A High-Performance Thin-Layer Chromatographic Method for the Evaluation of Marmelosin from Aegle marmelos Corr. Extract and Its Traditional Formulation from Rat Plasma: Application to Pharmacokinetics

JPC – Journal of Planar Chromatography – Modern TLC - Marmelosin is one of the major phytochemical constituents of Aegle marmelos (L.) Corr. (Rutaceae). Till date, there are no methods...     

Structurally Stabilized Organosilane‐Templated Thermostable Mesoporous Titania

Structurally thermostable mesoporous anatase TiO₂ (m‐TiO₂) nanoparticles, uniquely decorated with atomically dispersed SiO₂, is reported for the first time. The inorganic Si portion of the novel organosilane template, used as a mesopores‐directing agent, is found to be incorporated in the pore walls of the titania aggregates, mainly as isolated sites. This is evident by transmission electron microscopy and high‐angle annular dark field scanning transmission electron microscopy, combined with electron dispersive X‐ray spectroscopy. This type of unique structure provides exceptional stability to this new material against thermal collapse of the mesoporous structure, which is reflected in its high surface area (the highest known for anatase titania), even after high‐temperature (550 °C) calcination. Control of crystallite size, pore diameter, and surface area is achieved by varying the molar ratios of the titanium precursor and the template during synthesis. These mesoporous materials retain their porosity and high surface area after template removal and further NaOH/HCl treatment to remove silica. We investigate their performance for dye‐sensitized solar cells (DSSCs) with bilayer TiO₂ electrodes, which are prepared by applying a coating of m‐TiO₂ onto a commercial titania (P25) film. The high surface area of the upper mesoporous layer in the P25–m‐TiO₂ DSSC significantly increases the dye loading ability of the photoanode. The photocurrent and fill factor for the DSSC with the bilayer TiO₂ electrode are greatly improved. The large increase in photocurrent current (ca. 56 %) in the P25–m‐TiO₂ DSSC is believed to play a significant role in achieving a remarkable increase in the photovoltaic efficiency (60 %) of the device, compared to DSSCs with a monolayer of P25 as the electrode.     

Development of 99Mo-alfa-benzoin oxime complex as industrial radiotracer for identification of leaky heat exchanger and its validation with 99mTc

Journal of Radioanalytical and Nuclear Chemistry - In the traditional medicine of Iran, some herbal medicines are used for treating of high blood sugar. In this study, the concentration of Ca, Cr,...     

A quick and regioselective access of spirooxindole-oxazoline by reaction of isatin and isocyanoacetate “on water”

A greener, rapid and regioselective “on water” synthesis of spirooxindole-oxazoline by the reaction of isatin and isocyanoacetate at room temperature is described. The developed protocol has the advantage of being atom-economical, eco-friendly, and benign reaction conditions. Broader substrate scope, experimentally simple procedures, and easy purification of products with high yield further make this method attractive. The synthesized compounds have been fully characterized with spectral analysis.     

Formation and Structure of Fluorescent Silver Nanoclusters at Interfacial Binding Sites Facilitating Oligomerization of DNA Hairpins

Fluorescent, DNA‐stabilized silver nanoclusters (DNA‐AgNCs) are applied in a range of applications within nanoscience and nanotechnology. However, their diverse optical properties, mechanism of formation, and aspects of their composition remain unexplored, making the rational design of nanocluster probes challenging. Herein, a synthetic procedure is described for obtaining a high yield of emissive DNA‐AgNCs with a C‐loop hairpin DNA sequence, with subsequent purification by size‐exclusion chromatography (SEC). Through a combination of optical spectroscopy, gel electrophoresis, inductively coupled plasma mass spectrometry (ICP‐MS), and small‐angle X‐ray scattering (SAXS) in conjunction with the systematic study of various DNA sequences, the low‐resolution structure and mechanism of the formation of AgNCs were investigated. Data indicate that fluorescent DNA‐AgNCs self‐assemble by a head‐to‐head binding of two DNA hairpins, bridged by a silver nanocluster, resulting in the modelling of a dimeric structure harboring an Ag₁₂ cluster.     

A ghost fluid Lattice Boltzmann method for complex geometries

A ghost fluid Lattice Boltzmann method (GF‐LBM) is developed in this study to represent complex boundaries in Lattice Boltzmann simulations of fluid flows. Velocity and density values at the ghost points are extrapolated from the fluid interior and domain boundary via obtaining image points along the boundary normal inside the fluid domain. A general bilinear interpolation algorithm is used to obtain values at image points which are then extrapolated to ghost nodes thus satisfying hydrodynamic boundary conditions. The method ensures no‐penetration and no‐slip conditions at the boundaries. Equilibrium distribution functions at the ghost points are computed using the extrapolated values of the hydrodynamic variables, while non‐equilibrium distribution functions are extrapolated from the interior nodes. The method developed is general, and is capable of prescribing Dirichlet as well as Neumann boundary conditions for pressure and velocity. Consistency and second‐order accuracy of the method are established by running three test problems including cylindrical Couette flow, flow between eccentric rotating cylinders and flow over a cylinder in a confined channel. Copyright © 2011 John Wiley & Sons, Ltd.     

Majumdar-Papapetrou class of nonstatic cylindrically symmetric Brans-Dicke-Maxwell fields

We have obtained relations between certain components of the metric and the electromagnetic potentials for source-free Brans-Dicke-Maxwell fields described by a nonstatic cylindrically symmetric Einstein-Rosen metric. These are important, in the sense that they generate a class of solutions that in a way can be said to belong to the class generated by similar relations obtained by Majumdar [1] and Papapetrou [2] for generalized static Einstein-Maxwell fields. The relations have further been used to reduce the B-D Maxwell equations to B-D vacuum equations and vice versa.     

An efficient evolutionary multi-objective framework for MEMS design optimisation: validation, comparison and analysis

The application of multi objective evolutionary algorithms (MOEA) in the design optimisation of microelectromechanical systems (MEMS) is of particular interest in this research. MOEA is a class of soft computing techniques of biologically inspired stochastic algorithms, which have proved to outperform their conventional counterparts in many design optimisation tasks. MEMS designers can utilise a variety of multi-disciplinary design tools that explore a complex design search space, however, still follow the traditional trial and error approaches. The paper proposes a novel framework, which couples both modelling and analysis tools to the most referenced MOEAs (NSGA-II and MOGA-II). The framework is validated and evaluated through a number of case studies of increasing complexity. The research presented in this paper unprecedentedly attempts to compare the performances of the mentioned algorithms in the application domain. The comparative study shows significant insights into the behaviour of both of the algorithms in the design optimisation of MEMS. The paper provides extended discussions and analysis of the results showing, overall, that MOGA-II outperforms NSGA-II, for the selected case studies.     

Shielded suspended dielectric guide

The dispersion characteristics of a shielded suspended dielectric are computed using mode matching technique. From the dispersion characteristics the dielectric and conductor loss, quality factor and wave impedances are derived. The dimensions of shielded suspended dielectric are same as that of a rectangular metallic wave guide at K_a band.     

Synthesis of the C10–C24 fragment of (+)-cannabisativine

The stereoselective synthesis of the C10–C24 fragment of (+)-cannabisativine has been achieved. The key steps involved in this strategy are the Sharpless asymmetric dihydroxylation, the diastereoselective allylation of an imine, and the ring closing metathesis (RCM).