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101.
Parrott MC Finniss M Luft JC Pandya A Gullapalli A Napier ME DeSimone JM 《Journal of the American Chemical Society》2012,134(18):7978-7982
Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm × 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water-soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and, therefore, the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months. 相似文献
102.
Friesen BA Bhattarai A Mazur U Hipps KW 《Journal of the American Chemical Society》2012,134(36):14897-14904
For the first time, the pressure and temperature dependence of a chemical reaction at the solid/solution interface is studied by scanning tunneling microscopy (STM), and thermodynamic data are derived. In particular, the STM is used to study the reversible binding of O(2) with cobalt(II) octaethylporphyrin (CoOEP) supported on highly oriented pyrolytic graphite (HOPG) at the phenyloctane/CoOEP/HOPG interface. The adsorption is shown to follow the Langmuir isotherm with P(1/2)(298K) = 3200 Torr. Over the temperature range of 10-40 °C, it was found that ΔH(P) = -68 ± 10 kJ/mol and ΔS(P) = -297 ± 30 J/(mol K). The enthalpy and entropy changes are slightly larger than expected based on solution-phase reactions, and possible origins of these differences are discussed. The big surprise here is the presence of any O(2) binding at room temperature, since CoOEP is not expected to bind O(2) in fluid solution. The stability of the bound oxygen is attributed to charge donation from the graphite substrate to the cobalt, thereby stabilizing the polarized Co-O(2) bonding. We report the surface unit cell for CoOEP on HOPG in phenyloctane at 25 °C to be A = (1.46 ± 0.1)n nm, B = (1.36 ± 0.1)m nm, and α = 54 ± 3°, where n and m are unknown nonzero non-negative integers. 相似文献
103.
Bipul Das K. Mandal Pintu Sen Ashish Bakshi Pradip Das 《Physica B: Condensed Matter》2012,407(18):3767-3773
Room temperature magnetization of two dimensional (2D) arrays of cobalt nanowires (NWs) having diameter 50 and 150 nm prepared by electrodeposition are studied in details. Diffraction patterns of the NWs reveal that the crystallites of the NWs become more textured on decreasing their diameter. Magnetic hysteresis loop measurements show the magnetic easy axis changes its direction from axial to perpendicular direction of NWs on increasing the length of the NWs. The magnetostatic interaction among the NWs, known as the key factor in defining the easy direction is found not to be dipolar at all the circumstances. An aspect ratio (length/diameter of NWs) dependence of the non-dipolar interaction in 150 nm NWs is evident from the static magnetization as well as from ferromagnetic resonance (FMR) measurements. 相似文献
104.
Nirupam Das Biswajit Dash Meenakshi Dhanawat Sushant Kumar Shrivastava 《Chemical Papers》2012,66(1):67-74
Ten derivatives of N1 substituted/unsubstituted 5-(4-chlorophenyl)-3-(2-thienyl) pyrazoline were synthesised from chalcone-like
intermediate and substituted phenyl hydrazines, hydrazine hydrate, and semi/thiosemicarbazide. The chemical structure of compounds
was confirmed by means of IR, 1H NMR, mass spectroscopy, and elemental analysis. The antidepressant and anticonvulsant activities were investigated by Porsolt’s
behavioural despair test (forced swimming) and maximum electroshock seizure test, respectively. Rota-Rod test was performed
to assess any probable changes in motor coordination induced by the test compounds. Four compounds (IId, IIg, IIi, and IIj) exhibited good activity profile against depression and docking studies confirmed their consensual interaction with monoamine
oxidase A. In addition, compounds IIc and IIe showed protection against MES-induced seizures. 相似文献
105.
The theory of Tuncay and Corapcioglu (Transp Porous Media 23:237–258, 1996a) has been employed to investigate the possibility
of plane wave propagation in a fractured porous medium containing two immiscible fluids. Solid phase of the porous medium
is assumed to be linearly elastic, isotropic and the fractures are assumed to be distributed isotropically throughout the
medium. It has been shown that there can exist four compressional waves and one rotational wave. The phase speeds of these
waves are found to be affected by the presence of fractures, in general. Of the four compressional waves, one arises due to
the presence of fractures in the medium and the remaining three are those encountered by Tuncay and Corapcioglu (J Appl Mech
64:313–319, 1997). Reflection and transmission phenomena at a plane interface between a uniform elastic half-space and a fractured
porous half-space containing two immiscible fluids, are analyzed due to incidence of plane longitudinal/transverse wave from
uniform elastic half-space. Variation of modulus of amplitude and energy ratios with the angle of incidence are computed numerically
by taking the elastic half-space as granite and the fractured porous half-space as sandstone material containing non-viscous
wetting and non-wetting fluid phases. The results obtained in case of porous half-space with fractures, are compared graphically
with those in case of porous half-space without fractures. It is found that the presence of fractures in the porous half-space
do affect the reflection/transmission of waves, which is responsible for raising the reflection and lowering the transmission
coefficients. 相似文献
106.
Haolin Zhu Ashish Dhall Subrata Mukherjee Ashim K. Datta 《Transport in Porous Media》2010,84(2):335-369
A thermomechanical theory for multiphase transport in unsaturated swelling porous media is developed on the basis of Hybrid
Mixture Theory (saturated systems can also be modeled as a special case of this general theory). The aim is to comprehensively
and non-empirically describe the effect of viscoelastic deformation on fluid transport (and vice versa) for swelling porous
materials. Three phases are considered in the system: the swelling solid matrix s, liquid l, and air a. The Coleman–Noll procedure is used to obtain the restrictions on the form of the constitutive equations. The form of Darcy’s
law for the fluid phase, which takes into account both Fickian and non-Fickian transport, is slightly different from the forms
obtained by other researchers though all the terms have been included. When the fluid phases interact with the swelling solid
porous matrix, deformation occurs. Viscoelastic large deformation of the solid matrix is investigated. A simple form of differential-integral
equation is obtained for the fluid transport under isothermal conditions, which can be coupled with the deformation of the
solid matrix to solve for transport in an unsaturated system. The modeling theory thus developed, which involves two-way coupling
of the viscoelastic solid deformation and fluid transport, can be applied to study the processing of biopolymers, for example,
soaking of foodstuffs and stress-crack predictions. Moreover, extension and modification of this modeling theory can be applied
to study a vast variety of problems, such as drying of gels, consolidation of clays, drug delivery, and absorption of liquids
in diapers. 相似文献
107.
Dhruba Gupta C Samanta R Kanungo P Basu Subinit Roy S Kailas A Chatterjee B J Roy K Mahata A Samant A Shrivastava 《Pramana》2001,57(1):209-213
Inclusive cross sections of α particles and tritons from the breakup of 42 MeV 7Li by 12C and 197Au targets are presented and analysed in the framework of the Serber model. Spectral distortions due to the targets and relevant
reaction mechanisms are discussed. 相似文献
108.
Purnima Shrivastava 《PAMM》2007,7(1):2150043-2150044
Simulating the heat conduction in between a solid conducting body immersed in fluid at a given temperature is a difficult task, particularly when the body is tapered in shape and the costs have to be kept low. The body in question is cylindrical, symmetrical about z-axis, tapered in shape and has been heated to a high temperature before being immersed into the fluid. The heat conduction equation in cylindrical polar coordinates with all derivative boundary conditions is attempted to be solved in two ways – first analytically making use of Bessel's function and then by numerical modelling with the help of Finite Difference method, and equations thus formed have been solved through ADI explicit and Implicit (Peaceman Rachford) scheme on microcomputer. The paper is an account of work already done on this and includes further possibilities for general solution with analytical methods and a suitable low-cost numerical solution. Also possible analogy with flow of fluids have been explored. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
109.
Ashish Kaul Raviprasad Kuthethur Yoshiyuki Ishida Keiji Terao Renu Wadhwa Sunil C. Kaul 《Molecules (Basel, Switzerland)》2022,27(1)
Propolis, also known as bee-glue, is a resinous substance produced by honeybees from materials collected from plants they visit. It contains mixtures of wax and bee enzymes and is used by bees as a building material in their hives and by humans for different purposes in traditional healthcare practices. Although the composition of propolis has been shown to depend on its geographic location, climatic zone, and local flora; two largely studied types of propolis: (i) New Zealand and (ii) Brazilian green propolis have been shown to possess Caffeic Acid Phenethyl Ester (CAPE) and Artepillin C (ARC) as the main bioactive constituents, respectively. We have earlier reported that CAPE and ARC possess anticancer activities, mediated by abrogation of mortalin-p53 complex and reactivation of p53 tumor suppressor function. Like CAPE, Artepillin C (ARC) and the supercritical extract of green propolis (GPSE) showed potent anticancer activity. In this study, we recruited low doses of GPSE and ARC (that did not affect either cancer cell proliferation or migration) to investigate their antistress potential using in vitro cell based assays. We report that both GPSE and ARC have the capability to disaggregate metal- and heat-induced aggregated proteins. Metal-induced aggregation of GFP was reduced by fourfold in GPSE- as well as ARC-treated cells. Similarly, whereas heat-induced misfolding of luciferase protein showed 80% loss of activity, the cells treated with either GPSE or ARC showed 60–80% recovery. Furthermore, we demonstrate their pro-hypoxia (marked by the upregulation of HIF-1α) and neuro-differentiation (marked by differentiation morphology and upregulation of expression of GFAP, β-tubulin III, and MAP2). Both GPSE and ARC also offered significant protection against oxidative stress and, hence, may be useful in the treatment of old age-related brain pathologies. 相似文献
110.
Jerry A. Darsey Ashish G. Soman Don W. Noid 《Macromolecular theory and simulations》1993,2(5):711-719
In this work, a neural network was used to learn features in potential energy surfaces and relate those features to conformational properties of a series of polymers. Specifically, we modeled Monte Carlo simulations of 20 polymers in which we calculated the characteristic ratio and the temperature coefficient of the characteristic ratio for each polymer. We first created 20 rotational potential energy surfaces using MNDO procedures and then used these energy surfaces to produce 10000 chains, each chain 100 bonds long. From these results we calculated the mean-square end-to-end distance, the characteristic ratio and its corresponding temperature coefficient. A neural network was then used to model the results of these Monte Carlo calculations. We found that artificial neural network simulations were highly accurate in predicting the outcome of the Monte Carlo calculations for polymers for which it was not trained. The overall average error for prediction of the characteristic ratio was 4,82%, and the overall average error for prediction of the temperature coefficient was 0,89%. 相似文献