全文获取类型
收费全文 | 1485篇 |
免费 | 25篇 |
专业分类
化学 | 785篇 |
晶体学 | 6篇 |
力学 | 83篇 |
数学 | 242篇 |
物理学 | 394篇 |
出版年
2018年 | 14篇 |
2016年 | 21篇 |
2015年 | 22篇 |
2014年 | 14篇 |
2013年 | 118篇 |
2012年 | 18篇 |
2011年 | 25篇 |
2010年 | 13篇 |
2009年 | 14篇 |
2006年 | 26篇 |
2002年 | 28篇 |
2001年 | 17篇 |
2000年 | 23篇 |
1999年 | 18篇 |
1998年 | 28篇 |
1997年 | 24篇 |
1996年 | 30篇 |
1995年 | 20篇 |
1994年 | 21篇 |
1993年 | 14篇 |
1992年 | 22篇 |
1991年 | 26篇 |
1990年 | 20篇 |
1989年 | 25篇 |
1988年 | 33篇 |
1987年 | 24篇 |
1986年 | 21篇 |
1985年 | 26篇 |
1984年 | 30篇 |
1983年 | 29篇 |
1982年 | 28篇 |
1981年 | 25篇 |
1980年 | 19篇 |
1979年 | 32篇 |
1978年 | 31篇 |
1977年 | 33篇 |
1976年 | 48篇 |
1975年 | 42篇 |
1974年 | 48篇 |
1973年 | 58篇 |
1972年 | 38篇 |
1971年 | 39篇 |
1970年 | 29篇 |
1969年 | 24篇 |
1968年 | 25篇 |
1967年 | 20篇 |
1966年 | 13篇 |
1964年 | 13篇 |
1960年 | 16篇 |
1959年 | 17篇 |
排序方式: 共有1510条查询结果,搜索用时 224 毫秒
71.
72.
73.
Dr. Anna Notaro Marta Jakubaszek Severin Koch Dr. Riccardo Rubbiani Dr. Orsolya Dömötör Dr. Éva A. Enyedy Mazzarine Dotou Dr. Fethi Bedioui Mickaël Tharaud Dr. Bruno Goud PD Dr. Stefano Ferrari Prof. Dr. Enzo Alessio Dr. Gilles Gasser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(22):4997-5009
Cancer is one of the main causes of death worldwide. Chemotherapy, despite its severe side effects, is to date one of the leading strategies against cancer. Metal-based drugs present several potential advantages when compared to organic compounds and they have gained trust from the scientific community after the approval on the market of the drug cisplatin. Recently, we reported the ruthenium complex ([Ru(DIP)2(sq)](PF6) (where DIP is 4,7-diphenyl-1,10-phenantroline and sq is semiquinonate) with a remarkable potential as chemotherapeutic agent against cancer, both in vitro and in vivo. In this work, we analyse a structurally similar compound, namely [Ru(DIP)2(mal)](PF6), carrying the flavour-enhancing agent approved by the FDA, maltol (mal). To possess an FDA approved ligand is crucial for a complex, whose mechanism of action might include ligand exchange. Herein, we describe the synthesis and characterisation of [Ru(DIP)2(mal)](PF6), its stability in solutions and under conditions that resemble the physiological ones, and its in-depth biological investigation. Cytotoxicity tests on different cell lines in 2D model and on HeLa MultiCellular Tumour Spheroids (MCTS) demonstrated that our compound has higher activity than cisplatin, inspiring further tests. [Ru(DIP)2(mal)](PF6) was efficiently internalised by HeLa cells through a passive transport mechanism and severely affected the mitochondrial metabolism. 相似文献
74.
Émeline Schmisser 《Stochastic Processes and their Applications》2019,129(12):5364-5405
In this article, we consider a jump diffusion process , with drift function , diffusion coefficient and jump coefficient . This process is observed at discrete times . The sampling interval tends to 0 and the time interval tends to infinity. We assume that is ergodic, strictly stationary and exponentially -mixing. We use a penalized least-square approach to compute adaptive estimators of the functions and . We provide bounds for the risks of the two estimators. 相似文献
75.
76.
Applying an A.C. electric field to a planar oriented SC* liquid crystal sample, a shear flow occurs parallel to the bounding plates and perpendicular to the helical axis. We have investigated this so-called electromechanical effect by applying different D.C. bias electric fields superposed on a constant A.C. field. The amplitude of the mechanical vibration was measured versus the bias field in different samples. From the results, structural models of the surface stabilized and unwound samples were tested. 相似文献
77.
78.
Lublóy Éva Biró András Hlavička Viktor Németh Zsolt Csanaky Judit 《Journal of Thermal Analysis and Calorimetry》2022,147(21):11693-11704
Journal of Thermal Analysis and Calorimetry - Fire protection of steel structures is playing an increasingly important role nowadays. The fire protection of steel structures can be solved with... 相似文献
79.
RENÉ A. SALINAS WILLIAM H. STIVER JOSEPH L. CORN SUZANNE LENHART CHARLES COLLINS MARGUERITE MADDEN KURT C. VERCAUTEREN BRANDON B. SCHMIT ELLEN KASARI AGRICOLA ODOI GRAHAM HICKLING HAMISH MCCALLUM 《Natural Resource Modeling》2015,28(1):18-36
The expansion of feral hog (Sus scrofa) populations in the United States has resulted in increased efforts to develop and implement control strategies designed to minimize the impacts done by this invasive species. We describe an individual‐based model for feral hogs in Great Smoky Mountains National Park (GSMNP). The objectives of the model are to provide an understanding of the population dynamics of this feral hog population and to determine the efficacy of the annual harvest as a population control method. Results suggest that the dynamics of the population are driven by fall hard mast production and the GSMNP harvests currently limit growth of the population, but these control efforts have not reduced the population. 相似文献
80.
A Bis(pyridine N‐oxide) Analogue of DOTA: Relaxometric Properties of the GdIII Complex and Efficient Sensitization of Visible and NIR‐Emitting Lanthanide(III) Cations Including PrIII and HoIII 下载免费PDF全文
Henrique F. Carvalho Dr. João M. C. Teixeira Carlos T. B. Paula Prof. Petr Hermann Dr. Carlos Platas‐Iglesias Prof. Stephane Petoud Prof. Éva Tóth Prof. Carlos F. G. C. Geraldes 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(45):14834-14845
We report the synthesis of a cyclen‐based ligand (4,10‐bis[(1‐oxidopyridin‐2‐yl)methyl]‐1,4,7,10‐tetraazacyclododecane‐1,7‐diacetic acid= L1 ) containing two acetate and two 2‐methylpyridine N‐oxide arms anchored on the nitrogen atoms of the cyclen platform, which has been designed for stable complexation of lanthanide(III) ions in aqueous solution. Relaxometric studies suggest that the thermodynamic stability and kinetic inertness of the GdIII complex may be sufficient for biological applications. A detailed structural study of the complexes by 1H NMR spectroscopy and DFT calculations indicates that they adopt an anti‐Δ(λλλλ) conformation in aqueous solution, that is, an anti‐square antiprismatic (anti‐SAP) isomeric form, as demonstrated by analysis of the 1H NMR paramagnetic shifts induced by YbIII. The water‐exchange rate of the GdIII complex is ${k{{298\hfill \atop {\rm ex}\hfill}}}$ =6.7×106 s?1, about a quarter of that for the mono‐oxidopyridine analogue, but still about 50 % higher than the ${k{{298\hfill \atop {\rm ex}\hfill}}}$ of GdDOTA (DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid). The 2‐methylpyridine N‐oxide chromophores can be used to sensitize a wide range of LnIII ions emitting in both the visible (EuIII and TbIII) and NIR (PrIII, NdIII, HoIII, YbIII) spectral regions. The emission quantum yield determined for the YbIII complex (${Q{{{\rm L}\hfill \atop {\rm Yb}\hfill}}}$ =7.3(1)×10?3) is among the highest ever reported for complexes of this metal ion in aqueous solution. The sensitization ability of the ligand, together with the spectroscopic and relaxometric properties of its complexes, constitute a useful step forward on the way to efficient dual probes for optical imaging (OI) and MRI. 相似文献