On the Tender X-Ray Flat-Field Spectrograph with a Concave VLS Grating

Journal of Russian Laser Research - We analyze the way of advancing to tender X-rays the short-wavelength bound of the operating range of flat-field grating spectrographs. We design two VLS grating...     

Tandem silylation—desilylation reaction in the synthesis of N-methyl carboxamides

Russian Chemical Bulletin - The N-methylation of primary carboxamides is based on two consecutive reactions. The silylation of the corresponding carboxamides with chloro(chloromethyl)dimethylsilane...     

STRUCTURAL ISOMERS AND VIBRATIONAL SPECTRUM OF TETRAFLUOROSUBSTITUTED ZINC PHTHALOCYANINE

Journal of Structural Chemistry - Structural parameters and relative Gibbs free energies are calculated by density functional theory methods for four tetrafluoro derivatives of zinc(II)...     

Electron Backscattered Diffraction for the Study of Matrices for Immobilization of Actinides Composed of the Murataite-Type Phases

Crystallography Reports - Electron backscattered diffraction (EBSD) has been used to analyze structures of natural minerals and artificial compounds for almost three decades. In recent years, it is...     

The influence of the first integrals and the rolling resistance model on tippe top inversion

Nonlinear Dynamics - In this paper, we analyze the effect which the choice of a friction model has on tippe top inversion in the case where the resulting action of all dissipative forces is...     

The Existence of Zeros of Multivalued Functionals,Coincidence Points,and Fixed Points in $$f$$ -Quasimetric Spaces

Mathematical Notes - The notion of a $$\lambda$$ -generalized-search multivalued functional on an $$f$$ -quasimetric space is introduced. An existence theorem for zeros of such functionals is...     

INFLUENCE OF THE INITIAL ROUGHNESS OF INTERFACES ON THE INSTABILITY DEVELOPMENT AFTER SHOCK-WAVE PASSAGE

Journal of Applied Mechanics and Technical Physics - Turbulent mixing at interfaces of three-layer gas systems after shock-wave passage has been studied. The influence of the initial roughness of...     

A Variational Finite Element Discretization of Compressible Flow

Foundations of Computational Mathematics - We present a finite element variational integrator for compressible flows. The numerical scheme is derived by discretizing, in a structure-preserving way,...     

Effect of External Factors on the Ferromagnetic Resonance Line Width in Exchange-Biased Structures

Physics of the Solid State - The external factors which influence the ferromagnetic resonance (FMR) line width in bilayer (ferromagnet/antiferromagnet) exchange-biased systems are studied. The...     

Topical application of zein-silk sericin nanoparticles loaded with curcumin for improved therapy of dermatitis

Atopic dermatitis is characterized by leukocyte migration into the skin dermis and typically driven by excessive chemokine production at the site of inflammation. Conventional topical formulations such as gels, creams, and ointments are insufficient for this treatment because of low penetration of drug molecules into the targeted skin tissues. Herein, using a simple, green, sustainable strategy, we have developed novel primary zein nanoparticles embedded in curcumin (Cur) and coated with silk sericin (ZHSCs) for the topical delivery of Cur to penetrate into the dermis and exercise anti-dermatitis effects on the lesion with minimal side-effects. Transdermal delivery experiments and porcine skin fluorescence imaging indicated that ZHSCs facilitate the penetration of Cur across the epidermis layer of skin to reach deep-seated sites. Notably, ZHSCs = 1:0.25 (zein-to-silk sericin mass ratios of 1:0.25) markedly elevated the skin permeability and cumulative turnover of Cur transferred, which were provided a greater than a 3.8-fold increase relative to free Cur. The special nanoparticles of ZHS = 1:0.25 possessed the deepest localization depth and experience a transition of the particle structure and core-shell separation after penetrating into the dermis of skin. In a cell model of dermatitis induced by tumor necrosis factor α/interferon γ co-stimulation, compared with free Cur, Cur-loaded ZHS nanoparticles down-regulated the generation of inflammatory cytokines and chemokines in keratinocytes through suppression of the nuclear translocation of NF-κBp65 and hence exerted an anti-dermatitis effect. This strategy may provide new avenues and direction for the demanding issues of valid topical delivery systems.