液相色谱-质谱用于卵巢肿瘤中磷脂轮廓的分析

卵巢肿瘤日益影响女性的健康和生活质量,其中的卵巢癌是女性三大恶性肿瘤之一,死亡率高居三者之首。因此卵巢肿瘤尤其卵巢癌是目前的一个研究热点。本研究利用液相色谱-质谱(LC-MS)联用技术对卵巢肿瘤进行磷脂轮廓分析,研究良性卵巢肿瘤(B)和卵巢癌(M)的患者血清中磷脂代谢的差异情况。首先用LC-MS采集血清中磷脂的指纹图谱,通过峰识别、峰匹配等得到峰表,然后利用正交校正的偏最小二乘法(OSC-PLS)进行多种分型,根据模型的变量重要因子(VIP)、VIP值的置信区间、S图和显著性差异检验结果等筛选有差异的磷脂。结果显示: M组和B组与正常对照(N)组比较都存在明显的磷脂代谢差异,发生改变的磷脂主要为缩醛磷脂酰乙醇胺、磷脂酰胆碱、缩醛磷脂酰胆碱、鞘磷脂和溶血磷脂酰胆碱。     

Simultaneous Determination of Pethidine and Atropine in Rabbit Plasma by LC�CMS�CMS and Its Application to a Pharmacokinetic Study after Intramuscular Administration

A sensitive and selective liquid chromatography?Ctandem mass spectrometry method for the determination of pethidine and atropine in rabbit plasma was developed and validated. The analytes and internal standard (IS) are extracted from plasma by liquid?Cliquid extraction using ethyl acetate, and separated on a Zorbax SB-Aq column (2.1 × 150 mm, 3.5 ??m) using acetonitrile?C0.1% formic acid as mobile phase with gradient elution. Electrospray ionization source was applied and operated in positive ion mode, and multiple reaction monitoring mode was used for quantification using target fragment ions m/z 247.8 ?? 219.7 for pethidine, m/z 289.9 ?? 123.8 for atropine and m/z 295.0 ?? 266.8 for IS, respectively. The assay is linear over the range of 5?C1,000 ng mL^?1 for pethidine and atropine, with a lower limit of quantification of 3 ng mL^?1 for pethidine and 5 ng mL^?1 for atropine. Intra-day and inter-day precision are less than 11% and the accuracy are in the range of 90.4?C106.3%. Furthermore, the newly developed method is successfully used for the determination of pethidine and atropine in rabbit plasma for pharmacokinetic study.     

Liouville type theorems for a system of integral equations on upper half space

In this paper,we consider the following system of integral equations on upper half space {u(x) = ∫Rn + (1/|x-y|n-α-1/|-y|n-α) λ1up1(y) + μ1vp2(y) + β1up3(y)vp4(y) dy;v(x) = ∫Rn + (1/|x-y|n-α-1/|-y|n-α)(λ2uq1(y) + μ2vq2(y) + β2uq3(y)vq4(y) dy,where Rn + = {x =(x1,x2,...,xn) ∈ Rn|xn 0}, =(x1,x2,...,xn-1,-xn) is the reflection of the point x about the hyperplane xn= 0,0 α n,λi,μi,βi≥ 0(i = 1,2) are constants,pi≥ 0 and qi≥ 0(i = 1,2,3,4).We prove the nonexistence of positive solutions to the above system with critical and subcritical exponents via moving sphere method.     

Crystal structure and standard molar enthalpy of formation of ethylenediamine dilauroleate (C12H24O2)2C2N2H8(s)

The crystal structure of ethylenediamine dilauroleate was determined by X-ray crystallography. A thermochemical cycle was designed in accordance with Hess law. The enthalpy change of the synthesis reaction of ethylenediamine dilauroleate was determined to be $ \Updelta_{{\text{r}}} H_{{\text{m}}}^{\Uptheta } $ Δ r H m Θ  = ?(49.07 ± 0.11) kJ mol^?1 by an isoperibol solution–reaction calorimeter. The standard molar enthalpy of formation of the title compound was calculated to be $ \Updelta_{\text{f}} H_{\text{m}}^{\Uptheta } $ Δ f H m Θ  = ?(38.78 ± 0.43) kJ mol^?1 by the designed thermochemical cycle, the enthalpies of dissolution and other auxiliary thermodynamic quantities.     

Low-temperature heat capacities, and thermodynamic properties of solid–solid phase change material bis(1-octylammonium) tetrachlorocuprate

A new crystalline complex (C₈H₁₇NH₃)₂CuCl₄(s) (abbreviated as C₈Cu(s)) was synthesized by liquid phase reaction. Chemical analysis, elemental analysis, and X-ray crystallography were applied to characterize the composition and crystal structure of the complex. Low-temperature heat capacities of the complex were measured by a precision automatic adiabatic calorimeter over the temperatures ranging from 78 to 395 K, and two solid–solid phase changes appeared in the heat capacity curve. The temperatures, molar enthalpies and entropies of the two phase transitions of the complex were determined to be: T _{trs, 1} = 309.4 ± 0.35 K, Δ_trs H _{m, 1} = 16.55 ± 0.41 kJ mol^?1, and Δ_trs S _{m, 1} = 53.49 ± 1.3 J K^?1 mol^?1 for the first peak; T _{trs, 2} = 338.5 ± 0.63 K, Δ_trs H _{m, 2} = 6.500 ± 0.10 kJ mol^?1, and Δ_trs S _{m, 2} = 19.20 ± 0.28 J K^?1 mol^?1 for the second peak. Two polynomial equations of the heat capacities as a function of the temperature were fitted by least-square method. Smoothed heat capacities and thermodynamic functions of the complex relative to the standard reference temperature of 298.15 K were calculated based on the fitted polynomial equations.     

非线性两能级系统中的Landau-Zener-Coulomb跃迁

非线性跃迁动力学的研究是量子操控中的一个重要课题,在原子分子光物理、量子信息以及固体物理等领域都有着重要的应用.本文研究了具有粒子间相互作用两能级系统中的Landau-Zener-Coulomb跃迁动力学.结果表明,对于能级的斜率正负不同的情况,粒子间相互作用对系统跃迁动力学的影响完全不同.为正时,粒子间相互作用总是抑制能级间的非绝热跃迁,且相互作用强度越大,两能级间的非绝热跃迁越难发生.而为负时,弱相互作用会促进能级间的非绝热跃迁,在强相互作用情况下,跃迁概率会出现振荡.随着相互作用强度的增大,振荡幅度逐渐减小,能级间的非绝热跃迁受到抑制.     

Synthesis and infrared and fluorescence spectra of new europium and terbium polynuclear complexes with an amide-based 1,10-phenanthroline derivative

An amide-based 1,10-phenanthroline (phen) derivative and its complexes with europium(III) and terbium(III) ions were synthesized. The complexes were characterized by elemental analysis, infrared spectra and conductivity. The europium and terbium ions were coordinated by O atoms of C=O, Ar-O-C and N atoms of phen. The fluorescence properties of the complexes in THF, dioxane, MeCN and DMF were investigated. Under the excitation of UV light, these complexes exhibited characteristic fluorescence of europium and terbium ions. The solvent factors influencing the fluorescent intensity were discussed.     

Correlated vortex pinning in Si-nanoparticle doped MgB2

The magnetoresistivity and critical current density of well characterized Si-nanoparticle doped and undoped Cu-sheathed MgB₂ tapes have been measured at temperatures T≥28 K in magnetic fields B≤0.9 T. The irreversibility line B_irr(T) for doped tape shows a stepwise variation with a kink around 0.3 T. Such B_irr(T) variation is typical for high-temperature superconductors with columnar defects (a kink occurs near the matching field B_?) and is very different from a smooth B_irr(T) variation in undoped MgB₂ samples. The microstructure studies of nanoparticle doped MgB₂ samples show uniformly dispersed nanoprecipitates, which probably act as a correlated disorder. The observed difference between the field variations of the critical current density and pinning force density of the doped and undoped tape supports the above findings.     

First synthesis of silicalite-1 from a dry powder system via solid-solid transformation

Silicalite-1 has first been synthesized from a dry powder system with an adsorbedstate template, and is presented as a convincing example for direct solid-solid transformation process.