全文获取类型
收费全文 | 1953篇 |
免费 | 78篇 |
国内免费 | 13篇 |
专业分类
化学 | 1148篇 |
晶体学 | 9篇 |
力学 | 58篇 |
数学 | 509篇 |
物理学 | 320篇 |
出版年
2023年 | 21篇 |
2022年 | 42篇 |
2021年 | 78篇 |
2020年 | 80篇 |
2019年 | 84篇 |
2018年 | 83篇 |
2017年 | 72篇 |
2016年 | 111篇 |
2015年 | 82篇 |
2014年 | 98篇 |
2013年 | 149篇 |
2012年 | 145篇 |
2011年 | 144篇 |
2010年 | 87篇 |
2009年 | 70篇 |
2008年 | 89篇 |
2007年 | 79篇 |
2006年 | 68篇 |
2005年 | 68篇 |
2004年 | 48篇 |
2003年 | 30篇 |
2002年 | 20篇 |
2001年 | 11篇 |
2000年 | 15篇 |
1999年 | 8篇 |
1998年 | 16篇 |
1997年 | 10篇 |
1996年 | 11篇 |
1995年 | 6篇 |
1994年 | 13篇 |
1993年 | 10篇 |
1992年 | 9篇 |
1991年 | 11篇 |
1990年 | 12篇 |
1989年 | 12篇 |
1988年 | 10篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 11篇 |
1983年 | 7篇 |
1982年 | 11篇 |
1981年 | 11篇 |
1980年 | 12篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 10篇 |
1974年 | 7篇 |
1969年 | 4篇 |
排序方式: 共有2044条查询结果,搜索用时 546 毫秒
71.
Nguyen Huy Thuan Ramesh Prasad Pandey Ta Thi Thu Thuy Je Won Park Jae Kyung Sohng 《Applied biochemistry and biotechnology》2013,171(8):1956-1967
Myricetin is an important flavonol whose medically important properties include activities as an antioxidant, anticarcinogen, and antimutagen. The solubility, stability, and other biological properties of the compounds can be enhanced by conjugating aglycon with sugar moieties. The type of sugar moiety also plays a significant role in the biological and physical properties of the natural product glycosides. Reconstructed Escherichia coli containing thymidine diphosphate-α-l-rhamnose sugar gene cassette and Arabidopsis-derived glycosyltransferase were used for rhamnosylation of myricetin. Myricetin (100 μM) was exogenously supplemented to induced cultures of engineered E. coli. The formation of target product—myricetin-3-O-α-l-rhamnoside—was confirmed by chromatographic and NMR analyses. The yield of product was improved by using various mutants and methylated cyclodextrin as a molecular carrier for myricetin in combination with E. coli M3G3. The maximal yield of product is 55.6 μM (3.31-fold higher than the control E. coli MG3) and shows 55.6 % bioconversion of substrate under optimized conditions. 相似文献
72.
73.
Binh Khanh Mai Prof. Yongho Kim 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(11):3568-3572
74.
Thien Y Vu Prof. Anna Chrostowska Prof. Thi Kieu Xuan Huynh Prof. Saïd Khayar Prof. Alain Dargelos Katarzyna Justyna Dr. Beata Pasternak Prof. Stanisław Leśniak Prof. Curt Wentrup 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(44):14983-14988
Thermal reactions of N‐benzylidene‐ and N‐(2‐pyridylmethylidene)‐tert‐butylamines ( 5 and 13 ) under FVT conditions have been investigated. Unexpectedly, at 800 °C, compound 5 yields 1,2‐dimethylindole and 3‐methylisoquinoline. In the reaction of 13 at 800 °C, 3‐methylimidazo[1,5‐a]pyridine was obtained as the major product. Mechanisms of these reactions have been proposed on the basis of DFT calculations. Furthermore, UV‐photoelectron spectroscopy combined with FVT has been applied for direct monitoring and characterization of the thermolysis products in situ. 相似文献
75.
Rod-like cellulose nanowhiskers and spherical cellulose nanoparticles were prepared from wood-pulp-derived cellulose powder by mechanical refining processes such as high-pressure homogenization (HPH) and ball-milling (BM). The nanowhiskers obtained by the HPH method were found to be 200–500 nm long and 11–16 nm wide. The diameters of the nanoparticles were in the range 40–200 nm, depending on the BM time, and were reduced to 25–50 nm after extra HPH. By adjusting the BM time, cellulose nanoparticles having different polymorphs with similar morphologies were prepared. The X-ray diffraction patterns revealed the recrystallization of cellulose I (1 h of BM time) or cellulose II (4–8 h of BM time) in ball-milled nanoparticles after water washing and solvent exchange treatments. The nanowhisker widths derived from the specific surface areas (SSA) by adsorption methods such as Congo red dye, nitrogen, and water vapor, sorptions were in agreement with those obtained from transmission electron microscopy and atomic force microscopy images. Similar SSA values were obtained for micro- and nano-scale cellulose materials using water vapor adsorption methods, and the SSAs of nanoparticles obtained by different adsorption methods are also discussed. 相似文献
76.
77.
Specific ion effects on the electrophoretic mobility of small,highly charged peptides: A modeling study 下载免费PDF全文
Stuart A. Allison Hengfu Wu Tuyen M. Bui Lac Dang Giang H. Huynh Tam Nguyen Linda Soegiarto Bi C. Truong 《Journal of separation science》2014,37(17):2403-2410
In this work, we use coarse‐grained modeling to study the free solution electrophoretic mobility of small highly charged peptides (lysine, arginine, and short oligos thereof (up to nonapeptides)) in NaCl and Na2SO4 aqueous solutions at neutral pH and room temperature. The experimental data are taken from the literature. A bead modeling methodology that treats the electrostatics at the level of the nonlinear Poisson Boltzmann equation developed previously in our laboratory is able to account for the mobility of all peptides in NaCl, but not Na2SO4. The peptide mobilities in Na2SO4 can be accounted for by including sulfate binding in the model and this is proposed as one possible explanation for the discrepancy. Oligo arginine peptides bind more sulfate than oligo lysines and sulfate binding increases with the oligo length. 相似文献
78.
Duy-Khiem Nguyen Chau Ha-Thu Ngoc Le Phuong Thi Nguyen 《Green Chemistry Letters and Reviews》2014,7(2):167-173
A novel and time-saving method to prepare a Brønsted acidic ionic liquid, 1-carboxymethyl-3-methylimidazolium hydrogen sulfate ([CMI][HSO4]), in high yield and purity was performed under microwave irradiation. The ionic liquid showed an incomparable catalytic efficiency in the microwave-accelerated esterification of arenecarboxylic acids. Moreover, its ability of being recovered and reused many times without loss of activity has made [CMI][HSO4] more favorable from the viewpoint of green chemistry. 相似文献
79.
Dr. Thi Minh Thi Le Dr. Thibaud Brégent Prof. Dr. Philippe Jubault Prof. Dr. Thomas Poisson 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(52):e202201514
Herein, we disclosed the contra-thermodynamic E→Z isomerization of alkenyl silanes, according to the in situ formation of a chromophoric species, in the presence of rac-BINAP as the catalyst. The reaction carried out in DMSO or CH3CN under irradiation at 405 nm allowed the interconversion of the E-isomers into the Z-congeners in good to excellent yields and outstanding Z/E selectivities, on 18 examples. Finally, the mechanism of this E→Z isomerization was studied to get insight into the reaction mechanism. 相似文献
80.
Thi Thanh Hanh Nguyen Jong-Hyun Jung Min-Kyu Kim Sangyong Lim Jae-Myoung Choi Byoungsang Chung Do-Won Kim Doman Kim 《Molecules (Basel, Switzerland)》2021,26(7)
The main protease (Mpro) is a major protease having an important role in viral replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus that caused the pandemic of 2020. Here, active Mpro was obtained as a 34.5 kDa protein by overexpression in E. coli BL21 (DE3). The optimal pH and temperature of Mpro were 7.5 and 37 °C, respectively. Mpro displayed a Km value of 16 μM with Dabcyl-KTSAVLQ↓SGFRKME-Edans. Black garlic extract and 49 polyphenols were studied for their inhibitory effects on purified Mpro. The IC50 values were 137 μg/mL for black garlic extract and 9–197 μM for 15 polyphenols. The mixtures of tannic acid with puerarin, daidzein, and/or myricetin enhanced the inhibitory effects on Mpro. The structure–activity relationship of these polyphenols revealed that the hydroxyl group in C3′, C4′, C5′ in the B-ring, C3 in the C-ring, C7 in A-ring, the double bond between C2 and C3 in the C-ring, and glycosylation at C8 in the A-ring contributed to inhibitory effects of flavonoids on Mpro. 相似文献