Cyanine-based probe-possessing indolium iodide and indole unit were synthesized in two-step with easy available raw material: a potential probe for the cyanide ion detection. The detecting ability of the probe was investigated and confirmed by a visual and instrumental approach. A noticeable color change from orange to colorless obtained only for cyanide ions and other added ions does not impart any changes visually and through UV and Fluorescence technique. To confirm the mechanism of sensing 1H-NMR recorded. From the result, the peak belonging to N-methyl displayed an upfield shift from 4.01 δ ppm to 2.74 δ ppm due to the disappearance of indolium iodide ion and the olefin protons peaks were shifted from 7.19 to 6.17 and 8.70 to 7.20 δ ppm confirms the nucleophilic addition of cyanide ion to the probe. Test kit from filter paper prepared for the real-time monitoring cyanide ion. The prepared strip is effective in detecting cyanide ion with a visual color change.
Catalyst-free synthesis of the isoxazole-spirooxindole-tetrahydrothiophene hybrids is reported. Formation of 1,4-thia-Michael and intramolecular aldol reactions were observed (instead of 1,6-thia-Michael followed by vinylogous Henry reactions) in a regioselective fashion to give new isoxazole-spirooxindole-tetrahydrothiophene hybrids with excellent yields. 相似文献
This work describes a mild and robust double hydroarylation strategy for the synthesis of symmetrical /unsymmetrical diaryl- and triarylmethanes in excellent yields using Lambert salt (0.2–1.0 mol%). Despite the anticipated challenges associated with controlling selective product formation, unsymmetrical diaryl- and triarylmethanes products are obtained unprecedentedly. A highly efficient gram scale reaction has also been reported (TON for symmetrical product=475 and for unsymmetrical product=390). The synthetic utility of the methodology is demonstrated by the preparation of several unexplored diaryl- and triarylmethane-based biologically relevant molecules, such as arundine, vibrindole A, turbomycin B, and certain anti-inflammatory agents. A total synthesis of an anti-breast-cancer agent is also demonstrated. Control experiments, Hammett analysis, HRMS and GC-MS studies reveal the reaction intermediates and reaction mechanism. 相似文献
Russian Journal of General Chemistry - In the present study, we report the synthesis of 5-[4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole derivatives by the Michael addition of... 相似文献
Catalysis Surveys from Asia - Catalytic production of ethyl levulinate by alcoholysis of furfuryl alcohol with ethanol was investigated over H-mordenite supported Sn catalyst under atmospheric N2... 相似文献
A one‐step synthetic method was developed for allylation of benzamides using Ni(COD)2/RCO2H and [Ni(μ‐H2O)(OOCCMe3)2(HOOCCMe3)2]2 ( A′ ) catalytic system. Efficient, well‐defined, air and moisture‐stable Ni–pivalate complex was isolated and employed in catalytic allylation. The influence of solvent on product selectivity was also investigated. 相似文献
Hydrolysis of TiCl4 in a diether‐functionalized imidazolium ionic liquid (IL), namely 1‐methyl‐3‐[2‐(2‐methoxy(ethoxy)ethyl]imidazolium methane sulfonate (M(MEE)I ? CH3SO3), results in a heterostructured organic/inorganic and sponge‐like porous TiO2 material. The thermal treatment (300 °C) followed by calcination (500 °C) affords highly porous TiO2. The characterization of the obtained samples (with and without IL, before and after calcination) by XRD, SEM, and TEM reveals TiO2 anatase crystalline phases and irregular‐shaped particles with different porous structures. These hierarchical‐structured mesoporous TiO2 nanomaterials were employed as efficient photocatalysts in the water‐splitting process, yielding up to 1304 μmol g?1 on hydrogen production. 相似文献
Basmati rice is a very special type of aromatic rice known world-wide for its extra long grains and pleasant and distinct aroma. Traditional Basmati rice cultivars, confined to Indo-Gangetic regions of the Indian subcontinent, are often reported to be adulterated with crossbred Basmati varieties and long-grain non-Basmati varieties in the export market. At present, there is no commercial scale technology to reliably detect adulteration. We report here a CE-based multiplex microsatellite marker assay for detection as well as quantification of adulteration in Basmati rice samples. The single-tube assay multiplexes eight microsatellite loci to generate variety-specific allele profiles that can detect adulteration from 1% upwards. The protocol also incorporates a quantitative-competitive PCR-based analysis for quantification of adulteration. Accuracy of quantification has been shown to be +/-1.5%. The experiments used to develop and validate the methodology are described. 相似文献
Summary This study sheds new light on the role of acidic residues present in the active site cavity of human aromatase. Eight acidic
residues (E129, D222, E245, E302, D309, E379, D380 and D476) lining the cavity are identified and studied using comparative
modeling, docking, molecular dynamics as well as statistical techniques. The structural environment of these acidic residues
is studied to assess the stability of the corresponding carboxylate anions. Results indicate that the environment of the residues
E245, E302 and D222 is most suitable for carboxylate ion formation in the uncomplexed form. However, the stability of D309,
D222 and D476 anions is seen to increase on complexation to steroidal substrates. In particular, the interaction between D309
and T310, which assists proton transfer, is found to be formed following androgen/nor-androgen complexation. The residue D309
is found to be clamped in the presence of substrate which is not observed in the case of the other residues although they
exhibit changes in properties following substrate binding. Information entropic analysis indicates that the residues D309,
D222 and D476 have more conformational flexibility compared to E302 and E245 prior to substrate binding. Interaction similar
to that between D476 and D309, which is expected to assist androgen aromatization, is proposed between E302 and E245. The
inhibition of aromatase activity by 4-hydroxy androstenedione (formestane) is attributed to a critical hydrogen bond formation
between the hydroxy moiety and T310/D309 as well as the large distance from D476. The results corroborate well with earlier
site directed mutagenesis studies. 相似文献