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41.
It has been proposed to rise Venice by injecting CO2 into an aquifer lying 600–800 m below its lagoon. It is shown that because of the prevailing ambient conditions in the aquifer phase change of CO2 cannot be avoided. The ensuing change of specific volume and compressibility will inhibit a uniform uplift pattern which is needed to avoid cracks in historical buildings. Further, both liquid and gaseous CO2 produce capillary effects at the contact surface with water in the voids of the reservoir rock and this affects its mechanical response. Hence further non homogeneity in the uplift pattern will be produced. This prevents the use of CO2 in the proposed conditions. 相似文献
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Simone Zanella Dr. Michele Mingozzi Alberto Dal Corso Dr. Roberto Fanelli Dr. Daniela Arosio Prof. Dr. Marco Cosentino Dr. Laura Schembri Dr. Franca Marino Dr. Marta De Zotti Prof. Dr. Fernando Formaggio Dr. Luca Pignataro Prof. Dr. Laura Belvisi Prof. Dr. Umberto Piarulli Prof. Dr. Cesare Gennari 《ChemistryOpen》2015,4(5):633-641
A dual-action ligand targeting both integrin αVβ3 and vascular endothelial growth factor receptors (VEGFRs), was synthesized via conjugation of a cyclic peptidomimetic αVβ3 Arg-Gly-Asp (RGD) ligand with a decapentapeptide. The latter was obtained from a known VEGFR antagonist by acetylation at the Lys13 side chain. Functionalization of the precursor ligands was carried out in solution and in the solid phase, affording two fragments: an alkyne VEGFR ligand and the azide integrin αVβ3 ligand, which were conjugated by click chemistry. Circular dichroism studies confirmed that both the RGD and VEGFR ligand portions of the dual-action compound substantially adopt the biologically active conformation. In vitro binding assays on isolated integrin αVβ3 and VEGFR-1 showed that the dual-action conjugate retains a good level of affinity for both its target receptors, although with one order of magnitude (10/20 times) decrease in potency. The dual-action ligand strongly inhibited the VEGF-induced morphogenesis in Human Umbilical Vein Endothelial Cells (HUVECs). Remarkably, its efficiency in preventing the formation of new blood vessels was similar to that of the original individual ligands, despite the worse affinity towards integrin αVβ3 and VEGFR-1. 相似文献
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D. Schürmann A. Di Leva L. Gialanella D. Rogalla F. Strieder N. De Cesare A. D'Onofrio G. Imbriani R. Kunz C. Lubritto A. Ordine V. Roca C. Rolfs M. Romano F. Schümann F. Terrasi H. -P. Trautvetter 《The European Physical Journal A - Hadrons and Nuclei》2005,26(2):301-305
The total cross-section of 12C(α,γ)16O was measured for the first time by a direct and ungated detection of the 16O recoils. This measurement in inverse kinematics using the recoil mass separator ERNA in combination with a windowless He
gas target allowed to collect data with high precision in the energy range E = 1.9 to 4.9 MeV. The data represent new information for the determination of the astrophysical S(E) factor. 相似文献
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An analysis of the electronic structure in beryllium slabs with an ab initio LCAO HF method is presented. Band structure, electronic density and density of states were determined for thin films of 1 to 4 atomic layers of Be. A comparison of the electronic structure in films of different thickness with the situation found for bulk Be and Be clusters shows strong modifications in the surface region and a progressive reconstruction of the bulk bonds. 相似文献
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The spectral density method in classical statistical mechanics is formulated and application to a linear classical spin system is made in the simplest approximation. 相似文献
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Bugamelli F Mandrioli R Cavallini A Baccini C Conti M Raggi MA 《Journal of separation science》2006,29(15):2322-2329
A precise and feasible HPLC method has been developed for the analysis of amphetamine (AMPH), methamphetamine (MAMPH) and methylenedioxymethamphetamine (MDMA, ecstasy) in human urine. A chromatographic run on a C8 Genesis (150 mm x 4.6 mm, 5 microm) column maintained at 30 degrees C lasts about 17 min, using a mobile phase composed of ACN (12%) and a pH 2.5 phosphate buffer (88%) containing 0.3% triethylamine. Mirtazapine was used as the internal standard. Good linearity was found in the 100-2000 ng/mL concentration range for AMPH and MAMPH and in the 12-2000 ng/mL concentration range for MDMA. The pretreatment of urine samples was carried out by means of a careful SPE procedure on C2 cartridges. The extraction yields were very satisfactory for all analytes, with average values greater than 97%. The leading conditions allowed the determination of AMPH, MAMPH and MDMA with satisfactory precision and accuracy. The method has been successfully applied to the determination of the analytes in urine of AMPH users. 相似文献