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71.
Zhengxiao Zhang Prof. Eiji Nakata Dr. Huyen Dinh Dr. Masayuki Saimura Prof. Arivazhagan Rajendran Prof. Kazunari Matsuda Prof. Takashi Morii 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(72):18118-18128
Recognition-driven modification has been emerging as a novel approach to modifying biomolecular targets of interest site-specifically and efficiently. To this end, protein modular adaptors (MAs) are the ideal reaction model for recognition-driven modification of DNA as they consist of both a sequence-specific DNA-binding domain (DBD) and a self-ligating protein-tag. Coupling DNA recognition by DBD and the chemoselective reaction of the protein tag could provide a highly efficient sequence-specific reaction. However, combining an MA consisting of a reactive protein-tag and its substrate, for example, SNAP-tag and benzyl guanine (BG), revealed rather nonselective reaction with DNA. Therefore new substrates of SNAP-tag have been designed to realize sequence-selective rapid crosslinking reactions of MAs with SNAP-tag. The reactions of substrates with SNAP-tag were verified by kinetic analyses to enable the sequence-selective crosslinking reaction of MA. The new substrate enables the distinctive orthogonality of SNAP-tag against CLIP-tag to achieve orthogonal DNA-protein crosslinking by six unique MAs. 相似文献
72.
A methodology to perform a ghost-cell-based immersed boundary method (GCIBM) is presented for simulating compressible turbulent flows around complex geometries. In this method, the boundary condition on the immersed boundary is enforced through the use of ‘ghost cells’ that are located inside the solid body. The computations of variables on these ghost cells are achieved using linear interpolation schemes. The validity and applicability of the proposed method is verified using a three-dimensional (3D) flow over a circular cylinder, and a large-eddy simulation of fully developed 3D turbulent flow in a channel with a wavy surface. The results agree well with the previous numerical and experimental results, given that the grid resolution is reasonably fine. To demonstrate the capability of the method for higher Mach numbers, supersonic turbulent flow over a circular cylinder is presented. While more work still needs to be done to demonstrate higher robustness and accuracy, the present work provides interesting insights using the GCIBM for the compressible flows. 相似文献
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Hai Q. Dinh Xiaoqiang Wang Hongwei Liu Songsak Sriboonchitta 《Discrete Mathematics》2019,342(5):1456-1470
Let be an odd prime, , be positive integers, be nonzero elements of the finite field such that . In this paper, we show that, for any positive integer , the Hamming distances of all repeated-root -constacyclic codes of length can be determined by those of certain simple-root -constacyclic codes of length . Using this result, Hamming distances of all constacyclic codes of length are obtained. As an application, we identify all MDS -constacyclic codes of length . 相似文献
75.
Iseul Jeong Chae Bin Kim Dong‐Gue Kang Kwang‐Un Jeong Se Gyu Jang Nam‐Ho You Seokhoon Ahn Dai‐Soo Lee Munju Goh 《Journal of polymer science. Part A, Polymer chemistry》2019,57(6):708-715
To address tremendous needs for developing efficiently heat dissipating materials with lightweights, a series of liquid crystalline epoxy resins (LCEs) are designed and synthesized as thermally conductive matrix. All prepared LCEs possess epoxies at the molecular side positions and cyanobiphenyl mesogenic end groups. Based on several experimental results such as differential scanning calorimetry, polarized optical microscopy, and X‐ray diffraction, it is found that the LCEs exhibited liquid crystalline mesophases. When LCE is cured with a diamine crosslinker, the cured LCE maintains the oriented LC domain formed in the uncured state, ascribing to a presence of dipole–diploe and π–π interactions between cyanobiphenyl mesogenic end groups. Due to the anisotropic molecular orientation, the cured LCE exhibits a high thermal conductivity of 0.46 W m?1 K?1, which is higher than those of commercially available crystalline or amorphous epoxy resins. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57, 708–715 相似文献
76.
Simple scaling laws for the design parameters of plasma wakefield accelerators were obtained using a theoretical model, which were confirmed via particle simulation studies. It was found that the acceleration length was given by Δx=0.804λp/(1−βg), where λp is the plasma wavelength and βgc the propagation velocity of the ion cavity. The acceleration energy can also be given by ΔE=(γm−1)mc2=2.645mc2/(1−βg), where m is the electron rest mass. As expected, the acceleration length and energy increase drastically as βg approached unity. These simple scaling laws can be very instrumental in the design of better-performing plasma wakefield accelerators. 相似文献
77.
Fabián Flores-Bazán Dinh The Luc Antoine Soubeyran 《Journal of Optimization Theory and Applications》2012,155(3):883-901
We study reference-dependent preference relations defined by a real-valued bivariate function and prove an existence criterion for maximal elements. Then we formulate a generalized version of the well-known Brondsted maximum principle and apply it to behavioral traps and Nash equilibrium in games with preference relations that are not necessarily partial orders. 相似文献
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Tang Guangxian Shafee Ahmad Nam Nguyen Dang Tlili Iskander 《Journal of Thermal Analysis and Calorimetry》2021,143(6):4249-4260
Journal of Thermal Analysis and Calorimetry - Electrical sensor has been considered in the current attempt. Combination of buoyancy, electric and radiative forces has been included in the governing... 相似文献
80.