Objective: Neuromuscular electrical stimulation (NMES) has been noted as an effective pre- contraction for an increase of neural and muscle factors during twitch contractions. However, it is unknown if this intervention is effective for the rate of force development (RFD), which is the ability to increase joint torque strength as quickly as possible, during tetanic contractions. NMES can be safely used by anyone, but, the strength setting of NMES requires attention so as not to cause pain. Therefore, the purpose of this study investigated whether NMES at less painful levels was effective for RFD during tetanic contractions. We also investigated effect activation by analyzing electromyogram (EMG) and RFD for each phase. Methods: Eighteen healthy males were studied. Before and after NMES intervention at 10% or 20% maximal voluntary isometric contraction (MVIC) level (10%NMES, 20%NMES respectively), EMG activity and the initial phase (30-, 50-, 100-, and 200-msec) RFD were measured. Visual analog scale (VAS) was also measured as an indicator of pain during each NMES. Results: 20%NMES increased EMG activity and 30-, 50-, and 100-msec of RFD during MVIC, but could not improve 200 msec of RFD. However, 10%NMES could be failed to increase all phases RFD, but VAS was lower than that of 20% NMES. Conclusion: These results suggest that muscle pre-contraction using 20%NMES could induce moderate pain, but could be an effective intervention to improve RFD via neural factor activity. 相似文献
Furoxans are distinctive heteroaromatic compounds in that they are potentially capable of releasing nitric oxide under physiological conditions. In order to utilize the furoxan scaffold for the development of functional molecules, synthetically relevant functional groups are required for access to diverse furoxans. In this report, a facile route to furoxans with sulfonyloxy groups, which are halide surrogates, has been developed. The key features of this strategy include the synthesis and utilization of bench-stable hydroxyfuroxan salts, the use of sulfonyl anhydrides in the sulfonylation step instead of sulfonyl chlorides, and the photochemical isomerization of one regioisomer to another in order to gain access to both. 相似文献
Muscle cells take either one of two states, namely contraction (on-state) and relaxation (off-state), under a particular physiological condition (physiological ionic strength, neutral pH and a few mM MgATP). The transition between these two states is regulated by micromolar concentrations of free Ca2+. Here we review spontaneous oscillation phenomena named SPOC. The SPOC state is attained in a contractile system of muscle (muscle model without cell membrane) as a third intermediate state. It appears either at an intermediate concentration of free Ca2+ (Ca-SPOC) or under the coexistence of MgATP with its hydrolytic products, i.e., MgADP and inorganic phosphate (Pi), where Ca2+ is not required (ADP-SPOC). We have constructed a three-dimensional Phase diagram showing three regions corresponding to three states of muscle realized under various concentrations of MgADP, Pi and free Ca2+ in the presence of MgATP; the SPOC region was sandwiched between contraction and relaxation regions. We tried to understand the mechano-chemical coupling in SPOC by explaining the mechanical properties of SPOC based on a standard kinetic scheme of actomyosin ATPase; the experimental results could be well simulated, except for the function of Pi, by assuming that a particular kinetic step regulated by Ca2+ is also regulated by the feed-back effect of the actomyosin-ADP complex. It is suggested that the SPOC state is attained by cyclic transition among the different chemical states of the actomyosin complex within each half-sarcomere, which occurs spontaneously through the mechanochemical coupling characteristic to the actomyosin complex, i.e., a mechano-enzyme. 相似文献
ABSTRACTBoth micro-paired and conical support type double-stage diamond anvil cells (ds-DAC) were tested using a newly synthesized ultra-fine nano-polycrystalline diamond (NPD). Well-focused X-ray sub-micron beam and the conically supported 2nd stage anvils (micro-anvils) with 10?μm culet enable us to obtain good quality X-ray diffraction peaks from the sample at around 400?GPa. The relationship between confining pressure and sample pressure depends heavily on the initial height (thickness) of micro-anvils, the difference of a few micrometers leads to a quite different compression path. The conical support type is a solution to retain both enough thickness and strength of micro-anvils at higher confining pressure conditions. All conical support ds-DAC experiments terminated by the failure of the 1st stage anvil instead of 2nd one. The combination of ultra-fine NPD 2nd stage anvil and NPD 1st stage anvil opens a new frontier for measurement of the X-ray absorption spectrum above 300?GPa. 相似文献
Lithium phosphorus oxynitride (LiPON) is an amorphous solid-state lithium ion conductor displaying exemplary cyclability against lithium metal anodes. There is no definitive explanation for this stability due to the limited understanding of the structure of LiPON. Herein, we provide a structural model of RF-sputtered LiPON. Information about the short-range structure results from 1D and 2D solid-state NMR experiments. These results are compared with first principles chemical shielding calculations of Li-P-O/N crystals and ab initio molecular dynamics-generated amorphous LiPON models to unequivocally identify the glassy structure as primarily isolated phosphate monomers with N incorporated in both apical and as bridging sites in phosphate dimers. Structural results suggest LiPON′s stability is a result of its glassy character. Free-standing LiPON films are produced that exhibit a high degree of flexibility, highlighting the unique mechanical properties of glassy materials. 相似文献
Journal of Inclusion Phenomena and Macrocyclic Chemistry - Ketoprofen is a nonsteroidal anti-inflammatory drug used as mohrus tape which causes unwanted photosensitivity due to UV irradiation. In... 相似文献
Cellulose, the main component of plant cell walls, is degradable in nature. However, to the best of our knowledge, this is the first report that compares the biodegradability of cellulose fibers with different structures in natural waters. River water, brackish water, and seawater were collected from the Kamo River and Osaka Bay, Japan. Biodegradation of cellulose fibers with different structures and crystallinities, ramie, mercerized ramie, and regenerated cellulose fibers in the collected natural water was investigated in the dark at 20 °C for 30 days. The primary and aerobic ultimate biodegradability were evaluated by weight loss and biochemical oxygen demand (BOD) tests, respectively. In the weight-loss test, cellulose fibers were found to be degraded by more than 50% in any natural water within 30 days. However, in the BOD test, biodegradation was diminished, with values of 40%, 20–30%, and 2–10% in river water, brackish water, and seawater, respectively. These results indicate that cellulose fibers are easily degraded into fine fragments, but it is difficult to cause their ultimate decomposition into water and carbon dioxide. Existence of such a tendency in the degree of biodegradation among the cellulose fibers remains unclear. The molecular weight of cellulose fibers in natural water was also measured during their degradation. The degradation behavior in river water and seawater was observed to be different from that in brackish water. The results thus obtained indicate that the microorganisms and enzymes that degrade cellulose fibers differ depending on the natural water, which influences the degree and mechanism of biodegradation.
Electropolymerization of water-insoluble monomers, such as 3,4-ethylenedioxythiophene (EDOT), 3,4-dimethylthiophene (3,4-DiMeTh), 3-methylthiophene (3-MeTh), and 3-ethylthiophene (3-EtTh), proceeded successfully in aqueous electrolytes using acoustic emulsification. Ultrasonication to the water-insoluble monomer/aqueous electrolyte mixtures allowed the formation of very stable emulsions having the characteristic of giving narrow monomer droplet size distributions in the submicrometer range in aqueous electrolytes without added surfactants, and the smooth electropolymerization in the emulsions took place via direct electron transfer between the electrode and the water-insoluble monomer droplets. In this kind of electron-transfer system, the supporting electrolyte should be dissolved not only in the aqueous phase but also in the monomer droplets and contribute to the formation of an electric bilayer inside the droplets. The properties of a polymer EDOT film obtained by the present method were also investigated. 相似文献