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991.
ABSTRACTHerein, we develop a switchable peptide-equipped protein/cucurbit[7]uril (CB[7]) supramolecular assembly as novel targeted drug vector. Specifically, bovine serum albumin (BSA) is used to interact with CB[7], serving as the core of drug vector. Then, a peptide shield layer is formed on the surface of BSA/CB[7], yielding peptide-equipped supramolecular assembly (Pep@BSA@CB[7]). The equipped peptide shield layer is composed of switchable peptide probes consisting of a polycationic cell-penetrating peptide (CPP) motif, a polyanionic motif and a linking motif, and therefore provides a variety of desirable properties. First, the CPP motif displays excellent cell penetration ability and can facilitate internalisation of the drug vector. Secondly, the polyanionic motif performs intramolecular electrostatic interaction with CPP motif and thereby can reduce non-targeted delivery towards normal cells. Thirdly, the linking motif can be specifically cleaved by matrix metalloproteinases 2 that is up-regulated in tumour microenvironment, thus enabling precise cancer-targeting. As a consequent, Pep@BSA@CB[7] can serve as a promising drug vector that exhibits superior targeting ability and high uptake efficiency towards cancer cells, which may be of great potential in cancer-targeted treatment. 相似文献
992.
993.
Yi Yuan Zong-Lin Jiang Jia-Ming Yan Ge Gao Albert S. C. Chan Ru-Gang Xie 《合成通讯》2013,43(24):4555-4561
Two new macrobicyclic imidazolium and benzimidazolium phanes were synthesized by direct quaternization of the corresponding tripodal azacycles with tribromide under high dilution condition in excellent yields. The cyclophanes were identified by 1H-NMR, 13C-NMR, FAB-MS, IR, elemental analysis and X-ray diffraction analysis. 相似文献
994.
Qian Yan 《Numerical Functional Analysis & Optimization》2013,34(13):1351-1373
AbstractThe aim of this paper is to introduce the generalized viscosity implicit rules of one asymptotically nonexpansive mapping in the intermediate sense in Hilbert spaces. We obtain some strong convergence theorems under certain assumptions imposed on the parameters. We also give a numerical example to support our main results. The results obtained in this paper improve and extend many recent ones in this culture. 相似文献
995.
A theoretical scheme for preserving the entanglement in a two-qubit-spin coupled system in the presence of Dzyaloshinskii–Moriya (DM) anisotropic antisymmetric interaction is proposed. On the basis of a sequence of operations performed periodically on the system, the scheme can preserve the entanglement of the system starting from any initial state with any desired high precision for any desired long duration. 相似文献
996.
采用电感耦合等离子体发射原子发射光谱法(ICP-AES)测定了电解镍中锰、磷、钴、铁、铜、镁、铝、锌、镉、硅和锡等11种元素的含量,对仪器各项参数进行优化,采用基体匹配办法克服基体干扰,通过选择合适的分析谱线和背景校正消除共存元素间干扰。方法应用于实际样品分析,11种元素的回收率为92.0%—107.0%,相对标准偏差0.3%—5.1%,测定结果与标准方法的测定值相符。 相似文献
997.
A new method for the synthesis of novel C‐substituted piperazine derivatives bearing aryl substituents on 2,6‐C positions has been developed by one‐pot three‐component sequential reaction of α‐bromoarylethanones with ethanolamine in the presence of formic acid. The structure of the novel compounds was established by nuclear magnetic resonance (NMR), mass spectrometry (MS), and elemental analysis. In addition, the crystal structure of 4e was determined by single X‐ray crystallography and a possible reaction mechanism was proposed. 相似文献
998.
Qingxiang Zhou Zhenwen Zheng Junping Xiao Huili Fan Xiuyi Yan 《Analytical and bioanalytical chemistry》2016,408(19):5211-5220
999.
Yan Sun Nianchen Zhou Wei Zhang Yaowen Li Zhenping Cheng Jian Zhu Zhengbiao Zhang Xiulin Zhu 《Journal of polymer science. Part A, Polymer chemistry》2012,50(18):3788-3796
Two novel and well‐defined polymers, poly[6‐(5‐(diphenylamino)‐2‐((4‐methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate] (PDMMA) and poly[6‐(4‐((3‐ethynylphenyl)diazenyl) phenoxy)hexyl methacrylate] (PDPMMA), which bear triphenylamine (TPA) incorporated to azobenzene either directly (PDMMA) or with an interval (PDPMMA) as pendant groups were successfully prepared via reversible addition‐fragmentation chain transfer polymerization technique. The electrochemical behaviors of PDPMMA and PDMMA were investigated by cyclic voltammograms (CV) measurement. The hole mobilities of the polymer films were determined by fitting the J‐V (current‐voltage) curve into the space‐charge‐limited current method. The influence of photoisomerization of the azobenzene moiety on the behaviors of fluorescence emission, CV and hole mobilities of these two polymers were studied. The fluorescent emission intensities of these two polymers in CH2Cl2 were increased by about 100 times after UV irradiation. The oxidation peak currents (IOX) of the PDMMA and PDPMMA in CH2Cl2 were increased after UV irradiation. The photoisomerization of the azobenzene moiety in PDMMA had significant effect on the electrochemical behavior, compared with that in PDPMMA. The changes of the hole mobility before and after UV irradiation were very small for both polymers. The HOMO energies (EHOMO, HOMO: the highest occupied molecular orbital) of side chain moieties of TPA incorporated with cis‐isomer and trans‐isomer of azobenzene in PDMMA and PDPMMA were obtained by theoretical calculation, which are basically consistent with the experimental results. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 相似文献
1000.