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991.
992.
In this paper we prove a uniform and scale invariant boundary Harnack principle at infinity for a large class of purely discontinuous Feller processes in metric measurespaces. 相似文献
993.
Jan Turek Zdeňka Růžičková Eva Tloušťová Helena Mertlíková‐Kaiserová Jana Günterová Lubomír Rulíšek Aleš Růžička 《应用有机金属化学》2016,30(5):318-322
Two gold(I) complexes of the (NHC)AuX type bearing a triazole‐based N‐heterocyclic carbene (NHC) ligand (1‐tert‐butyl‐4‐(4‐methylphenyl)‐3‐phenyl‐1H‐1,2,4‐triazol‐4‐ium‐5‐ylidene) and various halide ligands (X = Br, I) were synthesized and characterized in solution using NMR spectroscopy as well as in the solid state using X‐ray diffraction techniques. The cytotoxic properties of both compounds and the precursor, (NHC)AuCl, were screened against a panel of human tumour cell lines including liver cancer (HepG2), cervical cancer (HeLa S3) and leukaemia (CCRF‐CEM, HL‐60) and compared to cisplatin and auranofin. It was found that the activities of the chloro and bromo derivatives were generally superior to that of cisplatin and slightly less effective compared to auranofin, except for HepG2 cells where auranofin was not as effective. In addition, the ability to induce membrane phosphatidyl serine externalization as a hallmark of apoptosis in CCRF‐CEM leukaemic cells was investigated. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
994.
Optimal trading strategies are found for an insider who is trading in two convergent stocks and is bound by margin constraints. 相似文献
995.
Tomáš Řezníček Libor Dostál Aleš Růžička Jiří Kulhánek Filip Bureš Roman Jambor 《应用有机金属化学》2011,25(3):173-179
The phosphines L1PPh2 (1) and L2PPh2 (2) containing different Y,C,Y‐chelating ligands, L1 = 2,6‐(tBuOCH2)2C6H3? and L2 = 2,6‐(Me2NCH2)2C6H3?, were treated with PdCl2 and di‐µ‐chloro‐bis[2‐[(N,N‐dimethylamino)methyl]phenyl‐C,N]‐dipalladium(II) and yielded complexes trans‐{[2,6‐(tBuOCH2)2C6H3]PPh2}2PdCl2 (3), {[2,6‐(Me2NCH2)2C6H3]PPh2} PdCl2 (4), {[2,6‐(tBuOCH2)2C6H3]PPh2}Pd(Cl)[2‐(Me2NCH2)C6H4] (5) and {[2,6‐(Me2NCH2)2C6H3]PPh2}Pd(Cl)[2‐(Me2NCH2)C6H4] (6) as the result of different ability of starting phosphines 1 and 2 to complex PdCl2. Compounds 3–6 were characterized by 1H, 13C, 31P NMR spectroscopy and ESI‐MS. The molecular structures of 3,4 and 6 were also determined by X‐ray diffraction analysis. The catalytic activity of complexes 3–6 was evaluated in the Suzuki‐Miyaura cross‐coupling reaction. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
996.
The methods of theoretical chemistry have been used to elucidate molecular properties of selected and novel antiangiogenic
agents (semaxanib, sunitinib, N-methylsunitinib, sorafenib, motesanib, ABT-869, vatalanib, vandetanib, AEE 788, CP-547632, A-1, A-2, A-3, and A-4). The geometries
and energies of these drugs have been computed using HF/6-31G(d), Becke3LYP/6-31G(d) and Becke3LYP/6-31++G(d,p) model chemistries.
Wherever possible the most stable conformations of inhibitors studied are stabilized by means of intramolecular hydrogen bonds.
Water has a remarkable effect on the geometry of the antiangiogenic agents studied. Computed partition coefficients (ALOGPS
method) varied between 2.3 and 5. Compounds studied are described as lipophilic inhibitors. Semaxanib is inhibitor with lowest
lipophilicity. The antiangiogenic agents studied are only slightly soluble in water; their computed solubility (log S) from interval between −3.4 and −5.4 is sufficient for fast absorption. Selection criteria for drug-like properties of VEGFR2
inhibitors investigated were designed. Based on these criteria, three compounds (A-2, A-3, and A-4) were selected for synthesis
and biological testing for antianiogenic activity on VEGFR2 receptor. 相似文献
997.
O. Habarova O. Bobiļeva E. Loža N. Romančikova 《Chemistry of Heterocyclic Compounds》2011,47(6):719-727
Inhibition of histone deacetylase activity appears as an original and effective approach for the treatment of cancer. A series
of novel quinoline-containing derivatives has been synthesized and found that some of these compounds possess nanomolar histone
deacetylase inhibitory activity. 相似文献
998.
A new family of five-membered cyclic nitrones bearing functional groups at positions 2 and 5 were tested in 1,3-cycloadditions with various dipolarophiles. These reactions gave the corresponding cycloadducts as single diastereomers in high yields. The reaction scope was examined, 23 compounds were isolated and fully characterized. The comparison of the reactivity was carried out by a study of reaction conversions while different nitrones or dipolarophiles were used. In addition, the exceptional reactivity of nitrone bearing benzylamino group in position 2 was studied. The formation of the nitrone complex and evaluation of its reactivity in 1,3-DC is presented. 相似文献
999.
This paper is focused on modeling of sorption and desorption kinetics as well as on equilibrium butan-1-ol vapor sorption in blended poly(dimethylsiloxane)-benzyl-3-butylimidazolium tetrafluoroborate membranes. Based on the generalized Fick’s second law, on time-dependent boundary conditions and on two models of equilibrium sorption, the diffusion coefficients of butan-1-ol were calculated from the experimental data using the finite difference modeling. Although anomalous sorption occurred at higher concentrations of butan-1-ol, the diffusion coefficients calculated from the data on sorption and desorption kinetics were in a good agreement. The increase of the ionic liquid content in poly(dimethylsiloxane) elevated the butan-1-ol equilibrium concentration in the membrane, and, at the same time, decreased the values of butan-1-ol diffusion coefficient. 相似文献
1000.