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41.
42.
Y. Iwasaki K. Kanaya S. Kaya S. Sakai T. Yoshi�� 《The European Physical Journal C - Particles and Fields》2011,71(1):343-346
The nature of QCD phase transition is studied with massless up and down quarks and a light strange quark, using the Wilson formalism for quarks on a lattice with the temporal direction extensionN t=4. We find that the phase transition is of first order for the physical strange quark mass. 相似文献
43.
Sanshiro Komiya Motonori Bundo Takakazu Yamamoto Akio Yamamoto 《Journal of organometallic chemistry》1979,174(3):343-354
Two types of dialkylcobalt(III) complexes containing the 2,2′-bipyridine ligand have been isolated as products of the reactions of tris(2,4-pentanedionato)cobalt(III) (Co(acac)3), 2,2′-bipyridine (bpy), and alkylaluminums in diethyl ether. When high Al/Co ratios (Al/Co > 7) were used, ionic complexes, dialkylbis(2,2′-bipyridine)cobalt(III) tetraalkylaluminates, [CoR2(bpy)2][AlR4] (R = CH3, C2H5) were obtained exclusively. Similar reactions at lower ratios (Al/Co - 1.5–2.0) gave neutral CoR2(acac)(bpy) (R = CH3, C2H5, n-C3H7, i-C3H7). These compounds were characterized by IR and NMR spectroscopy as well as by elemental analysis and chemical reactions. Molecular structural analysis of the cationic dimethylcobalt compound confirmed the cis configuration. Stepwise formation of [CoR2(bpy)2][AlR4] from Co(acac)3 is postulated and the mechanism of the alkylation reaction is discussed. 相似文献
44.
We study a gauge-independent formulation for the effective mass of quark based on the momentum subtraction renormalization condition. To this end a gauge-independent quark propagator is introduced, and with the aid of the resulting mass anomalous dimension, we can discuss the threshold effects in a gauge-independent manner. As an example we find an earlier computation of the top quark mass is modified. We find 2Mt=51±1 GeV. 相似文献
45.
Shin-ichi Furuhata Motonori Okajima Masato Abe Tetsuhisa Goto Hidefumi Makabe 《Tetrahedron》2008,64(33):7695-7703
Total synthesis of pyranicin and its deoxygenated analogues was achieved using Cl2Pd(CH3CN)2 catalyzed diastereoselective cyclization of the allylic ester as the key step. The inhibitory activity of these compounds for mitochondrial NADH-ubiquinone oxidoreductase (complex I) was poorer than those of ordinary mono-THF acetogenins such as annonacin. 相似文献
46.
Kanaya K Tada S Mori B Takahashi R Ikegami S Kurasawa S Okuzaki M Mori Y Innami S 《Journal of AOAC International》2007,90(1):225-237
A preliminary interlaboratory study was conducted to evaluate the validity of the modified AOAC method for determination of total dietary fiber by Tada and Innami, in which the 3-step enzymatic digestion process in AOAC Method 991.43 is modified to a 2-step process without pH adjustment. Total dietary fiber contents in 8 representative foodstuffs were measured using both the original AOAC Method 991.43 and the modified method in 6 research facilities in Japan. Repeatability relative standard deviations, reproducibility relative standard deviations, and Horwitz ratio values from the modified method were equivalent to those from AOAC Method 991.43, except in the rice sample. However, this exceptional case shown in the modified method was entirely dissolved by the addition of alpha-amylase stabilizing agents. The modified method, which shortens the process of enzymatic digestion from 3 to 2 steps and in which only reaction temperature is adjusted under the same pH, was found not only to give accurate values comparable to the original method, but also to substantially reduce the labor required by the laboratory staff in the process of routine analysis. This study revealed that the validity of the modified method was further ensured by adding alpha-amylase stabilizing agents to the reaction system. 相似文献
47.
Shunsuke Okada Motonori Matsusaki Masaki Okumura Takahiro Muraoka 《Molecules (Basel, Switzerland)》2021,26(4)
Oxidative protein folding is a biological process to obtain a native conformation of a protein through disulfide-bond formation between cysteine residues. In a cell, disulfide-catalysts such as protein disulfide isomerase promote the oxidative protein folding. Inspired by the active sites of the disulfide-catalysts, synthetic redox-active thiol compounds have been developed, which have shown significant promotion of the folding processes. In our previous study, coupling effects of a thiol group and guanidyl unit on the folding promotion were reported. Herein, we investigated the influences of a spacer between the thiol group and guanidyl unit. A conjugate between thiol and guanidyl units with a diethylene glycol spacer (GdnDEG-SH) showed lower folding promotion effect compared to the thiol–guanidyl conjugate without the spacer (GdnSH). Lower acidity and a more reductive property of the thiol group of GdnDEG-SH compared to those of GdnSH likely resulted in the reduced efficiency of the folding promotion. Thus, the spacer between the thiol and guanidyl groups is critical for the promotion of oxidative protein folding. 相似文献
48.
Yuya Tanikawa Shingo Kanemura Dai Ito Yuxi Lin Motonori Matsusaki Kimiko Kuroki Hiroshi Yamaguchi Katsumi Maenaka Young-Ho Lee Kenji Inaba Masaki Okumura 《Molecules (Basel, Switzerland)》2021,26(10)
ERp57, a member of the protein disulfide isomerase family, is a ubiquitous disulfide catalyst that functions in the oxidative folding of various clients in the mammalian endoplasmic reticulum (ER). In concert with ER lectin-like chaperones calnexin and calreticulin (CNX/CRT), ERp57 functions in virtually all folding stages from co-translation to post-translation, and thus plays a critical role in maintaining protein homeostasis, with direct implication for pathology. Here, we present mechanisms by which Ca2+ regulates the formation of the ERp57-calnexin complex. Biochemical and isothermal titration calorimetry analyses revealed that ERp57 strongly interacts with CNX via a non-covalent bond in the absence of Ca2+. The ERp57-CNX complex not only promoted the oxidative folding of human leukocyte antigen heavy chains, but also inhibited client aggregation. These results suggest that this complex performs both enzymatic and chaperoning functions under abnormal physiological conditions, such as Ca2+ depletion, to effectively guide proper oxidative protein folding. The findings shed light on the molecular mechanisms underpinning crosstalk between the chaperone network and Ca2+. 相似文献
49.
Motonori Tsuji 《Journal of computer-aided molecular design》2017,31(6):577-585
HX531, which contains a dibenzodiazepine skeleton, is one of the first retinoid X receptor (RXR) antagonists. Functioning via RXR-PPARγ heterodimer, this compound is receiving a lot of attention as a therapeutic drug candidate for diabetic disease controlling differentiation of adipose tissue. However, the active conformation of HX531 for RXRs is not well established. In the present study, quantum mechanics calculations and molecular mechanical docking simulations were carried out to precisely study the docking mode of HX531 with the human RXRα ligand-binding domain, as well as to provide a new approach to drug design using a structure-based perspective. It was suggested that HX531, which has the R configuration for the bent dibenzodiazepine plane together with the equatorial configuration for the N-methyl group attached to the nitrogen atom in the seven-membered diazepine ring, is a typical activation function-2 (AF-2) fixed motif perturbation type antagonist, which destabilizes the formation of AF-2 fixed motifs. On the other hand, the docking simulations supported the experimental result that LG100754 is an RXR homodimer antagonist and an RXR heterodimer agonist. 相似文献
50.
A. Toyoshima K. Ooe S. Miyashita M. Asai M. F. Attallah N. Goto N. S. Gupta H. Haba M. Huang J. Kanaya Y. Kaneya Y. Kasamatsu Y. Kitatsuji Y. Kitayama K. Koga Y. Komori T. Koyama J. V. Kratz H. V. Lerum Y. Oshimi V. Pershina D. Sato T. K. Sato Y. Shigekawa A. Shinohara A. Tanaka K. Tsukada S. Tsuto T. Yokokita A. Yokoyama J. P. Omtvedt Y. Nagame M. Schädel 《Journal of Radioanalytical and Nuclear Chemistry》2015,303(2):1169-1172