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91.
Cem Yamali Feyza Sena Engin Sinan Bilginer Mehtap Tugrak Dilan Ozmen Ozgun Gulsen Ozli Serkan Levent Begum Nurpelin Saglik Yusuf Ozkay Halise Inci Gul 《Journal of heterocyclic chemistry》2021,58(1):161-171
Chalcones targeting neurodegenerative diseases have been known as attractive structures in drug design and discovery. In this study, phenothiazine-based chalcones as ChEs and MAOs inhibitors were designed and synthesized via base-catalyzed Claisen-Schmidt condensation, and chemical structures of the compounds were elucidated by NMRs and HRMS. Compounds 3 and 9 showed promising inhibition potency against AChE enzyme with IC50 values of 0.221 μM and 0.053 μM while compound 9 displayed remarkable inhibition potency toward MAO-B enzyme with IC50 value of 0.048 μM. Compound 9 , as a dual-target inhibitor, selectively inhibited AChE and MAO-B enzymes. This promising behavior is an advantage for the compound since MAO-B and AChE inhibition have a role in Alzheimer's disease. Fused tricyclic ring systems such as phenothiazine incorporated with chalcone moiety being multitargeting ligands may help scientists for the rational design of novel lead compounds targeting neurodegenerative illnesses. 相似文献
92.
Gul R. Badshah A. Altaf A. Ali Tabassum S. Zia M. 《Russian Journal of General Chemistry》2017,87(11):2684-2689
Russian Journal of General Chemistry - Six new ferrocenyl guanidines were synthesized and characterized by elemental analysis, FT-IR and 1H and 13C NMR. Compounds 1–6 were screened for... 相似文献
93.
Recent NMR experiments by Singer et al. [Singer, Phys. Rev. Lett. 95, 236403 (2005).] showed a deviation from Fermi-liquid behavior in carbon nanotubes with an energy gap evident at low temperatures. Here, a comprehensive theory for the magnetic field and temperature dependent NMR 13C spin-lattice relaxation is given in the framework of the Tomonaga-Luttinger liquid. The low temperature properties are governed by a gapped relaxation due to a spin gap ( approximately 30 K), which crosses over smoothly to the Luttinger liquid behavior with increasing temperature. 相似文献
94.
Exact ground states of interacting electrons on the diamond Hubbard chain in a magnetic field are constructed which exhibit a wide range of properties such as flat-band ferromagnetism and correlation-induced metallic, half-metallic, or insulating behavior. The properties of these ground states can be tuned by changing the magnetic flux, local potentials, or electron density. 相似文献
95.
Rhodium‐Catalyzed (5+1) Annulations Between 2‐Alkenylphenols and Allenes: A Practical Entry to 2,2‐Disubstituted 2H‐Chromenes 下载免费PDF全文
Noelia Casanova Andrés Seoane Prof. José L. Mascareñas Dr. Moisés Gulías 《Angewandte Chemie (International ed. in English)》2015,54(8):2374-2377
Readily available alkenylphenols react with allenes under rhodium catalysis to provide valuable 2,2‐disubstituted 2H‐chromenes. The whole process, which involves the cleavage of one C? H bond of the alkenyl moiety and the participation of the allene as a one‐carbon cycloaddition partner, can be considered a simple, versatile, and atom‐economical (5+1) heteroannulation. The reaction tolerates a broad range of substituents both in the alkenylphenol and in the allene, and most probably proceeds through a mechanism involving a rhodium‐catalyzed C? C coupling followed by two sequential pericyclic processes. 相似文献
96.
The effective s–d spin interaction is derived exactly for the single-impurity Anderson model via a unitary transformation. This unitary transformation was calculated up to infinite order and no restrictions were imposed upon the coefficients of the Hubbard interaction and the hybridization. We also discuss briefly the impact of the obtained result on the magnetic properties of several Kondo compounds. This will shed new light on the understanding of the competition between the Kondo effect and the Ruderman–Kittel–Kasuya–Yosida interaction and reinterpret the Doniach diagram. 相似文献
97.
A. G. Krivenko V. A. Kurmaz A. S. Kotkin R. A. Manzhos L. M. Korotaeva V. P. Gul’tyai 《Russian Journal of Electrochemistry》2011,47(10):1129-1133
Intermediates (IM) of methyl(2-pyridyl)sulfone (MPS) and tert-butyl(2-pyridyl)sulfone (TBPS) formed upon the transfer of the
first electron are studied by methods of laser photoelectron emission (LPE). The capture constants of solvated electrons by
the MPS and TBPS molecules were determined. The time-resolved voltammograms of each sulfone measured in water-organic mixtures
(20–80% ethanol or 60% DMSO) are found to demonstrate a redox wave with half-wave potentials E
1/2 = −1.34 and −1.37 V for MPS and TBPS, respectively. The dependence of rate constants for the one-electron IM reduction and
oxidation on the potential is shown to obey the slow-discharge equation and the absolute magnitudes of rate constants are
determined. The characteristic times of homogeneous transformations (decomposition, protonation) of MPS and TBPS radical anions
do not exceed 3 × 10−7 s. The LPE data are compared with the results of preparative electrolysis and the mechanisms of both electrochemical and
homogeneous reactions of IM are discussed. 相似文献
98.
Mete E Gul HI Bilginer S Algul O Topaloglu ME Gulluce M Kazaz C 《Molecules (Basel, Switzerland)》2011,16(6):4660-4671
The development of resistance to current antifungal therapeutics drives the search for new effective agents. The fact that several acetophenone-derived Mannich bases had shown remarkable antifungal activities in our previous studies led us to design and synthesize some acetophenone-derived Mannich bases, 1-8 and 2-acetylthiophene-derived Mannich base 9, 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochloride, to evaluate their antifungal activities. The designed chemical structures have α,β-unsaturated ketone moieties, which are responsible for the bioactivities of the Mannich bases. The aryl part was C?H?(1); 4-CH?C?H? (2); 4-CH?OC?H? (3); 4-ClC?H? (4); 4-FC?H? (5); 4-BrC?H? (6); 4-HOC?H? (7); 4-NO?C?H? (8); and C?H?S(2-yl) (9). In this study the designed compounds were synthesized by the conventional heating method and also by the microwave irradiation method to compare these methods in terms of reaction times and yields to find an optimum synthetic method, which can be applied for the synthesis of Mannich bases in further studies. Since there are limited number of studies reporting the synthesis of Mannich bases by microwave irradiation, this study may also contribute to the general literature on Mannich bases. Compound 7 was reported for the first time. Antifungal activities of all compounds and synthesis of the compounds by microwave irradiation were also reported for the first time by this study. Fungi (15 species) were used for antifungal activity test. Amphotericin B was tested as an antifungal reference compound. In conclusion, compounds 1-6, and 9, which had more potent (2-16 times) antifungal activity than the reference compound amphotericin B against some fungi, can be model compounds for further studies to develop new antifungal agents. In addition, microwave irradiation can be considered to reduce reaction period, while the conventional method can still be considered to obtain compounds with higher reaction yields in the synthesis of new Mannich bases. 相似文献
99.
Influences of Marangoni convection and variable magnetic field on hybrid nanofluid thin-film flow past a stretching surface 下载免费PDF全文
Noor Wali Khan Arshad Khan Muhammad Usman Taza Gul Abir Mouldi and Ameni Brahmia 《中国物理 B》2022,31(6):64403-064403
Investigations on thin-film flow play a vital role in the field of optoelectronics and magnetic devices. Thin films are reasonably hard and thermally stable but quite fragile. The thermal stability of a thin film can be further improved by incorporating the effects of nanoparticles. In the current work, a stretchable surface is considered upon which hybrid nanofluid thin-film flow is taken into account. The idea of augmenting heat transmission by making use of a hybrid nanofluid is a focus of the current work. The flow is affected by variations in the viscous forces, along with viscous dissipation effects and Marangoni convection. A time-constrained magnetic field is applied in the normal direction to the flow system. The equations governing the flow system are shifted to a non-dimensional form by applying similarity variables. The homotopy analysis method is employed to find the solution to the resultant equations. It is noticed in this study that the flow characteristics decline with augmentation of magnetic, viscosity and unsteadiness parameters while they increase with enhanced values of thin-film parameters. Thermal characteristics are supported by increasing values of the Eckert number and the unsteadiness parameter and opposed by the viscosity parameter and Prandtl number. The numerical impact of different emerging parameters upon skin friction and the Nusselt number is calculated in tabular form. A comparison of current work with established results is carried out, with good agreement. 相似文献
100.
This paper described a new approach for the preconcentration of lead (Pb2+) by temperature controlled ionic liquid-dispersive liquid phase microextraction (TIL-DLME) prior to analyzing by flame atomic absorption spectrometry (FAAS). An ionic liquid (IL) 1-Butyl-3-methylimidazolium hexafluorophosphate [C4MIM][PF6] was used as an extractant solvent. The Pb2+ was complexed with ammonium pyrrolidinedithiocarbamate (APDC) and then entered into the infinite IL drops at high temperature (> 70 °C). Important variables affecting the microextraction efficiency such as pH, ligand concentration, amount of IL, temperature and incubation time were investigated. The results showed that the coexistent ions had no obvious negative effect on the determination of Pb2+. In the optimum experimental conditions, the limit of detection (LOD) and the enhancement factor (EF) were 0.13 μg L? 1 and 93, respectively. The relative standard deviation (RSD) of 10 μg L? 1 Pb2+ was 4.3%. The developed method was validated by determining Pb2+ in certified reference material (CRM) and the results showed that the determined values of Pb2+ were in good agreement with the certified value. The proposed method was applied satisfactorily for the preconcentration of Pb2+ in acid digested blood samples of children with different respiratory disorders. 相似文献