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Summary The chiral discrimination of phenoxypropionic acid herbicides by reversed-phase chromatography on a teicoplanin phase has been re-examined using the perturbation method to calculate the solute distribution isotherms. The effects of both temperature and the methanol (organic modifier) content of the mobile phase on the chiral discrimination mechanism were well described by the bi-Langmuir model. The method confirmed a change in the mechanism of enantiomer retention at a critical temperature, T*, and showed that the mechanism was independent of (i) herbicide molecular structure, i.e. the position of the chloro group on the phenol ring, and (ii) the absolute configuration of the carbon atom. Enantioselectivity was enhanced by increasing the mobile phase methanol content. Use of this approach also revealed that secondary sites on the teicoplanin surface were involved in the processes determining both retention and selectivity. It was clearly demonstrated that these secondary sites of low affinity were not affected by the temperature change and were not involved in the chiral recognition mechanism. 相似文献
23.
苯并三氮唑及其羧酸酯衍生物对铜缓蚀机理的分子动力学模拟研究 总被引:1,自引:0,他引:1
用分子动力学(MD)方法, 模拟计算了5种铜缓蚀剂[苯并三氮唑(BTA)、苯并三氮唑-5-羧酸甲酯(MBTC)、苯并三氮唑-5-羧酸丁酯(BBTC)、苯并三氮唑-5-羧酸己酯(HBTC)、苯并三氮唑-5-羧酸辛酯(OBTC)]与Cu2O晶体的相互作用. 结果发现, 中性条件下缓蚀剂分子与Cu2O晶体的结合能均大于酸性条件下的数值, 但两种条件下结合能的大小排序均为OBTC>HBTC>BBTC>MBTC>BTA. 对体系各种相互作用以及对关联函数g(r)的分析表明, 体系结合能主要由库仑作用提供, Cu2O晶体中的Cu原子与缓蚀剂分子中的N原子之间形成了配位键. 在与Cu2O(001)晶面结合过程中, BTA及其衍生物分子发生了扭曲变形, 但形变能远小于体系的非键相互作用能. 相似文献
24.
A new pentacyclic triterpenoid, urs-12-en-29α-oic acid-3β-ol (1), was obtained from the ethanol extract of Chinese herb Oldenlandia cantonensis How. The structure was elucidated by spectroscopy methods, including nuclear magnetic resonance (NMR) (1D and 2D), infrared
spectroscopy (IR), and mass spectrometry (MS). 1 exhibited significant inhibitory activity against the human DNA topoisomerase
I (hTopo I), the cancer cell lines BEL-7402 and MCG-803, with the IC50 values 12.0, 6.5, and 8.0 μg/mL, respectively. The volatile oil, the fraction of petroleum ether: EtOAc = 20:1 (V/V) on Si gel chromatography, was also quantitatively analyzed by gas chromatography mass spectrometry (GC-MS). As a result,
60 compounds were identified. Among them, the long chain aliphatics, terpenes and steroids, as the representative structure
type, were found with percentages of 36.16%, 6.42% and 9.28%, respectively.
Translated from Chinese Journal of Applied Chemistry, 2006, 23(8): 871–874 [译自: 应用化学] 相似文献
25.
环氧合酶-2抑制剂的三维定量构效关系研究 总被引:2,自引:0,他引:2
建立三环系COX-1和COX-2抑制剂结构与活性的三维定量构效关系模型,为设 计新型的具有选择性的COX-2抑制剂提供线索。通过与酶的对接并优化,确定化合 物在受体结合腔中的构象,利用比较分子力场分析方法建立三维定量构效关系模型 。模型1R_(cv)~2=0.685,最佳主成分数为6,传统相关系数为R~2=0.988, F-726. 2,标准偏差S = 0.080;模型2 R_(cv)~2 = 0.573,最佳主成分数为6,传统相关 系数为R~2=0.996, F = 1147.6,标准偏差S = 0.034。所得的模型不仅解释了化合 物的构效关系,而且对预测集中的化合物有很好的预测能力;比较不同模型的系数 相关图,分析了结构与活性、结构与选择性的关系,得到的结果可以指导新化合物 的设计与合成。 相似文献
26.
Emmanuel Burgos 《Tetrahedron letters》2004,45(17):3465-3469
4-deoxy-4-Phosphonomethyl-d-erythronate, an isosteric and hydrolytically stable analogue of the known ribose-5-phosphate isomerase inhibitor 4-deoxy-4-phospho-d-erythronate, was obtained by a 14-step synthesis from d-arabinose through an highly improved synthesis of the precursor 5-deoxy-5-phosphonomethyl-d-arabinose. The title compound appears as the first stable and potent competitive inhibitor of the enzyme catalyzed isomerization of ribose-5-phosphate to d-ribulose-5-phosphate (Ki=74 μM, Km/Ki=100), exhibiting only a 3-fold weaker inhibitory activity than its phosphate analogue. 相似文献
27.
建立了气相 质谱联用 (GC/MS)测定苯乙烯中阻聚剂对叔丁基邻苯二酚含量的方法。苯乙烯样品直接进样 ,通过毛细管柱 (HP 1,30m× 0 32mmi.d .× 0 2 5 μm)分离 ,由电子轰击 (EI)源于选择离子监测 (SIM)模式下进行检测。结果表明 ,对叔丁基邻苯二酚含量在 5mg/kg~ 5 0mg/kg时线性关系良好 (r2 =0 9987) ,回收率高 ;与美国材料测试标准ASTMD4 5 90中的分光光度测量法比较具有操作简捷、准确度高的特点。 相似文献
28.
Rie Namme 《Tetrahedron letters》2005,46(17):3033-3036
Acid-promoted α-stereoselective O-glycosidation of 1-exo-methylenesugars was successfully applied to the synthesis of a PI-88 analogue. By using methanesulfonic acid as a promoter, 1′-C-methyl-α-disaccharides with p-methoxybenzyl protection were obtained in high yield. The sequence of selective deprotection and glycosidation provided 1-C-methyl-pentasaccharide efficiently. 相似文献
29.
Yu. I. Kuznetsov 《Russian Journal of Electrochemistry》2004,40(12):1287-1291
Studies on the iron passivation by organic acid anions in aqueous solutions are briefly reviewed. It is shown that the passivation can be caused only by their adsorption, retarding both the iron dissolution and the formation of oxide films. Earlier, it had been believed that oxide films play a dominant role in the iron passivation in neutral solutions. The recent viewpoint is that such nonoxide iron passivation can occur in solutions of salts of not only aromatic amino acids (sodium phenylantranilate and its substitutes), but other carboxylic acids as well. An important role of chemisorption and hydrophobic properties of anions for the formation of adsorption passive films is emphasized. New possibilities for inhibitor protection of iron against corrosion, which is based on adsorptive passivation, are pointed out.Translated from Elektrokhimiya, Vol. 40, No. 12, 2004, pp. 1503–1507.Original Russian Text Copyright © 2004 by Kuznetsov. 相似文献
30.
Prostaglandin D2 synthase (PGDS) (beta-trace protein) is a highly abundant cerebrospinal fluid (CSF) glycoprotein. A number of studies have been performed to determine the potential value of this protein for the diagnosis of various neurological disorders. The measurement of total PGDS levels in CSF has proved marginally useful for this purpose, but promising results were obtained while investigating changes in the posttranslational modifications (PTM) pattern. Using 2-DE analysis, we previously showed that PGDS is differentially expressed in ante- and post mortem CSF samples. In the present study, we examined whether the PGDS isoforms may help to distinguish stroke and neurodegenerative disease patients from healthy subjects. The pattern of PGDS PTM was analyzed in CSF from patients with various neurological disorders (n = 44) using IEF/immunoblotting techniques. Strong alterations of this pattern were detected in patients with different forms of degenerative dementia. These findings are consistent with PGDS being altered in some neurological diseases and provide new opportunities for clinical applications. 相似文献