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11.
Blundell Tom L. Bolanos-Garcia Victor Chirgadze Dimitri Y. Harmer Nicholas J. Lo Thomas Pellegrini Luca Sibanda B. Lynn 《Structural chemistry》2002,13(3-4):405-412
Signaling in living systems needs to achieve high specificity, to be reversible, and to achieve high signal to noise. Signaling mediated by multiprotein systems has evolved that avoids the requirement for high-affinity binary complexes that would be difficult to reverse and which, in the overcrowded cell, would lead to excessive noise in the system. Symmetrical structures are only occasionally formed. When they are, it is principally to colocate components, for example, the tyrosyl kinases of growth factors, where dimers form. Symmetry is, however, often broken, presumably to create more sensitivity and specificity in the signaling system by assembling other components, into higher-order multiprotein systems. The binding of a single heparin to two 1:1 FGF:FGFR complexes is an example, as is the binding of a single ligase to the Xrcc4 dimer, perhaps so creating a further DNA-binding site. 相似文献
12.
Dimitri Leemans 《Designs, Codes and Cryptography》2003,29(1-3):177-178
We announce the classification of all firm and residually connected geometries satisfying the conditions (I P)2 and (2T)1 and on which the Mathieu group M 22 acts flag-transitively and residually weakly primitively. The complete list of geometries is available as a supplement to this note [6]. 相似文献
13.
Dimitri Leemans 《Journal of Geometry》2004,79(1-2):146-155
We construct nine rank five incidence geometries that are firm and residually connected
and on which the Mathieu group M22 acts flag-transitively. The constructions use
mainly objects arising from the Steiner systemS(3, 6, 22).
One of these geometries was constructed by Meixner and Pasini in [10]. Three of them
are obtained from the geometry of Meixner and Pasini using doubling (see [8] or [12]) or similar
constructions. The remaining five are new and four of them have a star diagram. These
latter four geometries are constructed using special partitions of the 22 points of
the Steiner system S(3, 6, 22). 相似文献
14.
M. Yu. Berezkin E. G. Polyakov V. V. Turygin L. V. Kaabak A. V. Khudenko A. P. Tomilov 《Russian Journal of Applied Chemistry》2008,81(8):1360-1363
Anodic dissolution of ferroniobium in anhydrous methanol in the presence of sodium methylate was studied. The possibility of recovering pure hexamethoxyniobate from the electrolyzate and its conversion into niobium methylate with an iron content not exceeding 0.01% was analyzed. 相似文献
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Dimitri Markushevich Vladimir B. Matveev Armando Treibich 《Letters in Mathematical Physics》2006,76(2-3):109-109
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18.
E. E. Sergeev P. V. Fabinskii B. V. Polyakov V. A. Fedorov 《Russian Journal of Inorganic Chemistry》2006,51(4):687-690
The solubility of acetoacetylferrocene and 1,1′-bis(acetoacetyl)ferrocene in water and aqueous ethanol at various temperatures is studied over a wide solvent composition range. The solubilities of both compounds increase as the temperature or ethanol concentration is raised, particularly in the case of acetoacetylferrocene. The dissolution of both β-diketones is accompanied by positive changes in enthalpy and entropy. 相似文献
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