全文获取类型
收费全文 | 398篇 |
免费 | 23篇 |
国内免费 | 1篇 |
专业分类
化学 | 335篇 |
晶体学 | 1篇 |
力学 | 2篇 |
数学 | 24篇 |
物理学 | 60篇 |
出版年
2024年 | 2篇 |
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 22篇 |
2020年 | 23篇 |
2019年 | 30篇 |
2018年 | 16篇 |
2017年 | 26篇 |
2016年 | 26篇 |
2015年 | 20篇 |
2014年 | 13篇 |
2013年 | 37篇 |
2012年 | 28篇 |
2011年 | 20篇 |
2010年 | 15篇 |
2009年 | 5篇 |
2008年 | 19篇 |
2007年 | 13篇 |
2006年 | 15篇 |
2005年 | 9篇 |
2004年 | 8篇 |
2003年 | 12篇 |
2002年 | 10篇 |
2001年 | 9篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1993年 | 6篇 |
1991年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1978年 | 1篇 |
1975年 | 1篇 |
1964年 | 1篇 |
1950年 | 1篇 |
1926年 | 1篇 |
1924年 | 2篇 |
1921年 | 2篇 |
排序方式: 共有422条查询结果,搜索用时 21 毫秒
11.
Reaction of 3-hydrazonobutan-2-one oxime with aromatic aldehydes resulted in the formation of 1,2-bis(arylidene)hydrazine commonly referred as azine as an unexpected product, instead of expected product 3-(aryl)methylenehydrazonobutan-2-one oxime, which were subsequently oxidized to corresponding aromatic acids with an ecofriendly oxidizing agent iodobenzene diacetate. Azines and carboxylic acids were characterized by IR and NMR (1H, 13C, HMBC, and HMQC) studies. 相似文献
12.
Waleed A. El‐Said Mona A. Abdel‐Rahman Eman M. Sayed Aboel‐Magd A. Abdel‐Wahab 《Electroanalysis》2019,31(5):829-837
Here, we reported on a one‐step fabrication of magnetite Fe3O4 nanoparticles/indium tin oxide (ITO) electrode based on the direct growing of Fe3O4 nanoparticles on the ITO surface by using a solvothermal process. The modified electrode was used as electrochemical methotrexate (MTX) biosensor with high sensitivity based on cyclic voltammetry and square wave voltammetry techniques. The results demonstrated a linear relationship between the MTX concentration and its oxidation current peak over a wide range from 10?5 to 10?14 mole/L with a limit of detection of 0.4×10?15 M based on the square wave voltammetry (SWV) technique. In addition, Fe3O4/ITO electrode showed a good capability for measuring very low concentrations of MTX drug dissolved in human serum solution. Also, Fe3O4/ITO electrode was used for detecting MTX in blood serum samples collected from patients after their treatment with MTX. The prepared electrode showed the higher sensitivity that higher than the Viva‐E instrument, which opens the door for developing a cheap, simple and higher sensitive MTX sensor. 相似文献
13.
Fatma El-Mariah Mona Hosny Ali Deeb 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):2505-2517
A series of 3-substituted pyridazino[3′,4′:3,4]pyrazolo[5,1-c]-1,2,4-triazens have been synthesized starting from the 3-carboxylic acid derivative 2. The reaction of the acid chloride 3 with amines gave the corresponding anilides 4. The reaction of 2 with ethyl chloroformate and sodium azide in the presence of triethyl amine gave the carbonyl azide 5, which underwent a Curtius rearrangement in boiling ethanol to afford the carbamate 6, which converted to the 3-amino derivative 7 upon alkaline hydrolysis, and the reaction with acid chloride resulted in N-substituted products 9. On other hand, the reaction of the carboxylic acid 2 with POCl3 and thiosemicarbazide afforded 2-amino-1,3,4-thiadiazole derivative 13. The condensation of 13 with aldehydes furnished 14 in a good yield. The products were screened for their antimicrobial activity against six microorganisms. 相似文献
14.
Several N-alkyl/aryl-Se-alkyl/(aryl)selenocarbamates were prepared from various isocyanates and diselenides by reductive cleavage of Se-Se bond with the Zn/AlCl3 system in dry acetonitrile at 80℃. 相似文献
15.
16.
17.
18.
19.
Electroless Ni–P and Ni–P–TiCN composite coatings have been deposited successfully on Al substrates. Scanning electron microscopy (SEM) and energy dispersive X‐ray (EDX) techniques were applied to study the surface morphology and the chemical composition of the deposited films. Moreover, X‐ray diffraction (XRD) proved that Ni–P and Ni–P–TiCN deposits have amorphous structures. The properties of Ni–P–TiCN/Al composite films such as hardness, corrosion resistance and electrocatalytic activity were examined and compared with that of Ni–P/Al film. The results of hardness measurements reveal that the presence of TiCN particles with Ni–P matrix improves its hardness. Additionally, the performance against corrosion was examined using Tafel lines and electrochemical impedance spectroscopy techniques in both of 0.6 M NaCl and a mixture of 0.5 M H2SO4 with 2 ppm HF solutions. The results indicate that the incorporation of high dispersed TiCN particles into Ni–P matrix led to a positive shift of the corrosion potential and an increase in the corrosion resistance for all aluminum substrates after their coating with Ni–P–TiCN. In addition, Ni–P–TiCN/Al electrodes showed a higher electrochemical catalytic activity and stability toward methanol oxidation in 0.5 M NaOH solution compared with that of Ni–P/Al. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
20.
Mona O. Sarhan Somaia S. Abd El-Karim Manal M. Anwar Raghda H. Gouda Wafaa A. Zaghary Mohammed A. Khedr 《Molecules (Basel, Switzerland)》2021,26(8)
Novel 6-bromo-coumarin-ethylidene-hydrazonyl-thiazolyl and 6-bromo-coumarin-thiazolyl-based derivatives were synthesized. A quantitative structure activity relationship (QSAR) model with high predictive power r2 = 0.92, and RMSE = 0.44 predicted five compounds; 2b, 3b, 5a, 9a and 9i to have potential anticancer activities. Compound 2b achieved the best ΔG of –15.34 kcal/mol with an affinity of 40.05 pki. In a molecular dynamic study 2b showed an equilibrium at 0.8 Å after 3.5 ns, while flavopiridol did so at 0.5 Å after the same time (3.5 ns). 2b showed an IC50 of 0.0136 µM, 0.015 µM, and 0.054 µM against MCF-7, A-549, and CHO-K1 cell lines, respectively. The CDK4 enzyme assay revealed the significant CDK4 inhibitory activity of compound 2b with IC50 of 0.036 µM. The selectivity of the newly discovered lead compound 2b toward localization in tumor cells was confirmed by a radioiodination biological assay that was done via electrophilic substitution reaction utilizing the oxidative effect of chloramine-t. 131I-2b showed good in vitro stability up to 4 h. In solid tumor bearing mice, the values of tumor uptake reached a height of 5.97 ± 0.82%ID/g at 60 min p.i. 131I-2b can be considered as a selective radiotheranostic agent for solid tumors with promising anticancer activity. 相似文献