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排序方式: 共有492条查询结果,搜索用时 500 毫秒
91.
Andreas Helmstedt Marc D. Sacher Aaron Gryzia Alexander Harder Armin Brechling Norbert Müller Ulrich Heinzmann Veronika Hoeke Erich Krickemeyer Thorsten Glaser Samuel Bouvron Mikhail Fonin 《Journal of Electron Spectroscopy and Related Phenomena》2012,184(11-12):583-588
X-ray absorption spectroscopy studies of the [MnIII6CrIII]3+ single-molecule magnet deposited as a microcrystalline layer on gold substrates are presented. The oxidation state of the manganese centers changes from MnIII to MnII due to irradiation with soft X-rays. The influence of the charge-neutralizing anions on the stability of [MnIII6CrIII]3+ against soft X-ray exposure is investigated for the different anions tetraphenylborate (BPh4?), lactate (C3H5O3?) and perchlorate (ClO4?). The exposure dependence of the radiation-induced reduction process is compared for [MnIII6CrIII]3+ with the three different anions. 相似文献
92.
Ohla S Beyreiss R Fritzsche S Glaser P Nagl S Stockhausen K Schneider C Belder D 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(4):1240-1246
High-throughput screening for optimal reaction conditions and the search for efficient catalysts is of eminent importance in the development of chemical processes and for expanding the spectrum of synthetic methodologies in chemistry. In this context we report a novel approach for a microfluidic chemical laboratory integrating organic synthesis, separation and time-resolved fluorescence detection on a single microchip. The feasibility of our integrated laboratory is demonstrated by monitoring the formation of tetrahydroisoquinoline derivatives by Pictet-Spengler condensation. After on-chip reaction the products and residual starting material were separated enantioselectively on the same chip. On-chip deep UV laser-induced fluorescence detection with time-correlated single photon counting was applied for compound assignment. The system was utilized to screen reaction conditions and various substrates for Pictet-Spengler reactions on-chip. Finally, the microlab was successfully applied to investigate enantioselective reactions using BINOL-based phosphoric acids as organocatalysts. 相似文献
93.
Marija Matković Krešimir Molčanov Robert Glaser Kata Mlinarić-Majerski 《Tetrahedron》2012,68(42):8795-8804
2-(1-Adamantyl)-β-butyrolactones 3a and 3b were synthesized using very common peptide coupling reagents under mild conditions and their ring-opening reactions were then studied. These novel lactones showed pronounced stability and were resistant to cleavage upon acidic water extraction and column chromatographic purification. The adamantane moiety plays an important function in lowering the lactone reactivity by protecting the electrophilic sites on the four membered ring via steric hindrance. However under certain conditions, both O–C(carbonyl) and O–C(alkyl) bond-cleavage ring-opening reactions were observed. Bond-cleavage at physiological temperature makes these novel lactones especially noteworthy. Novel adamantyl-β-butyrolactones have a potential to act as biomembrane soluble amphiphiles that might exhibit a combination of stability and biological activity with the latter hopefully predominating. 相似文献
94.
95.
T Glaser K Rose S E Shadle B Hedman K O Hodgson E I Solomon 《Journal of the American Chemical Society》2001,123(3):442-454
X-ray absorption spectroscopy (XAS) at the sulfur ( approximately 2470 eV) and chlorine ( approximately 2822 eV) K-edges has been applied to a series of 4Fe-4S model complexes. These are compared to 2Fe-2S model complexes to obtain insight into the localized ground state in the mixed-valence dimer versus the delocalized ground state in the mixed-valence tetramer. The preedges of hypothetical delocalized mixed-valence dimers [Fe(2)S(2)](+) are estimated using trends from experimental data and density functional calculations, for comparison to the delocalized mixed-valence tetramer [Fe(4)S(4)](2+). The differences between these two mixed-valence sites are due to the change of the sulfide-bridging mode from micro(2) to micro(3). The terminal chloride and thiolate ligands are used as spectator ligands for the electron density of the iron center. From the intensity of the preedge, the covalency of the terminal ligands is found to increase in the tetramer as compared to the dimer. This is associated with a higher effective nuclear charge on the iron in the tetramer (derived from the energies of the preedge). The micro(3)-bridging sulfide in the tetramer has a reduced covalency per bond (39%) as compared to the micro(2)-bridging sulfide in the dimer (51%). A simple perturbation model is used to derive a quadratic dependence of the superexchange coupling constant J on the covalency of the metal ions with the bridging ligands. This relationship is used to estimate the superexchange contribution in the tetramer (J = -156 cm(-)(1)) as compared to the mixed-valence dimer (J = -360 cm(-)(1)). These results, combined with estimates for the double exchange and the vibronic coupling contributions of the dimer sub-site of the tetramer, lead to a delocalized S(t) = (9)/(2) spin ground state for the mixed-valence dimer in the tetramer. Thus, the decrease in the covalency, hence the superexchange pathway associated with changing the bridging mode of the sulfides from micro(2) to micro(3) on going from the dimer to the tetramer, significantly contributes to the delocalization of the excess electron over the dimer sub-site in the tetramer. 相似文献
96.
R Glaser 《The Journal of organic chemistry》2001,66(3):771-779
The potential energy surface of acetylsalicylic acid, aspirin, has been explored at the RHF/6-31G* and B3LYP/6-31G* levels, and single-point calculations were performed at levels up to B3LYP/6-311G**//B3LYP/6-31G*. All conformational isomers have been located, the thermochemical functions have been computed, and relative energies and free enthalpies were determined. The conformational space of aspirin is spanned by three internal coordinates, and these are the carboxylic acid C-O conformation (s-trans preferred by about 7 kcal/mol), the C-COOH conformation (Z preferred unless there are H-bonding opportunities), and the ester C-O conformation (s-trans preferred by about 4 kcal/mol). There are nine aspirin isomers since one of the conformers realizes hydrogen-bonding structure isomerism as well. Neighboring group interactions are discussed with reference to the intrinsic properties of benzoic acid and phenyl acetate. The intrinsic conformational preference energies for benzoic acid and phenyl acetate are not additive. The acid s-trans preference energies differ by as much as 9 kcal/mol depending on the Ph-COOH and ester conformations. Similarly, the E-preference energies about the Ph-COOH bond vary by as much as 6 kcal/mol depending on the ester conformation. The structural discussion suggests an overall ortho repulsion between the functional groups in all aspirin isomers including the intramolecularly hydrogen-bonded isomers. The isodesmic reaction between the most stable conformers of benzoic acid and phenyl acetate to form aspirin and benzene is found to be endothermic by 2.7 kcal/mol and provides compelling evidence for and a quantitative measure of ortho repulsion. The ortho repulsion of 2.7 kcal/mol is a lower limit, and the ortho repulsion can increase to as much as 6 kcal/mol in some aspirin isomers. 相似文献
97.
The Material Force Method (MFM) and the Extended Finite Element Method (X-FEM), both have been major subjects of computational fracture mechanics in recent time. Thus combining the advantages of both concepts [1, 2] seems a promising approach to describe the behaviour of discontinuities such as cracks in otherwise continuous bodies. As the X-FEM models a crack independently of the mesh, the crack tip is in general not located at a node which is why a central question is, which nodal material forces do contribute to the resulting material force vector at the crack tip. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
98.
Christian Hundshammer Martin Grashei Alexandra Greiner Prof. Dr. Steffen J. Glaser Dr. Franz Schilling 《Chemphyschem》2019,20(6):798-802
Hyperpolarization is a method to enhance the nuclear magnetic resonance signal by up to five orders of magnitude. However, the hyperpolarized (HP) state is transient and decays with the spin-lattice relaxation time (T1), which is on the order of a few tens of seconds. Here, we analyzed the pH-dependence of T1 for commonly used HP 13C-labelled small molecules such as acetate, alanine, fumarate, lactate, pyruvate, urea and zymonic acid. For instance, the T1 of HP pyruvate is about 2.5 fold smaller at acidic pH (25 s, pH 1.7, B0=1 T) compared to pH close to physiological conditions (66 s, pH 7.3, B0=1 T). Our data shows that increasing hydronium ion concentrations shorten the T1 of protonated carboxylic acids of most of the analyzed molecules except lactate. Furthermore it suggests that intermolecular hydrogen bonding at low pH can contribute to this T1 shortening. In addition, enhanced proton exchange and chemical reactions at the pKa appear to be detrimental for the HP-state. 相似文献
99.
100.
Katharina Gibson Markus Strbele Bjrn Blaschkowski Jochen Glaser Martina Weisser Radhakrishnan Srinivasan Heinz‐Jürgen Kolb Hans‐Jürgen Meyer 《无机化学与普通化学杂志》2003,629(10):1863-1870
Solid state metathesis reactions have been studied in fused silica tubes, by differential thermal analysis, and by X‐ray powder diffraction. A selection of reactions between metal (La, Nb, and Ni) chlorides and lithium nitride or lithium acetylide were investigated to get more insight into reaction pathways and intermediate reaction stages that may be adopted on course of the formation of metal nitrides or carbides. Intermediate compounds are considered to be important because they can control the reactivity of a system. Such compounds were traced by changing the molar ratios of reaction partners away from the salt‐balanced binary metal nitride or carbide target compositions. New preparative perspectives are discovered when metal chlorides were reacted with lithium nitridoborate or lithium cyanamide. Due to their reductive nature towards several d‐block metal chlorides, (BN2)3‐ and (CN2)2‐ react to form metals or metal nitrides plus X‐ray amorphous BN, and probably C3N4. With lanthanum chloride they can react to form nitridoborates and nitridocarbonates. The metathesis reaction between lithium cyanamide and cyanuric chloride (C3N3Cl3) instead of metal chloride was studied for the synthesis of C3N4. 相似文献