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21.
A facile and efficient synthesis of 1,5‐benzodiazepines with an arylsulfonamido substituent at C(3) is described. 1,5‐Benzodiazepine, derived from the condensation of benzene‐1,2‐diamine and diketene, reacts with an arylsulfonyl isocyanate via an enamine intermediate to produce the title compounds of potential synthetic and pharmacological interest in good yields (Scheme 1). In addition, reaction of benzene‐1,2‐diamine and diketene in the presence of benzoyl isothiocyanate leads to N‐[2‐(3‐benzoylthioureido)aryl]‐3‐oxobutanamide derivatives (Scheme 2). This reaction proceeds via an imine intermediate and ring opening of diazepine. The structures were corroborated spectroscopically (IR, 1H‐ and 13C‐NMR, and EI‐MS) and by elemental analyses. A plausible mechanism for this type of cyclization is proposed (Scheme 3). 相似文献
22.
Khadijah M. Al-Zaydi 《Journal of Saudi Chemical Society》2010,14(1):91-95
Coupling of 5-dimethylaminomethylene-3-methyl-2-(pyridine-2-ylimino)-thiazolidin-4-one (3) with diazotized methyl anthranilate afforded the 3-methyl-5-(2-methoxycarbonylphenylhydrazono)-2-pyridine-2-ylimino)thiazolidin-4-one (5). Reaction of 2-(arylamino)thiazol-4-ones 1a,b with arylidenemalononitriles under microwave irradiation gave 2-substituted amino-5-arylidenethiazolin-4-ones 9a–f. Alternatively, compound 9 could also be obtained by reacting compound 1 with aromatic aldehydes. Treatment of compound 9 with acetic acid yielded the corresponding thiazolin-2,4-diones 10. However, the reaction of 1 with cyanoacetic acid yielded the corresponding 4-cyanoacetyl derivative 12, in good yield. The 1H, 13C NMR spectra of some representative products and X-ray crystal structure determination are discussed. 相似文献
23.
Jan Světlík 《Monatshefte für Chemie / Chemical Monthly》1992,123(1-2):145-149
Summary An unpredecent formation of enamines in the reaction of 5-aryl-1-oxa-5-azaspiro[2.4]heptane-4,6-diones with morpholine and piperidine is reported. The transformations proceed via corresponding -aminoalcohols which were detected by13C-NMR.
Transformationen von biotechnisch verfügbarem Material, 2. Mitt.: Erstes Beispiel für die direkte Konversion von Spirooxiranen in Enamine
Zusammenfassung Es wird über die Bildung von Enaminen aus der Reaktion von 5-Aryl-1-oxa-5-azaspiro[2.4]heptan-4,6-dionen mit Morpholin oder Piperidin berichtet. Die Transformation verläuft über die entsprechenden -Aminoalkohole, die mittels13C-NMR nachgewiesen werden können.相似文献
24.
Krystyna Bogdanowicz-Szwed Małgorzata Krasodomska 《Monatshefte für Chemie / Chemical Monthly》2006,137(3):347-355
Summary. The tandem Michael addition and cyclization of 2-, 3-, and (4-pyridinylcarbonyl) thioacetanilides with arylidenemalononitriles yielded polysubstituted
pyridines and bipyridines. Tetrahydro-6-thioxopyridine-3-carbonitrile was dehydrogenated to its dihydro derivative by means
of HgO or DBU. The reaction of enamines of 3-, and (4-pyridinylcarbonyl)thioacetanilides with malononitrile furnished 3,4′- and 4,4′-bipyridines. 相似文献
25.
The Michael addition of ketone-derived enamines, metalated methylene active compounds and N-methyl pyrroles to γ-fluoro-α-nitroalkenes provided in moderate to good isolated yields the corresponding β-fluoroalkyl nitro compounds, which represent new interesting, highly functionalized building blocks in organofluorine chemistry. 相似文献
26.
The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described.The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides;and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields.Interestingly,the product 2b has shown a promising anticancer activity against HeLa cell lines(IC50=0.19 mmol/L). 相似文献
27.
Vladislav Yu. Korotaev Alexey Yu. Barkov Evgeniya G. Matochkina Mikhail I. Kodess Vyacheslav Ya. Sosnovskikh 《Tetrahedron》2014
3-Nitro-2-trichloro(trifluoro)methyl-2H-chromenes undergo a formal [4+2] cycloaddition reaction to cyclohexanone and pinacolone enamines, producing chromeno[3,4-c][1,2]benzoxazin-6-oxides with high diastereoselectivity and in good yields. In addition, some novel 2,3,4-trisubstituted chromanes were obtained. The stereochemistry of the products was established based on a 2D NOESY experiment and an X-ray diffraction study. 相似文献
28.
An efficient, simple synthesis of 2,3,4,9-tetrahydro-1H-xanthene-1-ones and 8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-ones is reported by one-pot condensation of 3-dimethylamino-2-cyclohexen-1-ones with hydroxybenzyl alcohols, phenol, and 2-naphthol Mannich bases or their quaternized derivatives. The mechanism of the reaction is believed to involve the formation of the o-quinone methide intermediate. 相似文献
29.
Pradeep Cheruku 《Tetrahedron letters》2008,49(51):7290-7293
The asymmetric hydrogenation of N,N-dialkyl and N-alkyl-N-aryl enamines to chiral tertiary amines was studied. All the N,P-ligated iridium complexes investigated were active catalysts for the reaction, but only those with bicycle-supported oxazoline-phosphine ligands gave reasonable stereoinduction. The best catalyst produced a range of chiral tertiary amines in up to 87% ee. 相似文献
30.
Vladislav Yu. KorotaevAlexey Yu. Barkov Pavel A. SlepukhinMikhail I. Kodess Vyacheslav Ya. Sosnovskikh 《Tetrahedron letters》2011,52(23):3029-3032
A new type of ring-chain tautomerism, which consists of the reversible conversion of bicyclo[4.2.0]octane derivatives into trisubstituted enamines was found and studied by 1H NMR spectroscopy. The starting materials were prepared by the stereoselective reaction of (E)-3,3,3-trichloro-1-nitropropene with cyclohexanone enamines. 相似文献