Finite element modeling of the mechanical effects of the UV laser ablation of polymer coatings

Laser ablation constitutes the basis of a number of techniques aiming at the processing and diagnosis of polymeric coatings on a variety of substrates. In all these applications, however, the issue is raised about the mechanical effects of the procedure on the substrate integrity. To this end, we employ finite element modeling for simulating the mechanical effects of UV laser ablation on a polymer specimen, with particular emphasis on the structural modifications that may be induced at areas away from the ablation spot. The cylindrical specimen consists of a poly(methylmethacrylate) (PMMA) film on a silica substrate. The analysis shows that stresses of high enough amplitude may propagate to distances far away from the irradiated spot and may induce deleterious mechanical deformations (e.g., cracks or delaminations). The dependence of the distribution of the tensile stresses on the thickness of the two components, as well as on size of the ablation spot area, is examined. Finally, the possibility of growth of pre-existing defects is shown. The results are overall in very good agreement with experimental observations.     

Newtonian plane Couette flow with dynamic wall slip

Meccanica - The occurrence of slip complicates the estimation of the viscosity in rheometric flows. Thus, special analyses and experimental protocols are needed in order to obtain reliable...     

Rational Design and Synthesis of AT1R Antagonists

Hypertension is one of the most common diseases nowadays and is still the major cause of premature death despite of the continuous discovery of novel therapeutics. The discovery of the Renin Angiotensin System (RAS) unveiled a path to develop efficient drugs to fruitfully combat hypertension. Several compounds that prevent the Angiotensin II hormone from binding and activating the AT1R, named sartans, have been developed. Herein, we report a comprehensive review of the synthetic paths followed for the development of different sartans since the discovery of the first sartan, Losartan.     

A study concerning splitting and jointly continuous topologies on C(Y,Z)

Let Y and Z be two fixed topological spaces and C(Y, Z) the set of all continuous maps from Y into Z. We construct and study topologies on C(Y, Z) that w^{e call F}n(τn)-family-open topologies. Furthermore, we find necessary and su?cient conditions such that these topologies to be splitting and jointly continuous. Finally, we present questions concerning a further study on this area.     

A study of the order dimension of a poset using matrices

In every finite poset (X, ≤) we assign the so called order-matrix , where α_ij ∈ {?2, 0, 1, 2}. Using this matrix, we characterize the order dimension of an arbitrary finite poset.     

Using singlet oxygen to synthesise a [6,6,5]-bis-spiroketal in one-pot from a simple 2,5-disubstituted furan

Singlet oxygen (1O2) proves to be a powerful tool in mediating the one-pot synthesis of a salinomycin-type [6,6,5]-bis-spiroketal unit starting from a suitably substituted furan nucleus.     

A unified framework for the numerical solution of general quadratic matrix equations

^** Email: vassilios.tsachouridis{at}ieee.org^*** Email: N.karcanias{at}city.ac.uk^**** Email: ixp{at}le.ac.uk Algebraic quadratic equations are special cases of a singlegeneralized algebraic quadratic matrix equation (GQME). Thispaper focuses on the numerical solution of the GQME using probability-1homotopy methods. A synoptic review of these methods and theirapplication to algebraic matrix equations is provided as background.A large variety of analysis and design problems in systems andcontrol are reported as special cases of the presented frameworkand some of them are illustrated via numerical examples fromthe literature.     

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro

Acute myeloid leukemia (AML) is the most aggressive type of blood cancer, and there is a continued need for new treatments that are well tolerated and improve long-term survival rates in patients. Induction of differentiation has emerged as a promising alternative to conventional cytotoxic chemotherapy, but known agents lack efficacy in genetically distinct patient populations. Previously, we established a phenotypic screen to identify small molecules that could stimulate differentiation in a range of AML cell lines. Utilising this strategy, a 1,5-dihydrobenzo[e][1,4]oxazepin-2(3H)-one hit compound was identified. Herein, we report the hit validation in vitro, structure-activity relationship (SAR) studies and the pharmacokinetic profiles for selected compounds.