全文获取类型
收费全文 | 258794篇 |
免费 | 5916篇 |
国内免费 | 3941篇 |
专业分类
化学 | 136415篇 |
晶体学 | 3512篇 |
力学 | 12125篇 |
综合类 | 235篇 |
数学 | 28988篇 |
物理学 | 87376篇 |
出版年
2021年 | 2320篇 |
2020年 | 2685篇 |
2019年 | 2963篇 |
2018年 | 3501篇 |
2017年 | 3398篇 |
2016年 | 5023篇 |
2015年 | 3521篇 |
2014年 | 5296篇 |
2013年 | 11949篇 |
2012年 | 9752篇 |
2011年 | 11829篇 |
2010年 | 8405篇 |
2009年 | 8319篇 |
2008年 | 10577篇 |
2007年 | 10449篇 |
2006年 | 9805篇 |
2005年 | 8841篇 |
2004年 | 7996篇 |
2003年 | 6978篇 |
2002年 | 6913篇 |
2001年 | 7798篇 |
2000年 | 5969篇 |
1999年 | 4798篇 |
1998年 | 4060篇 |
1997年 | 3907篇 |
1996年 | 3757篇 |
1995年 | 3387篇 |
1994年 | 3314篇 |
1993年 | 3372篇 |
1992年 | 3468篇 |
1991年 | 3500篇 |
1990年 | 3209篇 |
1989年 | 3122篇 |
1988年 | 3131篇 |
1987年 | 3002篇 |
1986年 | 2852篇 |
1985年 | 3880篇 |
1984年 | 4026篇 |
1983年 | 3173篇 |
1982年 | 3403篇 |
1981年 | 3325篇 |
1980年 | 3216篇 |
1979年 | 3348篇 |
1978年 | 3421篇 |
1977年 | 3349篇 |
1976年 | 3459篇 |
1975年 | 3134篇 |
1974年 | 3156篇 |
1973年 | 3208篇 |
1972年 | 2232篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
31.
Dr. Chen-Ming Lin Maritess Arancillo Jonathan Whisenant Prof. Kevin Burgess 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(24):9484-9488
Secondary structures tend to be recognizable because they have repeating structural motifs, but mimicry of these does not have to follow such well-defined patterns. Bioinformatics studies to match side-chain orientations of a novel hydantoin triazole chemotype ( 1 ) to protein-protein interfaces revealed it tends to align well across parallel and antiparallel sheets, like rungs on a ladder. One set of these overlays was observed for the protein-protein interaction uPA⋅uPAR. Consequently, chemotype 1 was made with appropriate side-chains to mimic uPA at this interface. Biophysical assays indicate these compounds did in fact bind uPAR, and elicit cellular responses that affected invasion, migration, and wound healing. 相似文献
32.
Komarova E. G. Sedelnikova M. B. Kazantseva E. A. Uvarkin P. V. Sharkeev Yu. P. 《Russian Physics Journal》2020,63(7):1249-1256
Russian Physics Journal - A relationship between the structural-morphological and physical-mechanical properties of macro-porous calcium phosphate (CaP) coatings on the surface of titanium implants... 相似文献
33.
Complex Study of the Spearhead Superficial Crust from Burial Mound no. 1 near Novosvobodnaya Village
Loboda A. Yu. Kolobylina N. N. Veligzhanin A. A. Zubavitchus Y. V. Tereshchenko E. Yu. Shishlina N. I. Yatsishina E. B. Kashkarov P. K. 《Crystallography Reports》2018,63(2):295-301
A complex study of a spearhead dated back to IV mill. BC from burial mound no. 1 near Novosvobodnaya village (collection of the State Historical Museum) and, in particular, the material of spearhead superficial crust has been performed. The elemental and phase composition of the metal of spearhead and the superficial crust on its surface have been determined by scanning electron microscopy, jointly with energydispersive X-ray microanalysis and X-ray phase analysis. A comparative analysis of the results of studying the spearhead superficial crust and similar crusts on other artifacts from the mounds near Novosvobodnaya village suggest natural origin of the crust on copper?arsenic artifacts.
相似文献34.
35.
Yanxia Xu Yanbing Lv Ruili Wu Huaibin Shen Huawei Yang Han Zhang Jinjie Li Lin Song Li 《Particle & Particle Systems Characterization》2020,37(3):1900441
Indium phosphide (InP) quantum dots (QDs) are ideal substitutes for widely used cadmium-based QDs and have great application prospects in biological fields due to their environmentally benign properties and human safety. However, the synthesis of InP core/shell QDs with biocompatibility, high quantum yield (QY), uniform particle size, and high stability is still a challenging subject. Herein, high quality (QY up to 72%) thick shell InP/GaP/ZnS core/shell QDs (12.8 ± 1.4 nm) are synthesized using multiple injections of shell precursor and extension of shell growth time, with GaP serving as the intermediate layer and 1-octanethiol acting as the new S source. The thick shell InP/GaP/ZnS core/shell QDs still keep high QY and photostability after transfer into water. InP/GaP/ZnS core/shell QDs as fluorescence labels to establish QD-based fluorescence-linked immunosorbent assay (QD-FLISA) for quantitative detection of C-reactive protein (CRP), and a calibration curve is established between fluorescence intensity and CRP concentrations (range: 1–800 ng mL−1, correlation coefficient: R2 = 0.9992). The limit of detection is 2.9 ng mL−1, which increases twofold compared to previously reported cadmium-free QD-based immunoassays. Thus, InP/GaP/ZnS core/shell QDs as a great promise fluorescence labeling material, provide a new route for cadmium-free sensitive and specific immunoassays in biomedical fields. 相似文献
36.
37.
Dr. Sabin Llona‐Minguez Dr. Matthieu Desroses Artin Ghassemian Dr. Sylvain A. Jacques Dr. Lars Eriksson Rebecka Isacksson Tobias Koolmeister Dr. Pål Stenmark Dr. Martin Scobie Prof. Thomas Helleday 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(20):7394-7398
A two‐step synthesis of structurally diverse pyrrole‐containing bicyclic systems is reported. ortho‐Nitro‐haloarenes coupled with vinylic N‐methyliminodiacetic acid (MIDA) boronates generate ortho‐vinyl‐nitroarenes, which undergo a “metal‐free” nitrene insertion, resulting in a new pyrrole ring. This novel synthetic approach has a wide substrate tolerance and it is applicable in the preparation of more complex “drug‐like” molecules. Interestingly, an ortho‐nitro‐allylarene derivative furnished a cyclic β‐aminophosphonate motif. 相似文献
38.
39.
40.
Nano palladium supported on high‐surface‐area metal–organic framework MIL‐101: an efficient catalyst for Sonogashira coupling of aryl and heteroaryl bromides with alkynes 下载免费PDF全文
Manne Annapurna T. Parsharamulu P. Vishnuvardhan Reddy M. Suresh Pravin R. Likhar Mannepalli Lakshmi Kantam 《应用有机金属化学》2015,29(4):234-239
Palladium nanoparticle‐incorporated metal–organic framework MIL‐101 (Pd/MIL‐101) was successfully synthesized and characterized using X‐ray diffraction, nitrogen physisorption, X‐ray photoelectron, UV–visible and infrared spectroscopies, and transmission electron microscopy. The characterization techniques confirmed high porosity and high surface area of MIL‐101 and high stability of nano‐size palladium particles. Pd/MIL‐101 nanocomposite was investigated for the Sonogashira cross‐coupling reaction of aryl and heteroaryl bromides with various alkynes under copper‐free conditions. The reusability of the catalyst was tested for up to four cycles without any significant loss in catalytic activity. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献