全文获取类型
收费全文 | 879篇 |
免费 | 72篇 |
国内免费 | 8篇 |
专业分类
化学 | 645篇 |
晶体学 | 8篇 |
力学 | 28篇 |
数学 | 97篇 |
物理学 | 181篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 33篇 |
2020年 | 17篇 |
2019年 | 23篇 |
2018年 | 18篇 |
2017年 | 14篇 |
2016年 | 35篇 |
2015年 | 28篇 |
2014年 | 39篇 |
2013年 | 56篇 |
2012年 | 68篇 |
2011年 | 80篇 |
2010年 | 64篇 |
2009年 | 50篇 |
2008年 | 63篇 |
2007年 | 49篇 |
2006年 | 31篇 |
2005年 | 39篇 |
2004年 | 34篇 |
2003年 | 31篇 |
2002年 | 37篇 |
2001年 | 20篇 |
2000年 | 14篇 |
1999年 | 9篇 |
1998年 | 10篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 7篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1934年 | 1篇 |
排序方式: 共有959条查询结果,搜索用时 501 毫秒
101.
M. V. Pergal J. V. Džunuzović M. Kićanović V. Vodnik M. M. Pergal S. Jovanović 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2011,85(13):2251-2256
Novel polyurethanes (PUs) were synthesized using hydroxy-terminated hyperbranched polyester (BH-20) and 4,4′-methylenediphenyl
diisocyanate (MDI) as hard segments and hydroxy-terminated ethylene oxide-poly(dimethylsiloxane)-ethylene oxide triblock copolymer
(PDMS-EO) as soft segment, with soft segment content ranging from 30 to 60 wt %. The PUs were synthesized by two-step solution
polymerization method. The influence of the soft segment content on the structure, swelling behavior and thermal properties
of PUs was investigated. According to the results obtained by swelling measurements, the increase of the hard segment content
resulted in the increase of the crosslinking density of synthesized samples. DSC results showed that the glass transition
temperatures increase from 36 to 65°C with increasing hard segment content. It was demonstrated using thermogravimetric analysis
(TGA) that thermal stability of investigated PUs increases with increase of the soft PDMS-EO content. This was concluded from
the temperatures corresponding to the 10 wt % loss, which represents the beginning of thermal degradation of samples. 相似文献
102.
Park KD Kim D Reamtong O Eyers C Gaskell SJ Liu R Kohn H 《Journal of the American Chemical Society》2011,133(29):11320-11330
We have advanced a useful strategy to elucidate binding partners of ligands (drugs) with modest binding affinity. Key to this strategy is attaching to the ligand an affinity bait (AB) and a chemical reporter (CR) group, where the AB irreversibly attaches the ligand to the receptor upon binding and the CR group is employed for receptor detection and isolation. We have tested this AB&CR strategy using lacosamide ((R)-1), a low-molecular-weight antiepileptic drug. We demonstrate that using a (R)-lacosamide AB&CR agent ((R)-2) 14-3-3 ζ in rodent brain soluble lysates is preferentially adducted, adduction is stereospecific with respect to the AB&CR agent, and adduction depends upon the presence of endogenous levels of the small molecule metabolite xanthine. Substitution of lacosamide AB agent ((R)-5) for (R)-2 led to the identification of the 14-3-3 ζ adduction site (K120) by mass spectrometry. Competition experiments using increasing amounts of (R)-1 in the presence of (R)-2 demonstrated that (R)-1 binds at or near the (R)-2 modification site on 14-3-3 ζ. Structure-activity studies of xanthine derivatives provided information concerning the likely binding interaction between this metabolite and recombinant 14-3-3 ζ. Documentation of the 14-3-3 ζ-xanthine interaction was obtained with isothermal calorimetry using xanthine and the xanthine analogue 1,7-dimethylxanthine. 相似文献
103.
Synthesis of the proposed structure of lytophilippine A was accomplished employing SmI(2)-mediated 5-exo cyclization of an aldehydo β-alkoxyvinyl sulfoxide and ring-closing metathesis reaction. 相似文献
104.
Antioxidant and antityrosinase activities of various extracts from the fruiting bodies of Lentinus lepideus 总被引:1,自引:0,他引:1
Yoon KN Alam N Lee KR Shin PG Cheong JC Yoo YB Lee TS 《Molecules (Basel, Switzerland)》2011,16(3):2334-2347
Lentinus lepideus is an edible mushroom currently available in Korea. The acetone, methanol and hot water extracts were prepared and assayed for their antioxidant and antityrosinase inhibitory activities. The hot water extract showed the strongest β-carotene-linoleic acid inhibition compared to the other extracts. At 8 mg/mL, the methanolic extract showed a high reducing power of 1.21. The acetone and methanol extracts were more effective in scavenging DPPH radicals than the hot water extract. The strongest chelating effect was obtained from the methanolic extract. Xanthine oxidase and tyrosinase inhibitory activities of the acetonic, methanol and hot water extracts increased with increasing concentration. Gallic acid, chlorogenic acid, vanillin, naringin, naringenin, formononetin, and biochanin-A were detected in the acetonitrile and hydrochloric acid (5:1) solvent extract. This study suggests that fruiting bodies of L. lepideus can potentially be used as a readily accessible source of natural antioxidants. 相似文献
105.
Kim KC Kulkarni AD Johnson JK Sholl DS 《Physical chemistry chemical physics : PCCP》2011,13(48):21520-21529
First principles calculations have played a useful role in screening mixtures of complex metal hydrides to find systems suitable for H(2) storage applications. Standard methods for this task efficiently identify the lowest energy reaction mechanisms among all possible reactions involving collections of materials for which DFT calculations have been performed. The resulting mechanism can potentially differ from physical reality due to inaccuracies in the DFT functionals used, or due to other approximations made in estimating reaction free energies. We introduce an efficient method to probe the robustness of DFT-based predictions that relies on identifying reactions that are metastable relative to the lowest energy reaction path predicted with DFT. An important conclusion of our calculations is that in many examples DFT cannot unambiguously predict a single reaction mechanism for a well defined metal hydride mixture because two or more mechanisms have reaction energies that differ by a small amount. Our approach is illustrated by analyzing a series of single step reactions identified in our recent work that examined reactions with a large database of solids [Kim et al., Phys. Chem. Chem. Phys. 2011, 13, 7218]. 相似文献
106.
This article presents a simple, low-cost method of fabrication and the applications of flexible polystyrene microfluidic devices with three-dimensional (3D) interconnected microporous walls based on treatment using a solvent/non-solvent mixture at room temperature. The complete fabrication process from device design concept to working device can be completed in less than an hour in a regular laboratory setting, without the need for expensive equipment. Microfluidic devices were used to demonstrate gas generation and absorption reactions by acidifying water with carbon dioxide (CO(2)) gas. By selectively treating the microporous structures with oxygen plasma, acidification of water by acetic acid (distilled white vinegar) perfusion was also demonstrated with the same device design. 相似文献
107.
Kim Y Kim KS Kounovsky KL Chang R Jung GY dePablo JJ Jo K Schwartz DC 《Lab on a chip》2011,11(10):1721-1729
Fully stretched DNA molecules are becoming a fundamental component of new systems for comprehensive genome analysis. Among a number of approaches for elongating DNA molecules, nanofluidic molecular confinement has received enormous attentions from physical and biological communities for the last several years. Here we demonstrate a well-optimized condition that a DNA molecule can stretch almost to its full contour length: the average stretch is 19.1 μm ± 1.1 μm for YOYO-1 stained λ DNA (21.8 μm contour length) in 250 nm × 400 nm channel, which is the longest stretch value ever reported in any nanochannels or nanoslits. In addition, based on Odijk's polymer physics theory, we interpret our experimental findings as a function of channel dimensions and ionic strengths. Furthermore, we develop a Monte Carlo simulation approach using a primitive model for the rigorous understanding of DNA confinement effects. Collectively, we present a more complete understanding of nanochannel confined DNA stretching via the comparisons to computer simulation results and Odijk's polymer physics theory. 相似文献
108.
109.
Sang Soo Lee Hyun Woo Cho Sang Kyu Lim Ki Ho Han Jin Soo Han Moo Jung Chu Je Soo Ko Kyeong-Mo Yoon Yong-Gi Lee 《光学学报》2003,23(Z1)
Transmission of 40Gbit/s NRZ signal was successfully demonstrated over 219km of installed SMF in KT's Daejeon area network. After transmission, the measured power penalty was 0.5dB for all the tributary channels. 相似文献
110.
Ki Chul Park Masatsugu Fujishige Susumu Arai Morinobu Endo 《Journal of Physics and Chemistry of Solids》2008,69(10):2481-2486
High-speed agitation by a mixing blade has efficiently achieved the cutting of a large diameter (100-150 nm) of multi-walled carbon nanotubes. The cutting process is caused by an inter-collision of the nanotubes with high transfer energy. The collision-induced cutting allows for the shortening of the nanotubes without serious damage of the original graphitic layers due to the cutting effect being limited to the collision points. Furthermore, the operation under ambient atmosphere introduces oxygen-containing functional groups to the cut nanotubes. The estimated length distribution has indicated that high-speed agitation achieves a large cutting effect during a short duration of several minutes. 相似文献