排序方式： 共有42条查询结果，搜索用时 62 毫秒
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Sagawa H Lim J Abe K Fujii Y Higashi Y Kim SK Kurihara Y Maki A Nozaki T Omori T Sakai Y Sugimoto Y Takaiwa Y Terada S Imlay R Kirk P McNeil RR Metcalf W Myung SS Cheng CP Gu P Li J Li YK Mao ZP Xu YT Zhu YC Abashian A Gotow K Hu KP Low EH Mattson ME Piilonen L Sterner KL Lusin S Rosenfeld C Wang AT Wilson S Frautschi M Kagan H Kass R Trahern CG Kim GN Ko W Lander RL Maeshima K Malchow RL Smith JR Sparks K Stuart D Williams MC Kajino F Perticone D Poling R Thomas T Bacala A Park IH Sannes F 《Physical review letters》1989,63(21):2341-2345
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Crawford G Fulton R Jensen T Johnson DR Kagan H Kass R Malchow R Morrow F Whitmore J Wilson P Bortoletto D Brown D Dominick J McIlwain RL Miller DH Modesitt M Ng CR Schaffner SF Shibata EI Shipsey IP Battle M Kroha H Sparks K Thorndike EH Wang C Alam MS Kim IJ Li WC Lou XC Nemati B Romero V Sun CR Wang P Zoeller MM Goldberg M Haupt T Horwitz N Jain V Kennett R Mestayer MD Moneti GC Rozen Y Rubin P Skwarnicki T Stone S Thusalidas M Yao W Zhu G Barnes AV Bartelt J Csorna SE Letson T Alexander J 《Physical review D: Particles and fields》1992,45(3):752-770
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Alam MS Kim IJ Nemati B O'Neill J Severini H Sun CR Zoeller MM Crawford G Daubenmier CM Fulton R Fujino D Gan KK Honscheid K Kagan H Kass R Lee J Malchow R Morrow F Skovpen Y Sung M White C Whitmore J Wilson P Butler F Fu X Kalbfleisch G Lambrecht M Ross WR Skubic P Snow J Wang PL Wood M Bortoletto D Brown DN Fast J McIlwain RL Miao T Miller DH Modesitt M Schaffner SF Shibata EI Shipsey IP Wang PN Battle M Ernst J Kroha H Roberts S Sparks K Thorndike EH Wang CH Dominick J Sanghera S 《Physical review letters》1993,71(9):1311-1315
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Avery P Freyberger A Rodriguez J Stephens R Yelton J Cinabro D Henderson S Kinoshita K Liu T Saulnier M Wilson R Yamamoto H Ong B Selen M Sadoff AJ Ammar R Ball S Baringer P Coppage D Copty N Davis R Hancock N Kelly M Kwak N Lam H Kubota Y Lattery M Nelson JK Patton S Perticone D Poling R Savinov V Schrenk S Wang R Alam MS Kim IJ Nemati B O'Neill JJ Romero V Severini H Sun CR Zoeller MM Crawford G Daubenmier CM Fulton R Fujino D Gan KK Honscheid K Kagan H Kass R Lee J Malchow R Morrow F 《Physical review letters》1993,71(15):2391-2395
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Kinoshita K Pipkin FM Procario M Wilson R Wolinski J Xiao D Zhu Y Ammar R Baringer P Coppage D Davis R Haas P Kelly M Kwak N Lam H Ro S Kubota Y Nelson JK Perticone D Poling R Schrenk S Crawford G Fulton R Jensen T Johnson DR Kagan H Kass R Malchow R Morrow F Whitmore J Wilson P Bortoletto D Brown D Dominick J McIlwain RL Miller DH Modesitt M Ng CR Schaffner SF Shibata EI Shipsey IP Battle M Kroha H Sparks K Thorndike EH Wang C Alam MS Kim IJ Li WC Romero V Sun CR Wang P Zoeller MM Goldberg M 《Physical review D: Particles and fields》1991,43(9):2836-2842
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Blocking Deprotonation with Retention of Aromaticity in a Plant ent‐Copalyl Diphosphate Synthase Leads to Product Rearrangement 
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下载免费PDF全文 Kevin C. Potter Dr. Jiachen Zi Dr. Young J. Hong Samuel Schulte Brandi Malchow Prof. Dr. Dean J. Tantillo Prof. Dr. Reuben J. Peters 《Angewandte Chemie (International ed. in English)》2016,55(2):634-638
Substitution of a histidine, comprising part of the catalytic base group in the ent‐copalyl diphosphate synthases found in all seed plants for gibberellin phytohormone metabolism, by a larger aromatic residue leads to rearrangements. Through a series of 1,2‐hydride and methyl shifts of the initially formed bicycle predominant formation of (?)‐kolavenyl diphosphate is observed. Further mutational analysis and quantum chemical calculations provide mechanistic insight into the basis for this profound effect on product outcome. 相似文献
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Yang JJ Yang J Wei L Zurkiya O Yang W Li S Zou J Zhou Y Maniccia AL Mao H Zhao F Malchow R Zhao S Johnson J Hu X Krogstad E Liu ZR 《Journal of the American Chemical Society》2008,130(29):9260-9267
We describe the rational design of a novel class of magnetic resonance imaging (MRI) contrast agents with engineered proteins (CAi.CD2, i = 1, 2,..., 9) chelated with gadolinium. The design of protein-based contrast agents involves creating high-coordination Gd(3+) binding sites in a stable host protein using amino acid residues and water molecules as metal coordinating ligands. Designed proteins show strong selectivity for Gd(3+) over physiological metal ions such as Ca(2+), Zn(2+), and Mg(2+). These agents exhibit a 20-fold increase in longitudinal and transverse relaxation rate values over the conventional small-molecule contrast agents, e.g., Gd-DTPA (diethylene triamine pentaacetic acid), used clinically. Furthermore, they exhibit much stronger contrast enhancement and much longer blood retention time than Gd-DTPA in mice. With good biocompatibility and potential functionalities, these protein contrast agents may be used as molecular imaging probes to target disease markers, thereby extending applications of MRI. 相似文献
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Park IH Schnetzer S Green J Sakamoto S Sannes F Stone R Trentalange S Vinson J Bacala A Imlay R Kirk P Lim J McNeil RR Metcalf W Cheng CP Li J Li YK Mao ZP Xu YT Zhu YC Abashian A Gotow K Low EH Mattson ME Naito F Piilonen L Sterner KL Lusin S Rosenfeld C Wang AT Wilson S Frautschi M Kagan H Kass R Trahern CG Ko W Lander RL Maeshima K Malchow RL Smith JR Sparks K Williams MC Abe K Fujii Y Higashi Y Kim SK Kurihara Y Maki A Nozaki T Omori T Sagawa H Sakai Y Sugimoto Y Takaiwa Y Terada S 《Physical review letters》1989,62(15):1713-1716
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Li YK Li J Cheng CP Gu P Ye MH Zhu YC Imlay R Kirk P Lim J McNeil RR Metcalf W Myung SS Abashian A Gotow K Hu KP Low EH Mattson ME Piilonen L Sterner KL Lusin S Rosenfeld C Wang AT Wilson S Frautschi M Kagan H Kass R Trahern CG Breedon RE Kim GN Ko W Lander RL Maeshima K Malchow RL Smith JR Stuart D Abe K Fujii Y Higashi Y Kim SK Kurihara Y Maki A Nozaki T Omori T Sagawa H Sakai Y Sugimoto Y Takaiwa Y Terada S Walker RC Kajino F Perticone D Poling R Thomas T Ishi Y Miyano K Miyata H Sasaki T 《Physical review D: Particles and fields》1990,41(9):2675-2688