting that it may not be imperative to employ a TSA as the template when preparing enzyme-like imprinted polymers and that the imprinted polymer matrix provided an advantageous microenvironment around the catalytic center (hemin), essentially similar to that supplied by apo-proteins in natural enzymes. Significantly, by taking advantage of the special structure of hemin and multiple-site interactions provided by several functional monomers, the intrinsic difficulties for MIPs in recognizing template molecules in polar solutions were overcome. The newly developed polymer showed considerable recognizing ability toward HVA, catalytic activity, substrate specificity and also stability, which are the merits lacked by the natural peroxidase. Meanwhile, the ease of recovery and reuse the MIP implies the potential for industrial application.     

1─芳氧基乙酰基─4─苯甲酰氨基硫脲衍生物的合成及其生物活性研究

１─芳氧基乙酰基─４─苯甲酰氨基硫脲衍生物的合成及其生物活性研究魏太保，陈继畴（西北师范大学化学系，兰州，７３００７０）杨素铀，王秀春（西北师范大学生物系，兰州，７３００７０）关键词：１—芳氧基乙酰基—４—苯甲酰基氨基硫脲，相转移催化，合成，生物活性...     

The ionization of perchloric and hydrofluoric acids in aqueous solution

Cyclical bifurcated hydrogen bonded structures are proposed for aqueous solutions of hydrofluoric acid and for the bifluoride ion which are consistent with the spectral data. The structure proposed for HF is also applicable to solutions in organic solvents. Raman spectra of tetramethylguanidinium perchlorate suggest that the corresponding Raman spectra of perchloric acid solutions may not be interpreted in terms of a completely dissociated acid. Other evidence including activity coefficient, heat capacity and partial molal volume data suggest that there is some association in relatively dilute perchloric acid solutions between the perchlorate ion and the hydrated proton. This association decreases in concentrated aqueous solutions.     

2-羟丙基三甲基氯化铵壳聚糖的制备及其性能研究

以脱乙酰度为95.37%的壳聚糖(CTS)为原料,异丙醇为溶剂,2,3-环氧丙基三甲基氯化铵为改性剂,于80℃反应12 h合成了水溶性季铵盐2-羟丙基三甲基氯化铵壳聚糖(HACC)。HACC的吸水保水性是CTS的2倍～3倍,加入化妆品中培养2周后菌落总数少于100 CFU.g-1。     

Synthesis and biological activity of certain amino-derivatives of 5α-steroids

Certain 17β-aminoderivatives of 5α-steroids based on tigogenin were synthesized and their antitumor activity was studied. The structures of the synthesized compounds were confirmed by NMR and IR spectroscopy and mass spectrometry. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 263–265, May–June, 2006.     

γ－芳基取代烯丙醇菊酯的合成及杀虫活性

γ－芳基取代烯丙醇菊酯的合成及杀虫活性陈亚娟，黄润秋，马军安（南开大学元素有机化学研究所，天津，３０００７１）关键词γ－芳基取代烯丙醇，拟除虫菊酯，杀虫活性第一个人工合成除虫菊酯烯丙菊酯保留了天然除虫菊酯醇部分的环戊烯醇酮结构，至今仍广泛用作卫生杀虫...