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61.
The carbon-carbon bond-forming method in aqueous media was investigated by using indium as a single-electron transfer radical initiator. The indium-mediated intermolecular alkyl radical addition to imine derivatives and electron-deficient CC bond proceeded effectively. 相似文献
62.
63.
Dr. Hannah A. Minas Romain M. M. François Dr. Franziska Hemmerling Dr. Amy E. Fraley Cora L. Dieterich Dr. Simon H. Rüdisser Dr. Roy A. Meoded Sabrina Collin Prof. Dr. Kira J. Weissman Dr. Arnaud Gruez Prof. Dr. Jörn Piel 《Angewandte Chemie (International ed. in English)》2023,62(34):e202304481
Modular trans-acyltransferase polyketide synthases (trans-AT PKSs) are enzymatic assembly lines that biosynthesize complex polyketide natural products. Relative to their better studied cis-AT counterparts, the trans-AT PKSs introduce remarkable chemical diversity into their polyketide products. A notable example is the lobatamide A PKS, which incorporates a methylated oxime. Here we demonstrate biochemically that this functionality is installed on-line by an unusual oxygenase-containing bimodule. Furthermore, analysis of the oxygenase crystal structure coupled with site-directed mutagenesis allows us to propose a model for catalysis, as well as identifying key protein-protein interactions that support this chemistry. Overall, our work adds oxime-forming machinery to the biomolecular toolbox available for trans-AT PKS engineering, opening the way to introducing such masked aldehyde functionalities into diverse polyketides. 相似文献
64.
《Comptes Rendus Chimie》2016,19(7):857-862
Flavonoids due to their various interesting biological properties such as antifungal activity were investigated in Mentha piperita leaves. The butanolic fraction obtained from the hydro-alcoholic crude extract of M. piperita is rich in flavonoids; it reduced in vitro the mycelium growth of Phoma sorghina and Fusarium moniliforme around 72% and 55%, respectively, when used at a concentration of 5 mg/ml. In addition, the chemical conversion of the flavonoids in the butanolic fraction into their oxime derivatives increased the antifungal activity since the percentage of inhibition increased to 84% and 65% against P. sorghina and F. moniliforme, respectively, at 5 mg/ml. Butanolic fraction and oxime inhibition effects on spore germination of the two fungi were also observed. These results suggest that, M. piperita flavonoids could be used as botanical fungicides to protect cereals against infection from P. sorghina and F. moniliforme. 相似文献
65.
Deprotection of oximes to the corresponding carbonyl compounds in silica sulfuric acid/surfactant/paraformaldehyde system can be carried out in excellent yields at 50 °C in water under ultrasound irradiation. 相似文献
66.
Arsalan Mirjafari Niloufar Mobarrez James H. Davis Jr Jalil Noei 《Comptes Rendus Chimie》2011,14(12):1065-1070
A wide variety of oximes were prepared from different types of alcohols with hydroxylamine hydrochloride using 1-methylimidaziloum nitrate, [Hmim][NO3], ionic liquid as a reaction medium and promoter under microwave irradiation. This protocol provides a one-pot oxime synthesis with high yields that is facile, eco-friendly and the ionic liquid can be recovered and reused. 相似文献
67.
68.
SENTHILKUMAR Annamalai THARINI Kumaravel SETHURAMAN Mathur Gopalakrishnan 《物理化学学报》2012,28(2):399-406
Three synthesized piperidin-4-one oximes,3-ethyl-2,6-diphenyl-piperidin-4-one oxime(A),1-methyl-3-isopropyl-2,6-diphenyl-piperidin-4-one oxime(B),and 3-isopropyl-2,6-diphenyl-piperidin-4-one oxime(C),were tested at different concentrations to determine their ability to inhibit corrosion of mild steel in 1 mol.L-1 H2SO4 and measured by a mass loss method(at various temperatures),polarization and impedance measurements,X-ray diffraction(XRD),scanning electron microscopy(SEM) with energy-dispersive X-ray spectroscopy(EDS),and a quantum chemical method.The synergistic influence of compounds A,B and C with iodides has also been evaluated.All three compounds show good inhibition efficiency in the following order:A>B>C.Compounds A,B and C were found to physically adsorb on the surface of mild steel while obeying the Temkin isotherm.Polarization measurements indicated that these compounds behave as a mixed mode inhibitor.XRD and SEM with EDS studies revealed the formation of a protective barrier on the mild steel surface by these oximes.The electron donating ability of the studied molecules was tested using semi empirical methods.The studies revealed that the oxime nitrogen,the piperidine moiety,and the phenyl ring assist largely in corrosion control.The studies also showed that the steric crowding by the alkyl group in the piperidine ring affects the inhibitor efficiency.Further,it is interesting to note that all of the studied compounds exhibit synergism with iodide ions. 相似文献
69.
A convenient synthesis of 1-alkyl-2-chloro-1H-indole-3-carbaldehyde oximes(5a―5d) and 1-alkyl-2-phenoxy-1H-indole-3-carbaldehyde oximes(6a―6d) from 2-indolone was completed via the Vilsmeier-Haack reac-tion,with N-alkylation and oximation as the key steps.An improved one-pot method for the synthesis of 1-alkyl-2-alkoxy-1H-indole-3-carbaldehyde oximes(7a―7h) from 1-alkyl-2-chloro-1H-indole-3-carbaldehydes(3a―3d) was described.The Williamson reactions and esterification reactions were performed and the oxime-... 相似文献
70.
Katherine Nott Samuel Dufour Sylvie Heilporn Patrick Rollin Georges Lognay Michel Paquot 《Tetrahedron letters》2005,46(43):7377-7380
An efficient chemoselective ligation approach using an oxime bond was developed for the synthesis of amino acid derivatives of virginiamycin M1, a highly sensitive streptogramin antibiotic. 相似文献