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排序方式: 共有616条查询结果,搜索用时 171 毫秒
611.
Yang Zhu Peng Gong Jun Wang Junjie Cheng Wenyu Wang Huilan Cai Rujiang Ao Hongwei Huang Meili Yu Prof. Lisen Lin Prof. Xiaoyuan Chen 《Angewandte Chemie (International ed. in English)》2023,62(12):e202218407
Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there is no study exploring the effect of cell membrane unsaturation degree on CDT. Here, we report a self-reinforcing CDT agent (denoted as OA@Fe-SAC@EM NPs), consisting of oleanolic acid (OA)-loaded iron single-atom catalyst (Fe-SAC)-embedded hollow carbon nanospheres encapsulated by an erythrocyte membrane (EM), which promotes LPO to improve chemodynamic efficacy via modulating the degree of membrane unsaturation. Upon uptake of OA@Fe-SAC@EM NPs by cancer cells, Fe-SAC-catalyzed conversion of endogenous hydrogen peroxide into hydroxyl radicals, in addition to initiating the chemodynamic therapeutic process, causes the dissociation of the EM shell and the ensuing release of OA that can enrich cellular membranes with PUFAs, enabling LPO amplification-enhanced CDT. 相似文献
612.
Shang Wu Wen Shen Xuemei Ge Fen Ao Yan Zheng Yigang Wang Xiaoni Jia Yueyang Mao Yali Luo 《Macromolecular bioscience》2023,23(10):2300078
Peripheral nerve injury is a common complication of accidents and diseases. The traditional autologous nerve graft approach remains the gold standard for the treatment of nerve injuries. While sources of autologous nerve grafts are very limited and difficult to obtain. Nerve guidance conduits are widely used in the treatment of peripheral nerve injuries as an alternative to nerve autografts and allografts. However, the development of nerve conduits does not meet the needs of large gap peripheral nerve injury. Functional nerve conduits can provide a good microenvironment for axon elongation and myelin regeneration. Herein, the manufacturing methods and different design types of functional bridging nerve conduits for nerve conduits combined with electrical or magnetic stimulation and loaded with Schwann cells, etc., are summarized. It summarizes the literature and finds that the technical solutions of functional nerve conduits with electrical stimulation, magnetic stimulation and nerve conduits combined with Schwann cells can be used as effective strategies for bridging large gap nerve injury and provide an effective way for the study of large gap nerve injury repair. In addition, functional nerve conduits provide a new way to construct delivery systems for drugs and growth factors in vivo. 相似文献
613.
Dr. Wen-Long Huang Dr. Xu-Dong Wang Dr. Yu-Fei Ao Prof. Dr. Qi-Qiang Wang Prof. Dr. De-Xian Wang 《Angewandte Chemie (International ed. in English)》2023,62(23):e202302198
Inspired by the unique structure and function of the natural chloride channel (ClC) selectivity filter, we present herein the design of a ClC-type single channel molecule. This channel displays high ion transport activity with half-maximal effective concentration, EC50, of 0.10 μM, or 0.075 mol % (channel molecule to lipid ratio), as determined by fluorescent analysis using lucigenin-encapsulated vesicles. Planar bilayer lipid membrane conductance measurements indicated an excellent Cl−/K+ selectivity with a permeability ratio P /P up to 12.31, which is comparable with the chloride selectivity of natural ClC proteins. Moreover, high anion/anion selectivity (P /P =66.21) and pH-dependent conductance and ion selectivity of the channel molecule were revealed. The ClC-like transport behavior is contributed by the cooperation of hydrogen bonding and anion–π interactions in the central macrocyclic skeleton, and by the existence of pH-responsive terminal phenylalanine residues. 相似文献
614.
Weidong Ao Huijun Ren Changgen Cheng Zhishuai Fan Prof. Qing Qin Prof. Peiqun Yin Prof. Qi Zhang Prof. Lei Dai 《Angewandte Chemie (International ed. in English)》2023,62(42):e202307924
Rational design of electrocatalysts is essential to achieve desirable performance of electrochemical synthesis process. Heterostructured catalysts have thus attracted widespread attention due to their multifunctional intrinsic properties, and diverse catalytic applications with corresponding outstanding activities. Here, we report an in situ restoration strategy for the synthesis of ultrathin Pd-Ni(OH)2 nanosheets. Such Pd-Ni(OH)2 nanosheets exhibit excellent activity and selectivity towards reversible electrochemical reforming of ethylamine and acetonitrile. In the acetonitrile reduction process, Pd acts as reaction center, while Ni(OH)2 provide proton hydrogen through promoting the dissociation of water. Also ethylamine oxidation process can be achieved on the surface of the heterostructured nanosheets with abundant Ni(II) defects. More importantly, an electrolytic cell driven by solar cells was successfully constructed to realize ethylamine-acetonitrile reversible reforming. This work demonstrates the importance of heterostructure engineering in the rational synthesis of multifunctional catalysts towards electrochemical synthesis of fine chemicals. 相似文献
615.
Dr. Yu-Fei Ao Shuxin Pei Dr. Chao Xiang Marian J. Menke Prof. Lin Shen Dr. Chenghai Sun Dr. Mark Dörr Dr. Stefan Born Prof. Matthias Höhne Prof. Uwe T. Bornscheuer 《Angewandte Chemie (International ed. in English)》2023,62(23):e202301660
Amine transaminases (ATAs) are powerful biocatalysts for the stereoselective synthesis of chiral amines. Machine learning provides a promising approach for protein engineering, but activity prediction models for ATAs remain elusive due to the difficulty of obtaining high-quality training data. Thus, we first created variants of the ATA from Ruegeria sp. (3FCR) with improved catalytic activity (up to 2000-fold) as well as reversed stereoselectivity by a structure-dependent rational design and collected a high-quality dataset in this process. Subsequently, we designed a modified one-hot code to describe steric and electronic effects of substrates and residues within ATAs. Finally, we built a gradient boosting regression tree predictor for catalytic activity and stereoselectivity, and applied this for the data-driven design of optimized variants which then showed improved activity (up to 3-fold compared to the best variants previously identified). We also demonstrated that the model can predict the catalytic activity for ATA variants of another origin by retraining with a small set of additional data. 相似文献
616.
Wang Ao Shao Shu-Ren Wu He-Cheng Tian Chen-Xu Luo Feng Li Jie-Hua Li Zhen Tan Hong 《高分子科学》2023,41(6):933-941
Chinese Journal of Polymer Science - Fluorinated diols (FDO) with dangling chain were introduced into polyether urethanes (PEUs) as chain extender in order to achieve internal plasticization. Based... 相似文献