Calixarenes for Biochemical Recognition and Separation

This review summarizes reference data on the molecular recognition of bioactive molecules by calixarenes. It emphasizes on selectivity, the design principles of the host molecules, and the type of interactions as basis for new analytical and separation methods. The following classes of compounds are discussed: amino acids, peptides and proteins, lectins, enzymes, nucleotides and nucleosides, saccharides, steroids and other guests. Also considered are induced chirality and calixarenes with substituents complementary to biomolecules. Enzyme mimics and amines are briefly discussed.     

光谱法研究水溶性杯[8]芳烃对伊红的分子识别作用

采用荧光光谱法和紫外-可见光谱法研究了水溶性对-二甲氨甲基-杯[8]芳烃(简称杯[8]胺)对伊红的分子识别作用。研究发现,对-二甲氨甲基-杯[8]芳烃与伊红存在较强的静电作用,两者之间形成了2:1型的络合物,络合常数为2.1×109Lmol-1,小牛胸腺DNA对杯[8]胺-伊红络合物的稳定性有较大影响,DNA能夺取杯[8]胺-伊红络合物中的杯[8]胺,导致伊红游离,预示着杯[8]胺是良好的药物载体分子。同时考察了β-环糊精、几种常见有机溶剂和溶液的pH值等对杯[8]胺与伊红相互作用的影响,初步探讨了两者相互作用的机理。