手性氨基醇催化的前手性芳酮的不对称还原反应

首次以天然D-樟脑的衍生物为原料, 合成了两个新型龙脑基氨基醇配体, 研究了它们与硼烷原位制备成手性噁唑硼烷后, 在不对称催化氢化还原前手性芳酮中的性能, 得到的手性仲醇的对映体过量(ee)值最高可达96%, 还考察了反应温度、时间、溶剂等因素对苯乙酮的不对称氢化还原的化学产率和光学收率的影响.     

N－亚硝基化合物的结构／致癌活性的三维构效关系研究

用比较力场分析研究了Ｎ－亚硝基化合物的结构与致癌活性的关系，考察了网络结构和探针原子对结果的影响．结果表明，立体效应和静电作用场是描述其致癌活性和进行结构性能关系研究的最重要的结构参数。     

碱性介质中高择优取向（220）镍电极上丙醇的电氧化

对１．０ｍｏｌ／ＬＮｉＳＯ４和０．５ｍｏｌ／Ｌ Ｈ３ＢＯ３体系，控制电位为一１．２５Ｖ，沉积６０ｍｉｎ，制得高择优取向镍电极。该镍电极经Ｘ射线衍射测定其织构度ＴＣ２２０为９２％。采用循环伏安法研究了１ｍｏｌ／Ｌ ＮａＯＨ溶液中高择翁取向镍电极上丙醇的电催化氧化机理有活性，结果表明：高择优取向镍电极对正丙醇的电催化活性高，对异丙醇的电催化活性小；推导出正丙醇的电氧化动力学方程，运用稳态极经曲线测定了     

The Study of Anti-tumor Activity of Trichosanthin by Cyclic Voltammogram

IthasbeenreportedthatTrichosanthi11(TCS),isolatedfromrkiI-ilolt)ii,hasanti-tumorI-4andanti-vira1activities5-'.Someanti-tun1orremedies,whicharedesignedfromTCS,arebeingtestedanddeveloped'-.'.StudyingthebioIogicalphenomenonbyelectrochemicalmethodsisanewhotresearchspotemerginginrecentyears".Manyresultsshowedthatnotonlytheenzymesystemsuchassuccinatedehydrogenasedisplayedthediode-likebehaviorduringtheelectrontransferprocess",butalsothehigh1yorganizedorganeIle,forexample,mitochondria,andevenintac…     

一种含氟丙烯酸树脂的制备及其表面疏水性

在聚合反应的后期阶段,向体系中引入含氟丙烯酸酯单体全氟辛基-(N-乙基-N-丙烯酸乙酯基)磺酰胺(QG-F814)共聚改性的方法制备了一种含氟丙烯酸树脂.接触角测定表明,该树脂具有良好的疏水性能.热重分析表明,该树脂在改性前后的耐热稳定性差别不大.     

固体磷酸催化剂的活性相

研究了固体磷酸催化剂活性与其自由磷酸聚合态及磷酸硅晶型的关系，指出高活性磷酸催化剂应具备的条件，即自由磷酸中应为正磷酸和焦磷酸的混合物，结合态磷应具有“Ｃ”晶型。     

制备trans-Fe(CO)_3(PR_3)_2的新的取代过程

报道了用H_2Fe(CO)_4制备trans-Fe(CO)_3(PR_3)_2的新的羰基取代反应。在 过量质子存在下，H_2Fe(CO)_4中的羰基被活化，中心铁原子对膦的亲核进攻更为 敏感。在这种条件下H_2Fe(CO)_4与膦反应时，首先失去氢生成Fe(CO)_4(PR_3), Fe(CO)_4-(PR_3)再与第二个膦反应可高产率的得到trans-Fe(CO)_3(PR_3)_2。用 PPh_3与Fe(CO)_4(PPh_3)在过量质子存在下反应生成trans-Fe(CO)_3(PR_3)_2，证 实了上述过程。     

Microwave-Assisted Soluble Polymer-supported Synthesis of Peptoids

Libraries of peptide-like compounds are attractive sources of binding agents for proteomics applications. The synthesis of oligomeric combinatorial libraries of peptidomimetics is usually more straightforward than the creation of large libraries of more "drug-like" molecules. Herein we report synthesis of peptoids on soluble high loading Noncross-linked polystyrene. The synthesis route consists of: (a) preparation "soluble wang resin" from non-crosslinked polystyrene and 4-hydroxybenzyl alcohol via ether linkage, (b) an esterification step performed by the addition of bromoacetyl bromide to "soluble wang resin" and (c) a nucleophilic displacement of bromide with a primary amine.     

D-型氨基酸的生物法制备

自然界存在20种氨基酸,均为L-型氨基酸,它们是组成蛋白质的基本结构单元.所以,人们一般认为D-氨基酸在自然界中极少存在,因此对于D-氨基酸的功能或性质方面的研究也非常少.近年来,随着科学研究的深入,人们发现非天然的D-型氨基酸虽然不是构成蛋白质的基本结构单元,但许多植物、     

Density of supercritical CO_2-tetrahydrofuran binary mixture and the partial molar volume of the cosolvent

The densities of supercritical CO2-tetrahydrofuran (cosolvent) binary mixture weremeasured at temperatures in range of 308.15 to 323.15 K and at pressure up to 16.5 MPa.The concentrations of tetrahydrofuran were from 0 to 0.57 mol/L.The partial molar volume of tetrahydrofuran was calculated based on the relationship between the density of the mixture and the concentration of the cosolvent.It is observed that the partial molar volume of the cosolvent is negative and the absolute value decreases with increasing pressure and the concentration of the cosolvent.