Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against Herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells

Herpes simplex virus type 1 thymidine kinase (HSV TK) is involved in both antiherpetic therapy and cancer gene therapy with acyclovir (ACV) and ganciclovir (GCV). Enhanced sensitivity to these drugs is advantageous in their clinical use. In the present study, scopadulciol (SDC) and its related compounds were evaluated for their stimulatory effect on the cytotoxicity of ACV and GCV by determination of selective toxicities against HSV TK-expressing HeLa cells. Although SDC remarkably potenciated the cytotoxicity of ACV and GCV, the other tested compounds showed only weak selectivity, except for compound 34.     

Stereo- and Site-Selectivity in the Reaction of Chiral Episelenonium Ion with Carbon Nucleophile

Abstract

There are two important aspects in the reaction of chiral episelenonium ion (episelenonium ion bearing chiral carbon in the three-membered ring) with carbon nucleophile; namely, (1) whether the chiral carbon racemizes during the reaction or not, and (2) the carbon nucleophile attacks the carbon atom (carbophilic attack) or selenium atom (selenophilic attack) in the three-membered ring. When carbon nucleophile such as alkenyl silyl ethers, trimethylsilyl cyanide, and allyltrimethyl-silane are employed, steric protection of the selenium atom by the attachment of tri-tert-butylphenyl (TTBP) group to the selenium atom is inevitable to avoid both of the racemization of the chiral carbon atom and selenophilic attack of the carbon nucleophile. When aromatic compounds are employed as carbon nucleophile, on the other hand, selenophilic attack is rarely observed irrespective of the nature of the aryl group on the selenium atom and introduction of electron withdrawing group into the aryl group on the selenium atom is effective to retard the racemization of the chiral carbon atom.     

Allylation Reactions of Aldehydes with Allylboronates in Aqueous Media: Unique Reactivity and Selectivity that are Only Observed in the Presence of Water

Zn(OH)₂‐catalyzed allylation reactions of aldehydes with allylboronates in aqueous media have been developed. In contrast to conventional allylboration reactions of aldehydes in organic solvents, the α‐addition products were obtained exclusively. A catalytic cycle in which the allylzinc species was generated through a B‐to‐Zn exchange process is proposed and kinetic studies were performed. The key intermediate, an allylzinc species, was detected by HRMS (ESI) analysis and by online continuous MS (ESI) analysis. This analysis revealed that, in aqueous media, the allylzinc species competitively reacted with the aldehydes and water. An investigation of the reactivity and selectivity of the allylzinc species by using several typical allylboronates ( 6a , 6b , 6c , 6d ) clarified several important roles of water in this allylation reaction. The allylation reactions of aldehydes with allylboronic acid 2,2‐dimethyl‐1,3‐propanediol esters proceeded smoothly in the presence of catalytic amounts of Zn(OH)₂ and achiral ligand 4d in aqueous media to afford the corresponding syn‐adducts in high yields with high diastereoselectivities. In all cases, the α‐addition products were obtained and a wide substrate scope was tolerated. Furthermore, this reaction was applied to asymmetric catalysis by using chiral ligand 9 . Based on the X‐ray structure of the Zn‐ 9 complex, several nonsymmetrical chiral ligands were also found to be effective. This reaction was further applied to catalytic asymmetric alkylallylation, chloroallylation, and alkoxyallylation processes and the synthetic utility of these reactions has been demonstrated.     

Transformation of environment map by changing the captured position in a cuboidal room

Optical Review - In this paper, we consider the use of an environment map as a photographic support tool for understanding the condition of surrounding light. It is well known that an environment...     

Recognition and one-pot extraction of right- and left-handed semiconducting single-walled carbon nanotube enantiomers using fluorene-binaphthol chiral copolymers

Synthesized single-walled carbon nanotubes (SWNTs) are mixtures of right- and left-handed helicity and their separation is an essential topic in nanocarbon science. In this paper, we describe the separation of right- and left-handed semiconducting SWNTs from as-produced SWNTs. Our strategy for this goal is simple: we designed copolymers composed of polyfluorene and chiral bulky moieties because polyfluorenes with long alkyl-chains are known to dissolve only semiconducting SWNTs and chiral binaphthol is a so-called BINAP family that possesses a powerful enantiomer sorting capability. In this study, we synthesized 12 copolymers, (9,9-dioctylfluorene-2,7-diyl)x((R)- or (S)-2,2'-dimethoxy-1,1'-binaphthalen-6,6-diyl)y, where x and y are copolymer composition ratios. It was found that, by a simple one-pot sonication method, the copolymers are able to extract either right- or left-handed semiconducting SWNT enantiomers with (6,5)- and (7,5)-enriched chirality. The separated materials were confirmed by circular dichroism, vis-near IR and photoluminescence spectroscopies. Interestingly, the copolymer showed inversion of SWNT enantiomer recognition at higher contents of the chiral binaphthol moiety. Molecular mechanics simulations reveal a cooperative effect between the degree of chirality and copolymer conformation to be responsible for these distinct characteristics of the extractions. This is the first example describing the rational design and synthesis of novel compounds for the recognition and simple sorting of right- and left-handed semiconducting SWNTs with a specific chirality.     

Single-step thioetherification by indium-catalyzed reductive coupling of carboxylic acids with thiols

Direct thioetherification from a variety of aromatic carboxylic acids and thiols using a reducing system combined with InBr(3) and 1,1,3,3-teramethyldisiloxane (TMDS) in a one-pot procedure is demonstrated. It was also found that a system combined with InI(3) and TMDS underwent thioetherification of aliphatic carboxylic acids with thiols.     

Observation of the quantum Hall effect in cleaved InAs surfaces

We have performed the in-plane magnetotransport measurements on the two-dimensional electron gas at the cleaved p-InAs (1 1 0) surface by deposition of Ag. The surface electron density N_s is determined from the Hall coefficient at . The coverage dependence of N_s is well explained by the assumption that each adsorbed Ag atom denotes one electron into InAs until the surface Fermi level reaches the adsorbate-induced donor level. The electron mobility μ is about and does not show a clear dependence on the coverage over . In the high-magnetic field regime of B>1/μ, Shubnikov–de Hass oscillations were observed. A beating pattern due to the strong spin–orbit interaction appears for high N_s. For lower N_s of , an apparent quantum Hall plateau for ν=4 and vanishing of the longitudinal resistivity were observed around .     

Extraction of object position from in-line holograms by using single wavelet coefficient

A novel digital method for tracking position of objects from in-line holograms by using single wavelet coefficient is proposed. In the proposed method, a wavelet transform is used to analyze the holograms. An axial position of the object being studied is determined by using a real value of a resultant wavelet coefficient appears at a center position of interference fringes. A feasibility of this method is experimentally verified by analyzing holograms of an optical fiber.