Image quality and diagnostic performance of silicone-specific breast MRI

Purpose

To compare the image quality of three techniques and diagnostic performance in detecting implant rupture.

Materials and Methods

The study included 161 implants for the evaluation of image quality, composed of water-saturated short TI inversion recovery (herein called “water-sat STIR”), three-point Dixon techniques (herein called “Dixon”), and short TI inversion recovery fast spin-echo with iterative decomposition of silicone and water using least-squares approximation (herein called “STIR IDEAL”) and included 41 implants for the evaluation of diagnostic performance in detecting rupture, composed of water-sat STIR and STIR IDEAL.Six image quality categories were evaluated and three classifications were used: normal implant, possible rupture, and definite rupture.

Results

Statistically significant differences were noted for the image quality categories (p < 0.001). STIR IDEAL was superior or equal to water-sat STIR in all image quality categories except artifact effects and superior to Dixon in all categories. Water-sat STIR performed the poorest for water suppression uniformity.The sensitivity and specificity in detecting implant rupture of STIR-IDEAL were 81.8 % and 77.8 % and the difference between two techniques was not statistically significant.

Conclusion

STIR-IDEAL is a useful silicone-specific imaging technique demonstrating more robust water suppression and equivalent diagnostic accuracy for detecting implant rupture, than water-sat STIR, at the cost of longer scan time and an increase in minor motion artifacts.     

Reciprocal Response of Human Oral Epithelial Cells to Internalized Silica Nanoparticles

Silica nanoparticles (SiO₂ NPs) are one of the most widely used engineered nanoparticles and can been found in a wide range of consumer products. Despite their massive global production scale, little is known about their potential effects in the context of unintended exposure or ingestion. Using TR146 cells as an in vitro model of the human oral buccal mucosa, the uptake, spatial intracellular distribution, reactive oxygen species (ROS) production, inflammatory response, and cytotoxic effects of commercial SiO₂ NPs are examined. SiO₂ NPs are shown to dock and cross the cellular membrane barrier in a dose–time‐dependent manner. Confocal sectioning reveals translocation of SiO₂ NPs into the cell nucleus after 12 h of exposure. A concentration threshold of more than 500 × 10^?6 m is observed, above which SiO₂ NPs are shown to exert significant oxidative stress with concomitant upregulation of inflammatory genes IL6 and TNFA. Further analysis of the p53 pathway and a series of apoptotic and cell cycle biomarkers reveals intracellular accumulation of SiO₂ NPs exert marginal nanotoxicity. Collectively, this study provides important information regarding the uptake, intracellular distribution, and potential adverse cellular effects of SiO₂ NPs commonly found in consumer products in the human oral epithelium.     

Patterns in stock market movements tested as random number generators

This paper shows that tests of Random Number Generators (RNGs) may be used to test the Efficient Market Hypothesis (EMH). It uses the Overlapping Serial Test (OST), a standard test in RNG research, to detect anomalous patterns in the distribution of sequences of stock market movements up and down. Our results show that most stock markets exhibit idiosyncratic recurrent patterns, contrary to the efficient market hypothesis; also that OST detects a different kind of non-randomness to standard econometric long- and short-memory tests. Exposure of these anomalies should contribute to making markets more efficient.     

On the Enumeration of Non-Crossing Pairings of Well-Balanced Binary Strings

A non-crossing pairing on a binary string pairs ones and zeroes such that the arcs representing the pairings are non-crossing. A binary string is well-balanced if it is of the form ${1^{a_1} 0^{a_1}1^{a_2} 0^{a_2} . . .1^{a_r} 0^{a_r}}$ . In this paper we establish connections between non-crossing pairings of well-balanced binary strings and various lattice paths in plane. We show that for well-balanced binary strings with a ₁ ≤ a ₂ ≤  . . . ≤  a _r , the number of non-crossing pairings is equal to the number of lattice paths on the plane with certain right boundary, and hence can be enumerated by differential Goncarov polynomials. For the regular binary strings S =  (1 ^k 0 ^k ) ⁿ , the number of non-crossing pairings is given by the (k + 1)-Catalan numbers. We present a simple bijective proof for this case.     

Three-Selmer groups for elliptic curves with 3-torsion

We consider a specific family of elliptic curves with rational 3-torsion subgroup. We arithmetically define 3-Selmer groups through isogeny and 3-descent maps, then associate the image of the 3-descent maps to solutions of homogeneous cubic polynomials affiliated with the elliptic curve E and an isogenous curve E′. Thanks to the work of Cohen and Pazuki, we have solubility conditions for the homogeneous polynomials. Using these conditions, we give a graphical approach to computing the size of 3-Selmer groups. Finally, we translate the conditions on graphs into a question concerning ranks of matrices and give an upper bound for the rank of the elliptic curve E by calculating the size of the Selmer groups.     

ABAB homoleptic bis(phthalocyaninato)lutetium(III) complex: toward the real octupolar cube and giant quadratic hyperpolarizability

The concept of octupolar molecules has considerably enlarged the engineering of second-order nonlinear optical materials by giving access to 2D and 3D architectures. However, if the archetype of octupolar symmetry is a cube with alternating donor and acceptor groups at the corners, no translation of this ideal structure into a real molecule has been realized to date. This may be achieved by designing a bis(phthalocyaninato)lutetium(III) double-decker complex with a crosswise ABAB phthalocyanine bearing alternating electron-donor and electron-acceptor groups. In this communication, we present the first step toward this goal with the synthesis, crystal structure determination, and measurement of the molecular first-order hyperpolarizability β by harmonic light diffusion, of an original lutetium(III) sandwich complex displaying the required ABAB-type alternation for one face of the cube. This structure is characterized by an intense absorption in the near-IR due to an intervalence transition and exhibits the highest quadratic hyperpolarizability ever reported for an octupolar molecule, √<β(2)(HLS)> = 5750 × 10(-30) esu.     

Twitter reciprocal reply networks exhibit assortativity with respect to happiness

The advent of social media has provided an extraordinary, if imperfect, ‘big data’ window into the form and evolution of social networks. Based on nearly 40 million message pairs posted to Twitter between September 2008 and February 2009, we construct and examine the revealed social network structure and dynamics over the time scales of days, weeks, and months. At the level of user behavior, we employ our recently developed hedonometric analysis methods to investigate patterns of sentiment expression. We find users’ average happiness scores to be positively and significantly correlated with those of users one, two, and three links away. We strengthen our analysis by proposing and using a null model to test the effect of network topology on the assortativity of happiness. We also find evidence that more well connected users write happier status updates, with a transition occurring around Dunbar's number. More generally, our work provides evidence of a social sub-network structure within Twitter and raises several methodological points of interest with regard to social network reconstructions.     

What Is STEM? A Discussion About Conceptions of STEM in Education and Partnerships

Educational reformation has proceeded slowly despite the many calls to improve science and mathematics for our students. The acronym STEM (science, technology, engineering, and mathematics) has been adopted by numerous programs as an important focus for renewed global competitiveness for the United States, but conceptions of what STEM entails often vary among stakeholders. This paper examines the conceptions of STEM held by faculty members from a public Research I institution in the middle of a regional “STEM movement.” Faculty members responded to two open‐ended questions: (1) What is STEM? and (2) How does STEM influence and/or impact your life? Although 72% of these faculty members possessed a relevant conception of STEM, the results suggest that they do not share a common conceptualization of STEM. Their conception is most likely based on their academic discipline or how STEM impacts their daily lives. STEM faculty members were likely to have a neutral or positive conception where non‐STEM faculty members often had negative feelings about STEM.     

Particles with spin in stationary flat spacetimes

We construct stationary flat three-dimensional Lorentzian manifolds with singularities that are obtained from Euclidean surfaces with cone singularities and closed one-forms on these surfaces. In the application to (2?+?1)-gravity, these spacetimes correspond to models containing massive particles with spin. We analyse their geometrical properties, introduce a generalised notion of global hyperbolicity and classify all stationary flat spacetimes with singularities that are globally hyperbolic in that sense. We then apply our results to (2?+?1)-gravity and analyse the causality structure of these spacetimes in terms of measurements by observers. In particular, we derive a condition on observers that excludes causality violating light signals despite the presence of closed timelike curves in these spacetimes.