排序方式: 共有133条查询结果,搜索用时 171 毫秒
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Elena Calatrava-Pérez Luke A. Marchetti Gavin J. McManus Dylan M. Lynch Robert B. P. Elmes D. Clive Williams Thorfinnur Gunnlaugsson Eoin M. Scanlan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(3):e202103858
Real-time tracking of prodrug uptake, delivery and activation in vivo represents a major challenge for prodrug development. Herein, we demonstrate the use of novel glycosylated theranostics of the cancer pharmacophore Amonafide in highly-selective, enzymatic triggered release. We show that the use of endogenous enzymes for activated release of the therapeutic component can be observed, in real time, and monitored using one and two-photon bioimaging, offering unique insight into the prodrug pharmacokinetic profile. Furthermore, we demonstrate that the potent cytotoxicity of Amonafide is preserved using this targeted approach. 相似文献
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H. P. Gunnlaugsson H. Rasmussen L. Kristjánsson S. Steinthorsson Ö. Helgason P. Nørnberg M. B. Madsen S. Mørup 《Hyperfine Interactions》2008,182(1-3):87-101
Mössbauer spectroscopy of iron–titanium containing spinel phases is reviewed. New techniques are presented for determination of their composition using room-temperature Mössbauer spectroscopy. An example of thermal alteration processes is described. The speciality of olivine-containing basalt is briefly discussed with regard to its magnetic properties. 相似文献
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The synthesis of a novel Tb(III) luminescent probe for the detection of thiols is presented. The probe 1.Tb, possessing a maleimide moiety, as its sulfhydryl acceptor, was poorly emitting in aqueous pH 7 solution in the absence of a thiol. However, upon addition of thiols such as glutathione (GSH), large enhancements were observed, particularly within the physiological pH range. In contrast no enhancements were observed in the presence of the oxidized form of glutathione (GSSG), except in the presence of the enzyme glutathione reductase and NADPH which enabled 1.Tb to be used to observe the enzymatic reduction of GSSG to GSH in real time. 相似文献
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The self-assembly between the amidothiourea ligands 1 and 2 and Tb(III) gave rise to the formation of 1:1 and 3:1 (ligand-Tb) supramolecular architectures that were shown to be luminescent in both MeOH and in water-DMSO solutions; preliminary investigations in the latter system also showed that their emission was modulated upon interacting with anions such as acetate and phosphate due to host-guest formation. 相似文献
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H. P. Gunnlaugsson R. Sielemann T. E. M?lholt W. B. Dlamini K. Johnston R. Mantovan H. Masenda D. Naidoo W. N. Sibanda K. Bharuth-Ram M. Fanciulli H. P. Gíslason G. Langouche S. ólafsson G. Weyer 《Hyperfine Interactions》2010,197(1-3):43-52
Emission Mössbauer spectroscopy on 57Fe fed by 57Mn ions implanted in the metal oxides ZnO, MgO and Al2O3 has been performed. The implanted ions occupy different lattice sites and charge states. A magnetic part of the spectra in each oxide can be assigned to Fe3?+? ions in a paramagnetic state with unusually long relaxation time observable to temperatures up to several hundreds Kelvin. Earlier expectations that the magnetic spectra could correspond to an ordered magnetic state could not be confirmed. A clear decision for paramagnetism and against an ordered magnetic state was achieved by applying a strong magnetic field of 0.6 Tesla. The relaxation times deduced were compared to spin–lattice relaxation times from electron paramagnetic resonance (EPR). 相似文献
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H. P. Gunnlaugsson P. Bertelsen C. Butz-Jørgensen G. Klingelhöfer I. Kuvvetli M. B. Madsen J. P. Merrison P. Nørnberg H. Rasmussen G. Weyer 《Hyperfine Interactions》2005,166(1-4):511-516
Described are some applications of conversion electron Mössbauer spectroscopy (CEMS) in geosciences. It is shown how easily this technique can be applied in existing Mössbauer laboratories to investigate natural samples. Some examples demonstrate the kind of information CEMS can give on the weathering history or mechanical properties of samples. The possible application of CEMS on Mars is discussed. 相似文献
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Christophe Lincheneau Eoin Quinlan Jonathan A. Kitchen Thomas McCabe Thorfinnur Gunnlaugsson 《Supramolecular chemistry》2013,25(12):869-880
The synthesis and the photophysical studies of a new generation of time resolved luminescent systems based on calix[4]arenes alkylated at the lower rim, capable of hosting lanthanide (III) ions such as terbium and sensitising its emission, are described. Two series of ligands were designed to provide an ideal cavity to host terbium (Tb(III)) and were synthesised in high yields following two novel approaches. The tetra-alkylation, which was achieved in one step using with piperidino- and morpholino-acetamide pendant arms, provides eight donor atoms forming a binding ‘pocket’ at an ideal distance from the metal core to favour the sensitisation via the antenna effect. Of the two ligand series developed, compounds 3 and 4 possess a short spacer between the calix and the amide receptor site. The second series of ligands 6–7, designed with longer pendant amide arms, was synthesised from 2 in two steps through the ester analogue 5. The crystal structure of 3 (and 6 as shown in Supporting Information, available online) is presented. The synthesis and the photophysical studies of the four resulting complexes 3.Tb, 4.Tb, 6.Tb and 7.Tb are described in detail and in each case, successful sensitisation of the terbium emission occurred upon excitation of the phenolic scaffold of the calixarene. 相似文献
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The reaction of tetrasodium-4,4',6,6'-tetracarboxy-2,2'-bipyridine (Na(4)L) with various lanthanide ions yields a family of isostructural supramolecular {Na(2)[Ln(2)L(2)]} complexes (1-4), where Ln(III) = Eu, Nd, Gd, and Tb. Strikingly, these complexes luminesce in buffered H(2)O or D(2)O solutions in either the visible or near-IR regions, despite their high hydration states. 相似文献