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11.
André Deratani Thierry Maraldo Estelle Renard 《Journal of inclusion phenomena and macrocyclic chemistry》1995,23(2):137-146
Reduction of-cyclodextrin (-CD) aromatic ketone (acetophenone and acetonaphthones) inclusion compounds were carried out in the presence of a large number of chemically inert species as potential co-guests. In several cases, it was observed that stoichiometric molar ratios of these compounds to ketone significantly modify the chiral induction yielding the inverted alcohol enantiomer and increasing the face selectivity. The results were found to depend strongly on the respective structure and shape of both the ketone and the additive, and on the molar ratio of-CD:ketone:third compound. These observations suggest the formation of a three-component inclusion complex in which the geometry of binding of the substrate and its mobility are changed with respect to the binary system. 相似文献
12.
轻度交联环糊精聚合物包结诱导自组装胶束的研究 总被引:1,自引:0,他引:1
合成了含β-环糊精的多取代单体(GMA)x-CD,经自由基聚合得到轻度交联的或高度支化的聚合物P(GMA)x-CD;同时由自由基共聚得到含有金刚烷侧基的疏水聚合物PtBA-ADA.研究表明,他们可在碱性水中通过β-CD和ADA间的包结络合作用形成胶束.当改变聚合物浓度比时,胶束尺寸在150~300 nm范围变化.TEM和AFM研究表明胶束具有核壳结构,核为疏水PtBA-ADA,壳为亲水(GMA)x-CD.通过对胶束壳CD基的化学交联,将胶束结构进一步固定化. 相似文献
13.
Erem Bilensoy Yasemin Çırpanlı Murat Şen A. Lale Doğan Sema Çalış 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):363-370
Human Papilloma Virus (HPV) infections are the major cause of cervical cancers. To achieve a better therapeutic efficacy and patient compliance in the treatment for HPV-induced cervical cancers, anticancer agent 5-fluorouracil has been formulated in a vaginal gel using the thermosensitive polymer Pluronic® F127 together with alternative mucoadhesive polymers e.g., hyaluronic acid, Carbopol 934 and hydroxypropylmethylcellulose. To increase its aqueous solubility and to achieve the complete release of 5-FU from the gel, the drug was incorporated as its inclusion complex with 1:1 molar ratio with either β-cyclodextrin or hydroxypropyl-β-cyclodextrin. Following the characterization of drug:CD complexes, thermosensitive gel formulations containing different mucoadhesive polymers and the drug in free or complexed form were characterized in vitro by determining the gelation temperature and the rheological behavior of different formulations along with the in vitro release profiles of these formulations in pH 5.5 citrate buffer. It was observed that complexation with cyclodextrin accelerated the release of 5-FU with the exception of formulation containing Carbopol 934 as mucoadhesive polymer. As far as rheological properties are concerned, favorable thermosensitive in situ gelling properties were obtained with formulations containing HPMC as mucoadhesive polymer. Complete release of 5-FU from gels were obtained with both complexes of β-CD and HP-β-CD and cytotoxicity studies against HeLa human cervical carcinoma cells demonstrated that 1% 5-FU:CD complexes were equally effective as 1% free 5-FU indicating better therapeutic efficacy with lower dose. 相似文献
14.
The binding constants of 1-alkanols with α-cyclodextrin (α-CD) were determined by indirect competitive potentiometry, although potentiometry is usually inapplicable to nonionic compounds. This novel method utilizes competitive binding of 1-alkanol and octyltrimethylammonium bromide (OTAB) to α-CD in aqueous media, where the concentration of free OTAB depending on the competitive binding is monitored with an OTAB-selective electrode. Therefore, the concentration of 1-alkanol is indirectly estimated from the observed electromotive force. The binding constants of 1-propapnol, 1-butanol, 1-hexanol, and 1-octanol with α-CD, obtained by this method, are close to the literature values. The implications and limitations of this indirect competitive potentiometry were discussed. 相似文献
15.
A method is proposed to prepare β-cyclodextrin (β-CD)/polyaniline (PANI) inclusion complex. In this route, benzoyl peroxide (BPO, the oxidant) is first encapsulated into the cavity of β-CD. Aniline is then carried into the cavity of β-CD by supercritical (SC) CO2, which polymerizes in situ to form inclusion complex. The product is characterized by FT-IR, UV-Vis, 1H NMR and XRD techniques. The results suggest that the columnar inclusion complexes may be formed. 相似文献
16.
L. Bardi C. Martini F. Opsi E. Bertolone S. Belviso G. Masoero M. Marzona F. Ajmone Marsan 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):439-444
In situ bioremediation of polycyclic aromatic hydrocarbons (PAH) polluted soils can be improved by the augmentation of degrading
microbial populations and by the increase of hydrocarbon bioavailability. β-cyclodextrin (β-CD) significantly accelerate the
induction of hydrocarbon biodegradation, but it is not still clear its effectiveness during final, slower stages of degradation.
Moreover, it is yet not known if the PAH uptake from plants is influenced by the presence of CD. A field study was carried
out by creating two plots (A and B). Diesel fuel was spread on the surface, and on plot B a commercial microbial consortium
and β-CD were spread. Soybean was seeded in both plots. Soil samples were withdrawn every 10 cm layers from 0 to 60 cm depth,
before fuel spreading, immediately after seeding and after soya harvesting. Chemical and microbial analyses were carried out
throughout the process to characterize the soil and to determine residual PAHs. Soybean seeds were analyzed for PAH content.
It was observed that β-CD induced a significant increase of PAH degradation rate. The microbial inoculum did not improve the
degradation; biodegradation activity was strong in superficial layers, and some PAH leaching was observed, that was reduced
by CD. The analysis of PAH in soyabeans revealed that an uptake of hydrocarbons occurred, and that it was more significant
in plot B. This suggests that the β-CD-enhanced bioremediation process can further be improved by phytoremediation, that could
also allow to simultaneously reach an additional profit from a non-food yield for biofuel production. 相似文献
17.
Summary Capillary electrophoresis has been used for the chiral analysis of two -amino alcohol pharmaceutical compounds. Capillary zone electrophoresis conditions were used with -cyclodextrin as a chiral mobile phase additive. The effects of variation of -cyclodextrin concentration, temperature, pH, background electrolyte composition and concentration have been investigated. Optimum separations were achieved for clenbuterol using -cyclodextrin at its solubility limit (16mM), the lowest practicable temperature (19°C), pH 4.0 and an electrolyte solution with a high ionic strength prepared from 0.1 M citric acid and 0.3 M Na2HPO4. For the development compound picumeterol and its (S)-enationmer, the optimum pH 4.0 buffer was prepared from 0.1 M citric acid and 0.2 M sodium acetate. Baseline separation with resolution greater than 2 was achieved for both compounds.This work was presented in part at the 2nd International Symposium on Chiral Discrimination, Rome, May 27–31, 1991. 相似文献
18.
Xiu-Kui Qu Lan-Ying Zhu Ling Li Xi-Lian Wei Feng Liu De-Zhi Sun 《Journal of solution chemistry》2007,36(5):643-650
As a continuation of our previous investigation, interactions between cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and alkyl trimethylammonium bromides in aqueous solutions have been studied with titration calorimetry and 1H NMR at 298.15 K. The results are discussed in terms of the amphiphilic interaction of CD with surfactants and the iceberg
structure formed by water molecules existing around the hydrophobic tail of surfactant molecules. The stoichiometry of the β-CD–surfactant system is 1:1 whereas that of the γ-CD–surfactant system is 1:2. The corresponding formation enthalpy (negative) of the complexes of the two systems decreases
with an increase in the number of carbon atoms (n) in hydrophobic chain of surfactant molecule, C
n
H2n+1, whereas the entropy increases with the enlargement of n. 相似文献
19.
The cyclodextrins(CDs) are a class of cyclic oligosaccharides made up of six(a), seven(a)or more [a-(1,4)-linked] D-glucopyranose units, and shaped like truncated cones with primary and secondary hydroxyl groups crowning the narrower rim and wider rim respectively. As they have a hydrophobic cavity of appropriate dimension, they can bind with various guest moleculars, such as hydrocarbon, cyclohexane, aromatic compounds, to form inclusion complexes. The cyclodextins inclusion complexation has been considered an ideal model mimicking the enzyme-substrate interaction and a lot of effect has been devoted to it. In this paper, we report our investigation on the inclusion complexation behavior of a-cyclodextrin(a-CD) with diphenyl compounds in order to further explore the molecular recongnition mechanism of 2:1 inclusion complexation of a-CD with aromatic compounds.Figure 1: Possible structures of the inclusion compounds.The inclusion complexation behavior of a-CD with sym-diphenyl-urea, sym-diphenyl-thiourea and diphenyl kotone as respective guest moleclars was studied by ultraviolet spectrometric titrations.The absorption spectral changes observed for the compounds in the absence and presence of a-CD are used to draw the corresponding Benesi-Hildebrand plots and caculate the complex stability constant value (Ks) for the inclusion compounds.The 2:1 inclusion complexations show higher binding constants by cooperative binding of one guest molecular in the closely two hydrophobic cyclodextrin cavites as compared with 1:1 inclusion complexations.The highest value observed for sym-diphenyl-urea could be due to the formation of a hydrogen bond between the carbonyl group and the hydrogen in the hydroxyl group of CD and this is not possible with sym-tiphenyl-thiourea. The lowest value observed for diphenyl kotone indicate the hydrophobic interaction is one of the binding force of cyclodextrin inclusion complex. 相似文献
20.
Jiří Horský Josef Pitha 《Journal of inclusion phenomena and macrocyclic chemistry》1994,18(3):291-300
The stability constants were measured of inclusion complexes formed from aromatic amino acids and their oligopeptides with - and-cyclodextrin, hydroxypropyl-cyclodextrin, and partially methylated-cyclodextrin. The method of competitive spectrophotometry withp-nitrophenol as a competing reagent was used, and measurements were made at pH 7.4-Cyclodextrin formed complexes of higher stability than the other hosts. The stability of complexes of oligopeptides containing L-phenylalanine was invariably higher than that of L-phenylalanine itself. A model for interaction of proteins with cyclodextrins is proposed, in which the most stable complexes are formed when the native functional form of proteins is unfolded and the nonpolar residues that are buried inside the structure are exposed to water. The complexation of the unfolded structure favors its formation; thus thermal denaturation of proteins is easier in the presence of cyclodextrins. On the other hand, this complexation prevents the intermolecular association of unfolded structures by noncovalent hydrophobic bonding between the exposed nonpolar residues; furthermore, the unfolded complexed forms may revert to the native functional form. This prevention of intermolecular association may explain the stabilizing effect of cyclodextrins on solutions of proteins: a return to the native form is achieved more easily from the complexed, unfolded form than from the unfolded, aggregated forms.Dedicated to Professor József Szejtli. 相似文献