Two New Dammarane‐Type Bisdesmosides from the Fruit Pedicels of Panax notoginseng

Two new dammarane‐type triterpenoidal saponins, notoginsenosides FP₁ ( 1 ) and FP₂ ( 2 ), were isolated from the fruit pedicels of Panax notoginseng, along with 22 known compounds. Their structures were elucidated on the basis of spectroscopic evidences and chemical methods. The known compounds were identified as ginsenosides Rg₁ ( 3 ), Re ( 4 ), Rb₃ ( 5 ), Rc ( 6 ), Rd ( 7 ), Rb₂ ( 8 ), Rb₁ ( 9 ), F₂ ( 10 ), and F₁ ( 11 ); as notoginsenosides R₁ ( 12 ), Fa ( 13 ), and Fc ( 14 ); as vina‐ginsenoside R₇ ( 15 ); as gypenosides IX ( 16 ), XVII ( 17 ), and XIII ( 18 ), and as chikusetsusaponin‐L₅ ( 19 ), quercetin 3‐O‐β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐galactopyranoside ( 20 ), kaempferol 3‐O‐β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐galactopyranoside ( 21 ), benzyl‐β‐primeveroside ( 22 ), (S)‐tryptophan ( 23 ), and icariside B₆ ( 24 ). Compounds 15, 19 and 22 – 24 are reported for the first time from the title plant.     

Five New Nortriterpenoids from the Stems of Schisandra neglecta

Five new nortriterpenoids, schicagenins D–F ( 1 – 3 , resp.) and negleschidilactones A and B ( 4 and 5 , resp.), together with eleven known ones, were isolated from the stems of Schisandra neglecta. Their structures were established on the basis of extensive spectroscopic analyses. All the compounds were evaluated for their activities regarding insulin sensitivity in 3T3‐L1 differentiated adipocytes. None of them showed a significant bioactivity at 10 μM concentration.     

Stelliferins J-N, isomalabaricane-type triterpenoids from Okinawan marine sponge Rhabdastrella cf. globostellata

Five new isomalabaricane-type triterpenoids, stelliferins J-N (1-5), were isolated from Okinawan marine sponge Rhabdastrella cf. globostellata. The structures of 1-5 were elucidated from the spectroscopic data and chemical means including application of a modified Mosher’s method and an exciton chirality method.     

Isolation,vibrational analysis,quantum chemical studies,nature of bonding,and molecular docking studies of triterpenoid isolates from Ganoderma lucidum as potent typhoid fever agent

The bacteria Salmonella Typhi is the source of the dangerous and perhaps fatal disease known as typhoid fever. Typhoid fever treatment is difficult despite the availability of potent medications due to the rise of multi-drug resistance strains. Herein, the extraction, LC-MS and FT-IR spectral characterization, density functional theory (DFT) and molecular docking investigation of 3,15-dihydroxy-11-toxolanost-8,24-dien-26-oic acid (C₃₀H₄₅O₅) [MDC_1], Ganoderic acid F (C₃₂H₄₁O₉) [MDC_2], and Ganolucidic acid E (C₃₀H₄₃O₅) [MDC_3] isolated compounds from G. lucium against Salmonella Typhi enzyme, DNA gyrase B is presented along with the influence of solvation in polar and non-polar solvents. The FT-IR spectral results show that the triterpenoid extract of G. lucidum contains oxygen atoms, which mainly exist in functional groups (such as CO, O–H, C–O) and are consistent with the general molecular structures of triterpenoids. The reactivity parameters in the gas phase show that MDC_1 and MDC_3 have higher energy gaps whereas MD_2 has the lowest energy gap, indicating that it is more reactive than the other complexes. The energy gap of the compounds in solvent also shows a little shift, compared to the energy gap in Ethanol and Heptane, respectively. The results of the molecular docking study revealed several small molecules with strong binding affinities for the protein targets, suggesting that they could be used as potential therapeutics for typhoid fever. Therefore, this study suggests that molecular docking is a powerful tool for identifying novel therapeutics against tropical diseases such as typhoid fever.