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11.
Four new lupane triterpenoid saponins, along with one known lupane and eight hederagenin saponins, were isolated from the EtOH extract of the buds of Lonicera similis Hemsl. The structures of the new compounds were established as 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl 23-hydroxybetulinic acid 28-O-β-D-glucopyranosyl ester (lonisimilioside A, 1), 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl 23-hydroxybetulinic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (lonisimilioside B, 2), 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl betulinic acid 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (lonisimilioside C, 3) and 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl betulinic acid 28-O-β-D-glucopyranosyl ester (lonisimilioside D, 4), respectively. The cytotoxic activities of the isolates against human cancer cell lines HepG2, MCF-7 and A-549 were evaluated. Only the monodesmosidic saponin with a free carboxyl group at C-28 (12) exhibited significant cytotoxicities against HepG2, MCF-7 and A-549 cell lines with the IC50 values of 8.98 ± 0.19, 12.48 ± 0.45 and 11.62 ± 0.54 μM, respectively. Furthermore, Hoechst fluorescence 33342 staining was used to demonstrate that 12 could induce HepG2 and A-549 cells apoptosis significantly. 相似文献
12.
Two new triterpenoid saponins named lonimacranthoideⅣ(1) and lonimacranthoideⅤ(2) were isolated from the flower buds of Lonicera macranthoides Hand.-Mazz.(Caprifoliaceae).They have hederagenin as aglycone.LonimacranthoideⅣ(1) is a rare chlorogenic acid ester acylated on the C-23 of hederagenin.LonimacranthoideⅣis a new sulfated triterpenoid saponin.The structures of the saponins were established by chemical and spectral methods. 相似文献
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14.
V. I. Deineka V. N. Sorokopudov L. A. Deineka E. I. Shaposhnik S. V. Kol’tsov 《Chemistry of Natural Compounds》2005,41(2):162-164
The qualitative and quantitative compositions of anthocyans from fruit of plants of the Caprifoliaceae family grown under conditions of Belgorod region were investigated. The plants included elder species [Sambucus nigra L. (I), S. canadensis (II), and S. canadensis f. sceletoniana (III)], Viburnum opulus L., and Lonicera caerulea L. It has been found that the principal anthocyans of I are cyanidin-3-sambubioside (52.5%) and cyanidin-3-glucoside (37.1%) whereas from the other two elder species the principal component was cyanidin-3-sambubioside-5-glucoside, acylated p-coumaric acid, 70.9 (II) and 54.3% (III). Fruit of the other plants did not contain acylated anthocyans. The content of anthocyans in fresh or dried fruit was determined by spectrophotometry.__________Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 132–133, March–April, 2005. 相似文献
15.
黄褐毛忍冬中主皂苷成分的结构解析 总被引:1,自引:0,他引:1
报道了黄褐毛忍冬中的两个皂苷主成分, 其中化合物1为新化合物, 并对另一个含量最高的皂苷结构进行了修正. 相似文献
16.
Yu Chen Xu Feng Xiaodong Jia Ming Wang Jinyu Liang Yunfa Dong 《Chemistry of Natural Compounds》2008,44(1):39-43
The structures of seven triterpene glycosides (1–7), of which the 23-O-acetyl, 28-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl ester of hederagenin 3-O-β-D-glucopyranosyl-(1→3)-O-α-L-rhamnopyranosyl-(1→2)-O-α-L-arabinopyranoside (2) was new, from the flower buds of Lonicera macranthoides were established using chemical and NMR spectroscopic methods.
Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 32–34, January–February, 2008. 相似文献
17.
Kyo Bin Kang Dong Young Lee Mi Song Kim Tae Bum Kim Tae-Jin Yang 《Natural product research》2018,32(7):788-794
A new secoiridoid-derived guanidine alkaloid, argininosecologanin (1), along with 12 known iridoids and secoiridoids (2–13), was isolated from the roots of Lonicera insularis. The structures of the isolated compounds were established by the spectroscopic analysis and comparison of their spectral data with previously reported data. Compound 1 was assigned as the first secoiridoid-derived guanidine alkaloid isolated as a natural product. A plausible biogenetic pathway for 1 is suggested based on its structural similarity to (E)-aldosecologanin (4). 相似文献
18.
Zong‐Yun Li Hui‐Min Gao Jian Sun Liang‐Mian Chen Zhi‐Min Wang Qi‐Wei Zhang 《Helvetica chimica acta》2012,95(7):1144-1151
The new secoiridoid sulfonates 1 – 3 were isolated from the 50% EtOH/H2O extract of the sulfiting‐processed Lonicera japonica Flos (LJF) by semi‐prep. HPLC, and their structures were identified on the basis of mass spectrometry and NMR spectroscopy. HPLC and LC‐DAD‐MS/MS analyses of the different samples of LJF obtained by various process techniques suggested that the sulfur fumigation led to the decrease of secologanic acid ( 4 ) and the formation of secologanic acid‐derived sulfonate 1 and its derivatives 2, 2a , and 3 in the crude materials, which revealed that sulfur fumigation, the traditional process technique, could alter the phytochemical profiles of some Chinese herbal medicines. 相似文献
19.
Six novel cerebrosides, lonijaposides A1-A4, B1 and B2 (1-6) have been isolated from the flowers of Lonicera japonica. Their structures were established on the basis of 1D, 2D (DEPT, HMQC, HMBC and COSY) NMR, ESI-QTOF-MS/MS and chemical evidence. 相似文献
20.
Wei-Xia Song Yong-Chun Yang Jian-Gong Shi 《中国化学快报》2014,25(9):1215-1219
Two new β-hydroxy amino acid-coupled secoiridoids, named serinosecologanin (1) and threoninose- cologanin (2), were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their uncommon structures including absolute configurations were determined by spectroscopic data analysis, and confirmed by semisynthesis from the co-occurring secologanin (3) and secologanic acid (4). Compounds 1 and 2 exhibited resistant activity against β-glucosidase from almonds and hesperidinase from Aspergillus niger, they also showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor with inhibition rates of (34.9 ±3.1 )% and (53.6 ± 2.6)%, respectively. 相似文献