Synthesis,Antimicrobial Evaluation,and Docking Studies of Substituted Acetylphenoxymethyl‐triazolyl‐N‐phenylacetamides

A series of molecules containing acetylphenoxymethyl, triazole, and N‐phenylacetamide moieties were synthesized via the click chemistry approach. All the synthesized compounds were screened for their antimicrobial activities in vitro. The synthesized compounds 8a , 8b , 8m , and 8n showed better activities. We further performed exploratory docking studies to gain some insight regarding the molecular mechanism of antibacterial action of these compounds that could guide further structure‐activity relationship (SAR) studies. We examined the interaction of the most active compound with DNA gyrase (pdb id:1KZN). Based on antimicrobial and docking studies, the compounds 8a , 8b , 8m , and 8n were identified as potential antimicrobial agents.     

Electrostatic cnoidal waves and soliton structures in multi‐ions plasmas

Using a reductive perturbation technique (RPT), the Korteweg‐de Vries (KdV) equation for nonlinear electrostatic waves in multi‐ion plasmas is derived with appropriate boundary conditions. Furthermore, compressive and rarefactive cnoidal wave and soliton solutions are discussed. In our model, the multi‐ion plasma consists of light dynamic warm ions, heavy cold ions, and inertialess electrons, which follows the Maxwell‐Boltzmann distribution. It is observed that in such an unmagnetized multi‐ion plasma, two characteristic electrostatic waves i.e., slow ion‐acoustic (SIA) waves and fast ion‐acoustic (FIA) waves, can propagate. The results are discussed by considering two types of multi‐ion plasmas i.e., H⁺–O⁺–e plasma and H^?–O⁺–e plasma that exist in space plasmas. It is found that for H⁺–O⁺–e plasma, the SIA cnoidal wave and soliton form both positive (compressive) and negative (rarefactive) potential pulses, which depend on the temperature and density of the light and warm ions. However, only electrostatic positive potential structures are obtained for FIA cnoidal wave and soliton in H⁺–O⁺–e plasma. In the case of H^?–O⁺–e plasma, the SIA cnoidal wave and soliton form only compressive structures, while the FIA cnoidal wave and soliton compose rarefactive structures. The effects of light ions' density and temperature on nonlinear potential structures are investigated in detail. The parametric results are also demonstrated, which are applicable to space and laboratory multi‐ion plasma situations.     

New classes of anisotropic models with generalized polytropic equation of state

In this paper, we investigate the gravitational behavior of compact objects with the help of generalized polytropic equation of state in isotropic coordinates. We found three exact solutions of Einstein field equations by taking into account the different values of polytropic index with spherically symmetric anisotropic inner fluid distribution. We have regained the masses of PSR \(\hbox {J}1614-2230\), Vela X-1, Vela 4U, PSR J1903+327 and 4U 1820-30. Speed of sound has been used to analyze the stability of models. The comprehensive analysis indicates that all the models are physically viable and well behaved.     

Assessment of bilayer silicene to probe as quantum spin and valley Hall effect

Silicene takes precedence over graphene due to its buckling type structure and strong spin orbit coupling. Motivated by these properties, we study the silicene bilayer in the presence of applied perpendicular electric field and intrinsic spin orbit coupling to probe as quantum spin/valley Hall effect. Using analytical approach, we calculate the spin Chern-number of bilayer silicene and then compare it with monolayer silicene. We reveal that bilayer silicene hosts double spin Chern-number as compared to single layer silicene and therefore accordingly has twice as many edge states in contrast to single layer silicene. In addition, we investigate the combined effect of intrinsic spin orbit coupling and the external electric field, we find that bilayer silicene, likewise single layer silicene, goes through a phase transitions from a quantum spin Hall state to a quantum valley Hall state when the strength of the applied electric field exceeds the intrinsic spin orbit coupling strength. We believe that the results and outcomes obtained for bilayer silicene are experimentally more accessible as compared to bilayer graphene, because of strong SO coupling in bilayer silicene.     

Structural, energetic, and electronic properties of Sin, Gen, and SinGen clusters

Results of a theoretical study of the properties of Si_n, Ge_n, and Si_nGe_n clusters are presented. An approximate density-functional method in combination with genetic algorithms have been used in an unbiased determination of the structures of the lowest total energy. The resulting structural, energetic, and electronic properties are analysed and compared with each other for the different systems.     

Stability of Quark Star Models

In this paper,we investigate the stability of quark stars with four different types of inner matter configurations;isotropic,charged isotropic,anisotropic and charged anisotropic by using the concept of cracking.For this purpose,we have applied local density perturbations technique to the hydrostatic equilibrium equation as well as on physical parameters involved in the model.We conclude that quark stars become potentially unstable when inner matter configuration is changed and electromagnetic field is applied.     

Non‐catalytic,gas‐solid reversible reaction mechanism implementing diffuse interface model

Gas‐solid reactions in chemical and metallurgical industries often involve solid pellets and a gaseous reactant. The progress of chemical reaction is measured by the movement of zones within the pellet and has been explained in terms of diffusion and chemical reaction processes. Earlier models identified a single reaction zone, in addition to product layer and unreacted core. In the present article, two reaction zones are envisaged as a more plausible explanation of the movement of the zones as the reaction proceeds. Earlier models for reversible reactions have assumed that conditions at the interface between the reaction zone and the unreacted core correspond to equilibrium at the prevailing temperature. The gaseous concentrations were assumed to permeate the core at the interfacial values so that no reaction occured in the core. More realistically, the present article envisages an additional zone within which the gaseous concentrations fall from the equilibrium values to zero. It is assumed that in the reaction zone proper, referred to as zone I, having thickness z_I, the concentration profile is sigmoidal. This agrees with the earlier work of Khan and Bowen [1] and Prasannan and Doraswamy. [2] In zone I and the concentration of the reactant gas varies between [A_i] and [A*]. In the zone II, having thickness z₂, concentration varies linearly between [A*] and zero. This model has been applied successfully to the data of the reduction of hematite [3] at different temperatures. The contribution of different forms of resistance, diffusion in product layer, chemical reaction and diffusion in the reactant core, is assessed as function of time (start to the end of reaction). The thickness of the zones remain almost constant as the reaction progresses. In particular, the influences of the product and core diffusion coefficients and chemical equilibrium constant on the extant reaction are evaluated. The dependence of concentration profile and zone thickness on equilibrium constant, K, velocity constant, k, diffusional coefficients D_C and D_P has been investigated thoroughly. The thickness of both zones has been evaluated for leading variables. © 1999 John Wiley & Sons, Inc. Int J Chem Kinet 31: 559–570, 1999     

Anticancer Properties of Eugenol: A Review

Conventional cancer treatments have shown several unfavourable adverse effects, as well as an increase in anticancer drug resistance, which worsens the impending cancer therapy. Thus, the emphasis is currently en route for natural products. There is currently great interest in the natural bioactive components from medicinal plants possessing anticancer characteristics. For example, clove (Syzygium aromaticum L.) (Family Myrtaceae) is a highly prized spice that has been historically utilized as a food preservative and for diverse medical uses. It is reckoned amongst the valued sources of phenolics. It is indigenous to Indonesia but currently is cultivated in various places of the world. Among diverse active components, eugenol, the principal active component of S. aromaticum, has optimistic properties comprising antioxidant, anti-inflammatory, and anticancer actions. Eugenol (4-allyl-2-methoxyphenol) is a musky oil that is mainly obtained from clove. It has long been utilized all over the world as a result of its broad properties like antioxidant, anticancer, anti-inflammatory, and antimicrobial activities. Eugenol continues to pique investigators’ interest because of its multidirectional activities, which suggests it could be used in medications to treat different ailments. Anticancer effects of eugenol are accomplished by various mechanisms like inducing cell death, cell cycle arrest, inhibition of migration, metastasis, and angiogenesis on several cancer cell lines. Besides, eugenol might be utilized as an adjunct remedy for patients who are treated with conventional chemotherapy. This combination leads to a boosted effectiveness with decreased toxicity. The present review focuses on the anticancer properties of eugenol to treat several cancer types and their possible mechanisms.     

Ascorbic Acid and Salicylic Acid Mitigate NaCl Stress in Caralluma tuberculata Calli

Plants exposed to salt stress undergo biochemical and morphological changes even at cellular level. Such changes also include activation of antioxidant enzymes to scavenge reactive oxygen species, while morphological changes are determined as deformation of membranes and organelles. Present investigation substantiates this phenomenon for Caralluma tuberculata calli when exposed to NaCl stress at different concentrations. Elevated levels of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) in NaCl-stressed calli dwindled upon application of non-enzymatic antioxidants; ascorbic acid (AA) and salicylic acid (SA). Many fold increased enzymes concentrations trimmed down even below as present in the control calli. Electron microscopic images accentuated several cellular changes upon NaCl stress such as plasmolysed plasma membrane, disruption of nuclear membrane, increased numbers of nucleoli, alteration in shape and lamellar membrane system in plastid, and increased number of plastoglobuli. The cells retrieved their normal structure upon exposure to non-enzymatic antioxidants. The results of the present experiments conclude that NaCl aggravate oxidative molecules that eventually alleviate antioxidant enzymatic system. Furthermore, the salt stress knocked down by applying ascorbic acid and salicylic acid manifested by normal enzyme level and restoration of cellular structure.     

Sorption Studies of Nickel ions Onto Sawdust of Dalbergia Sissoo

Sawdust of Dalbergia sissoo, a byproduct of sawmills, was found to be a promising adsorbent for the removal of nickel ions from aqueous solution. Sorption of nickel ions onto sawdust of Dalbergia sissoo was studied using the batch technique. Kinetics studies show that nickel ions sorption process obeys a first order rate law. The applicability of the Langmuir and Freundlich models for the data was tested. Both the models adequately describe the experimental data of the biosorption of nickel ions. The sorption capacities and energies were calculated. Langmuir parameters X_m and K₁ were found to increase with rise in temperature; Freundlich constants 1/n and K_f have been evaluated for 293K, 303K, 313K and 323K. Thermodynamic parameter ΔH° = 4.80 kJ mol^?;1 shows that sorption of nickel ions onto sawdust is an endothermic process.