Development and validation of a stability-indicating RP-UPLC method for the quantitative analysis of nabumetone in tablet dosage form

High efficiency and less run time are the basic requirements of high-speed chromatographic separations. To fulfill these requirements, a new separation technique, ultra-performance liquid chromatography (UPLC), has shown promising developments. A rapid, specific, sensitive, and precise reverse-phase UPLC method is developed for the determination of nabumetone in tablet dosage form. In this work, a new isocratic chromatographic method is developed. The newly developed method is applicable for assay determination of the active pharmaceutical ingredient. The chromatographic separation is achieved on a Waters Acquity BEH column (100 mm, i.d., 2.1 mm, 1.7 μm) within a short runtime of 2 min using a mobile phase of 5 mM ammonium acetate-acetonitrile (25:75, v/v), at a flow rate of 0.3 mL/min at an ambient temperature. Quantification is achieved with photodiode array detection at 230 nm, over the concentration range of 0.05-26 μg/mL. Forced degradation studies are also performed for nabumetone bulk drug samples to demonstrate the stability-indicating power of the UPLC method. Comparison of system performance with conventional high-performance liquid chromatography is made with respect to analysis time, efficiency, and sensitivity. The method is validated according to the ICH guidelines and is applied successfully for the determination of nabumetone in tablets.     

On the exact solutions of nonlinear diffusion-reaction equations with quadratic and cubic nonlinearities

Attempts have been made to look for the soliton content in the solutions of the recently studied nonlinear diffusion-reaction equations [R S Kaushal, J. Phys. 38, 3897 (2005)] involving quadratic or cubic nonlinearities in addition to the convective flux term which renders the system nonconservative and the corresponding Hamiltonian non-Hermitian.     

Momentum- and energy-dependence ofJ/Ψ suppression in relativistic heavy ion collisions

With a view to understand the available data on the momentum- and energy-dependences of theJ/Ψ suppression, we compute the suppression rate within the framework of a hydrodynamical evolution model for the quark-gluon plasma (QGP) formation. We make use of an ansatz for the temperature profile function which accounts not only for the space and time evolutions of QGP but also for the possibility of a mixed phase in the boundary region of the deconfined phase. While the predictions are made for the longitudinal momentum- and energy-dependences of the suppression rate, a satisfactory agreement with the available data is found for its dependences on the transverse momentum and the transverse energy.     

Fabrication of polyvinyl alcohol/chitosan oligosaccharide hydrogel: physicochemical characterizations and in vitro drug release study

Abstract

Hydrogel composites from polyvinyl alcohol and chitosan have been developed by various researchers as a function of their composition for various medical applications. Although, the solubility of chitosan in acidic solvents may limit its wide bioengineering applications. In this article, we demonstrate that polyvinyl alcohol-chitosan oligosaccharide (water soluble) to develop cross-linked hydrogel network using chemical cross linker. X ray diffraction, Fourier transform infrared spectroscopy, and wettability study of these hydrogels were also performed. Lomefloxacin drug was loaded into the hydrogels and its release profile was studied.     

MATHEMATICAL MODEL FOR THE DEFORMATION IN A MODIFIED GREEN–LINDSAY THERMOELASTIC MEDIUM WITH NONLOCAL AND TWO-TEMPERATURE EFFECTS

Journal of Applied Mechanics and Technical Physics - The present study elaborates the response of a heat source along with thermomechanical loading in a modified Green–Lindsay generalized...     

Solitary wave solutions of selective nonlinear diffusion-reaction equations using homogeneous balance method

An auto-Bäcklund transformation derived in the homogeneous balance method is employed to obtain several new exact solutions of certain kinds of nonlinear diffusion-reaction (D-R) equations. These equations arise in a variety of problems in physical, chemical, biological, social and ecological sciences.     

Crystal structures of 3/4-pyridyl-based thiosemicarbazones and related Cu and Ni coordination compounds

In this investigation, the crystal structures of the thio-ligands 3-formylpyridine 4-phenylthiosemicarbazone (C₁₃H₁₂N₄S, 1 ) and 4-benzoylpyridine 4-ethylthiosemicarbazone (C₁₅H₁₆N₄S, 2 ), and of two new coordination compounds, chlorido(3-formylpyridine 4-phenylthiosemicarbazone-κS)bis(triphenylphosphane-κP)copper(I) acetonitrile monosolvate, [CuCl(C₁₃H₁₂N₄S)(C₁₈H₁₅P)₂]·CH₃CN, 3 , and bis(3-formylpyridine 4-ethylthiosemicarbazonato-κ²N¹,S)nickel(II), [Ni(C₉H₁₁N₄S)₂], 4 , are reported. In complex 3 , the thio-ligand coordinates in a neutral form to the Cu atom through its S-donor atom, and in complex 4 , the anionic thio-ligand chelates to the Ni atom through N- and S-donor atoms. The geometry of complex 3 is distorted tetrahedral [bond angles 99.70 (5)–123.23 (5)°], with the P—Cu—P bond angle being the largest, while that of complex 4 is square planar, with trans-S—Ni—S and N—Ni—N bond angles of 180°.     

Boundary regularity of correspondences in ℂn

LetM, M′ be smooth, real analytic hypersurfaces of finite type in ℂⁿ and a holomorphic correspondence (not necessarily proper) that is defined on one side ofM, extends continuously up toM and mapsM to M′. It is shown that must extend acrossM as a locally proper holomorphic correspondence. This is a version for correspondences of the Diederich-Pinchuk extension result for CR maps.     

Study of Micellar Behavior of SDS and CTAB in Aqueous Media Containing Furosemide—A Cardiovascular Drug

Sound velocity and density measurements of aqueous solutions of the anionic surfactant SDS (sodium dodecyl sulfate) and the cationic surfactant CTAB (cetyltrimethylammonium bromide) with the drug furosemide (0.002 and 0.02 mol⋅dm⁻³) have been carried out in the temperature range 20–40 °C. From these measurements, the compressibility coefficient (β), apparent molar volume (φ _v ) and apparent molar compressibility (φ _κ ) have been computed. From electrical conductivity measurements, the critical micelle concentrations (CMCs) of SDS and CTAB has been determined in the above aqueous furosemide solutions. From the CMC values as a function of temperature, various thermodynamic parameters have been evaluated: the standard enthalpy change (DH_m^o\Delta H_{\mathrm{m}}^{\mathrm{o}}), standard entropy change (DS_m^o\Delta S_{\mathrm{m}}^{\mathrm{o}}), and standard Gibbs energy change (DG_m^o\Delta G_{\mathrm{m}}^{\mathrm{o}}) for micellization. This work also included viscosity studies of aqueous solutions of SDS and CTAB with the drug in order to determine the relative viscosity (η _r). UV-Vis studies have also been carried for the ternary drug/surfactant/water system having SDS in the concentration range 0.002–0.014 mol⋅dm⁻³. All of these parameters are discussed in terms of drug–drug, drug–solvent and drug–surfactant interactions resulting from of various electrostatic and hydrophobic interactions.     

Some aspects of shift-like automorphisms of $$\pmb {\mathbb {C}}^{\varvec{k}}$$

The goal of this article is two fold. First, using transcendental shift-like automorphisms of \(\mathbb C^k, ~k \ge 3\) we construct two examples of non-degenerate entire mappings with prescribed ranges. The first example exhibits an entire mapping of \(\mathbb C^k, ~k \ge 3\) whose range avoids a given polydisc but contains the complement of a slightly larger concentric polydisc. This generalizes a result of Dixon–Esterle in \(\mathbb C^2.\) The second example shows the existence of a Fatou–Bieberbach domain in \(\mathbb C^k,~k \ge 3\) that is constrained to lie in a prescribed region. This is motivated by similar results of Buzzard and Rosay–Rudin. In the second part we compute the order and type of entire mappings that parametrize one dimensional unstable manifolds for shift-like polynomial automorphisms and show how they can be used to prove a Yoccoz type inequality for this class of automorphisms.