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961.
Rich and complex Raman scattering and Raman optical activity (ROA) spectra have been measured monitoring the pH induced alpha-helix-to-disordered conformational transition in poly(L-glutamic acid). Two-dimensional (2D) correlation techniques have been applied to facilitate a comprehensive analysis of these two complementary spectral sets. Synchronous contour plots have identified band assignments of alpha-helical and disordered conformations, and have revealed bands characteristic of changes in the protonation state of the polypeptide. Asynchronous plots, on the other hand, have probed the relative sequential orders of intensity changes indicating a decrease in intensity of alpha-helical bands in the backbone skeletal stretch region, followed by a subsequent decrease in intensity in the extended amide III and amide I regions, underlying the appearance of disordered structure, including poly(L-proline) II (PPII) helix. The application of a 2D correlation 'moving' window has also disclosed two distinct phases during helix unfolding in the alpha-helix-to-disordered transition, occurring at approximately pH 4.9 and approximately pH 5.2, possibly a result of the difference in helical stability between the end and central regions of the alpha-helix. This paper demonstrates the potential value of combining 2D Raman, 2D ROA and moving window correlation techniques for the detailed investigation of complex and subtle changes of secondary structure during the unfolding mechanisms of polypeptides and proteins. 相似文献
962.
Local-edge-connectivity in digraphs and oriented graphs 总被引:2,自引:0,他引:2
Lutz Volkmann 《Discrete Mathematics》2007,307(24):3207-3212
A digraph without any cycle of length two is called an oriented graph. The local-edge-connectivityλ(u,v) of two vertices u and v in a digraph or graph D is the maximum number of edge-disjoint u-v paths in D, and the edge-connectivity of D is defined as . Clearly, λ(u,v)?min{d+(u),d-(v)} for all pairs u and v of vertices in D. Let δ(D) be the minimum degree of D. We call a graph or digraph D maximally edge-connected when λ(D)=δ(D) and maximally local-edge-connected when
λ(u,v)=min{d+(u),d-(v)} 相似文献
963.
Bis-indolylquinones represent a class of fungal natural products that display antiretroviral, antidiabetes, or cytotoxic bioactivities. Recent advances in Aspergillus genomic mining efforts have led to the discovery of the tdiA-E-gene cluster, which is the first genetic locus dedicated to bis-indolylquinone biosynthesis. We have now genetically and biochemically characterized the enzymes TdiA (bis-indolylquinone synthetase) and TdiD (L-tryptophan:phenylpyruvate aminotransferase), which, together, confer biosynthetic abilities for didemethylasterriquinone D to Aspergillus nidulans. This compound is the universal intermediate for all bis-indolylquinones. In this biochemical study of a bis-indolylquinone synthetase and a fungal natural product transaminase, we present a one-pot chemoenzymatic protocol to generate didemethylasterriquinone D in vitro. As TdiA resembles a nonribosomal peptide synthetase, yet catalyzes carbon-carbon-bond formation, we discuss the implications for peptide synthetase chemistry. 相似文献
964.
Müller C Wasserberg D Weemers JJ Pidko EA Hoffmann S Lutz M Spek AL Meskers SC Janssen RA van Santen RA Vogt D 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(16):4548-4559
A series of donor-functionalized pyrylium salts have been prepared by classical condensation reactions which were further converted into the corresponding thienyl- and pyridyl-substituted polydentate lambda(3)-phosphinines by reaction with P(SiMe(3))(3). Further chemical modification of these phosphorus heterocycles with Hg(OAc)(2) in the presence of methanol resulted in the formation of lambda(5)-phosphinines. The photophysical properties of a selected series of thienyl- and pyridyl-functionalized pyrylium salts, lambda(3)- and lambda(5)-phosphinines, were investigated and the results compared and supported by theoretical calculations on the DFT level. Significant fluorescence was observed for the pyrylium salts and lambda(5)-phosphinines. In contrast, the heteroaromatic substituted lambda(3)-phosphinines show very little emission which is consistent with the low oscillator strength predicted by DFT calculations for this pi-->pi* transition. Furthermore, all three classes of compounds show readily observable phosphorescence in solution, which was determined by time-gated detection at low temperature. 相似文献
965.
Prager L Dierdorf A Liebe H Naumov S Stojanović S Heller R Wennrich L Buchmeiser MR 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(30):8522-8529
The photochemical conversion of 200-500 nm layers of perhydropolysilazane --(SiH2-NH)n-- (PHPS) in the presence of oxygen into an SiOx network was studied. Different UV sources in the wavelength range of 160-240 nm, that is, 172 nm Xe2* and 222 nm KrCl* excimer, and 185 nm Hg low-pressure (HgLP) lamps were used for these purposes. The role of both ozone and O(1D) as well as of catalytic amounts of tertiary amines in the degradation process of PHPS and the formation of SiOx were studied. In this context, the kinetics of the entire reaction were elucidated and allowed both a continuous and discontinuous process to be established for the production of fully transparent, flexible barrier coatings. Barrier improvement factors (BIFs) of 400 were achieved with one single layer on 23 microm poly(ethyleneterephthalate) (PET), which translated into oxygen transmission rates (OTRs) of 0.20 cm3 m(-2) day(-1) bar(-1). Double layers prepared by this technique allowed the realization of OTRs of or=800. 相似文献
966.
Foltz C Stecker B Marconi G Bellemin-Laponnaz S Wadepohl H Gade LH 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(35):9912-9923
The underlying conceptual differences in exploiting two- and threefold rotational symmetry in the design of chiral ligands for asymmetric catalysis have been addressed in a comparative study of the catalytic performance of bisoxazoline (BOX) and tris(oxazolinyl)ethanes (trisox) containing copper(II) Lewis acid catalysts. The differences become apparent in constructing new catalysts by systematically "deforming" the stereodirecting ligand by inverting chiral centres or replacing chiral by achiral oxazolines. The catalytic alpha-amination of ethyl 2-methylacetoacetate with dibenzyl azodicaboxylate, which occurs with high enantioselectivity for both Ph(2)-BOX and Ph(3)-trisox copper catalysts, has been employed as the test reaction. In the trisox-copper complex [Cu(II)(iPr(3)-trisox)(kappa(2)-O,O'-MeCOCHCOOEt)](+)[BF(4)](-) (1), which was characterised by X-ray diffraction, two of the oxazoline groups are coordinated to the central copper atom, whilst the third oxazoline unit is dangling with the N-donor pointing away from the metal centre. A similar arrangement is found for the stereochemically "mixed" C(1)-trisox complex [Cu(II){(Ph(3)-trisox(R,S,S)}(kappa(2)-O,O'-MeCOCHCOOEt)(H(2)O)](+)[ClO(4)](-) (2), in which the phenyl substituents adopt a first coordination sphere meso arrangement. The almost identical selectivity of the Ph(3)-trisox(R,R,R)- and Ph(2)-BOX(R,R)-derived catalysts is as expected from the proposed model of the active catalyst based on a partially decoordinated podand. The behaviour of the "desymmetrised" trisox-Cu catalysts may be rationalised in terms of a general steady-state kinetic model for the three possible active bisoxazoline-copper species, which are expected to be in rapid exchange with each other in solution. This applies to both the trisox derivatives with stereochemically inverted and achiral oxazoline rings. The study underscores previous observations of superior performance of the catalysts bearing C(3)-chiral stereodirecting ligands as compared to systems of lower symmetry. 相似文献
967.
Hübschle CB Scheins S Weber M Luger P Wagner A Koritsánszky T Troyanov SI Boltalina OV Goldt IV 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(7):1910-1920
The experimental charge densities of the halogenated C(60) fullerenes C(60)F(18) and C(60)Cl(30) were determined from high-resolution X-ray data sets measured with conventional Mo(Kalpha) radiation at 20 K for C(60)Cl(30) and with synchrotron radiation at 92 K for the fluorine compound. Bond topological and atomic properties were analyzed by using Bader's AIM theory. For the different C--C bonds, which vary in lengths between 1.35 and 1.70 A bond orders n between n=2 and significantly below n=1 were calculated from the bond topological properties at the bond critical points (BCP's). The low bond orders are seen for 5/6 bonds with each contributing carbon carrying a halogen atom. By integration over Bader's zero flux basins in the electron density gradient vector field atomic properties were also obtained. In contrast to free C(60), in which all carbon atoms have a uniform volume of 11 A(3) and zero charge, atomic volumes vary roughly between 5 and 10 A(3) in the halogenated compounds. Almost zero atomic charges are also found in the Cl derivative but a charge separation up to +/-0.8 e exists between C and F in C(60)F(18) due to the higher fluorine electronegativity, which is also seen in the electrostatic potential for which the electronegativity difference between carbon and fluorine, and the addition to one hemisphere of the fullerene cage leads to a strong potential gradient along the C(60)F(18) molecule. From the summation over all atomic volumes it follows that the halogen addition does not only lead to a dramatic distortion of the C(60) cage but also to a significant shrinkage of its volume. 相似文献
968.
Gagliardo M Amijs CH Lutz M Spek AL Havenith RW Hartl F van Klink GP van Koten G 《Inorganic chemistry》2007,46(26):11133-11144
The dinuclear complex [(tpy)RuII(PCP-PCP)RuII(tpy)]Cl2 (bridging PCP-PCP = 3,3',5,5'-tetrakis(diphenylphosphinomethyl)biphenyl, [C6H2(CH2PPh2)2-3,5]22-) was prepared via a transcyclometalation reaction of the bis-pincer ligand [PC(H)P-PC(H)P] and the Ru(II) precursor [Ru(NCN)(tpy)]Cl (NCN = [C6H3(CH2NMe2)2-2,6]-) followed by a reaction with 2,2':6',2' '-terpyridine (tpy). Electrochemical and spectroscopic properties of [(tpy)RuII(PCP-PCP)RuII(tpy)]Cl2 are compared with those of the closely related [(tpy)RuII(NCN-NCN)RuII(tpy)](PF6)2 (NCN-NCN = [C6H2(CH2NMe2)2-3,5]22-) obtained by two-electron reduction of [(tpy)RuIII(NCN-NCN)RuIII(tpy)](PF6)4. The molecular structure of the latter complex has been determined by single-crystal X-ray structure determination. One-electron reduction of [(tpy)RuIII(NCN-NCN)RuIII(tpy)](PF6)4 and one-electron oxidation of [(tpy)RuII(PCP-PCP)RuII(tpy)]Cl2 yielded the mixed-valence species [(tpy)RuIII(NCN-NCN)RuII(tpy)]3+ and [(tpy)RuIII(PCP-PCP)RuII(tpy)]3+, respectively. The comproportionation equilibrium constants Kc (900 and 748 for [(tpy)RuIII(NCN-NCN)RuIII(tpy)]4+ and [(tpy)RuII(PCP-PCP)RuII(tpy)]2+, respectively) determined from cyclic voltammetric data reveal comparable stability of the [RuIII-RuII] state of both complexes. Spectroelectrochemical measurements and near-infrared (NIR) spectroscopy were employed to further characterize the different redox states with special focus on the mixed-valence species and their NIR bands. Analysis of these bands in the framework of Hush theory indicates that the mixed-valence complexes [(tpy)RuIII(PCP-PCP)RuII(tpy)]3+ and [(tpy)RuIII(NCN-NCN)RuII(tpy)]3+ belong to strongly coupled borderline Class II/Class III and intrinsically coupled Class III systems, respectively. Preliminary DFT calculations suggest that extensive delocalization of the spin density over the metal centers and the bridging ligand exists. TD-DFT calculations then suggested a substantial MLCT character of the NIR electronic transitions. The results obtained in this study point to a decreased metal-metal electronic interaction accommodated by the double-cyclometalated bis-pincer bridge when strong sigma-donor NMe2 groups are replaced by weak sigma-donor, pi-acceptor PPh2 groups. 相似文献
969.
The 1H NMR spectra of a series of mono- and dinuclear pyridine complexes [FeL1(R1/R2)(py)2] and [Fe2L2(R1/R2)(py)4] have been investigated in a mixed toluene-d8/pyridine-d5 solution. The equatorial tetradentade Schiff base like ligands L1(R1/R2) and L2(R1/R2) with a N2O22- coordination sphere for each metal center have been obtained by condensation of a substituted malonodialdehyde (R1/R2 are Me/COOEt, Me/COMe, or OEt/COOEt) with o-phenylenediamine (L1(R1/R2)) or 1,2,4,5-tetraaminobenzene (L2(R1/R2)). The 1H NMR resonances were assigned by comparison of differently substituted complexes in combination with a line-width comparison. The 1H NMR shifts from 188 to 358 K show a strong influence of the spin state of the iron center. The behavior of the pure high-spin iron(II) complexes is close to ideal Curie behavior. Analysis of the resonance shifts of the spin-transition complexes can be used for determining the high-spin mole fraction of the complex in solution at different temperatures. Magnetic susceptibility measurements in solution using the Evans method were made for all six complexes. Significant differences between the spin-transition behavior of the complexes in solution of those in the solid state were found. However, the plots of microeff as a function of temperature obtained using the Evans method and those obtained by interpretation of the NMR shifts were virtually identical. The isotropic shifts of protons in the complexes proved to be suitable tools for following a spin transition in solution. Comparison of the microeff plots of the mono- and dinuclear complexes in solution reveals slight differences between the steepness of the curves that may be attributable to cooperative interactions between the metal centers in the case of the dinuclear complexes. 相似文献
970.
The coarse graining method to be advocated in this paper consists of two main steps. First, the propagation of an ensemble of molecular states is described as a Markov chain by a transition probability matrix in a finite state space. Second, we obtain metastable conformations by an aggregation of variables via Robust Perron Cluster Analysis (PCCA+). Up to now, it has been an open question as to how this coarse graining in space can be transformed to a coarse graining of the Markov chain while preserving the essential dynamic information. In this article, we construct a coarse matrix that is the correct propagator in the space of conformations. This coarse graining procedure carries over to rate matrices and allows to extract transition rates between molecular conformations. This approach is based on the fact that PCCA+ computes molecular conformations as linear combinations of the dominant eigenvectors of the transition matrix. 相似文献