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71.
Sandra Schl?gl Nicolai Aust Raimund Schaller Armin Holzner Wolfgang Kern 《Monatshefte für Chemie / Chemical Monthly》2010,79(7):1365-1372
Abstract
Latex allergies arise from the presence of latex proteins as well as noxious rubber additives (mainly accelerators and activators used in conventional sulfur-accelerated vulcanization processes) in medical devices (e.g., medical gloves, catheters) made from natural rubber latex. As a new approach the ultraviolet (UV) light-initiated pre-vulcanization of natural rubber latex makes efficient cross-linking feasible without using any toxic, mutagenic, or irritating chemicals. The cross-linking in the latex particles is accomplished via the thiol-ene addition reaction in the presence of a polyfunctional thiol and a photoinitiator. The new process is carried out in a falling film photoreactor on a pilot scale which provides a continuous irradiation of the latex emulsion. The UV technique is suitable for an easy up-scaling and represents the entrance into large-volume industrial production. The surgical gloves are then made by a conventional coagulant dipping process comprising good physical properties and high ageing stabilities. The aim of this study was to evaluate the biological properties and skin compatibility of UV-pre-cured gloves in skin sensitization, skin irritation studies, and cytotoxic tests. In addition the biologically available chemical residues in the gloves were characterized by UV–visible spectroscopy, elementary analyses, and high-performance liquid chromatography coupled with mass spectroscopy. The results of the studies revealed that UV-cross-linked surgical gloves exhibit good skin compatibility together with low cytotoxicity and residual chemical levels in the range of 60 and 120 μg/gglove. 相似文献72.
Ali A. Mohammadi Armin Hadadzahmatkesh Mohammad R. Asghariganjeh 《Monatshefte für Chemie / Chemical Monthly》2012,124(5):931-933
Abstract
FeNH4(SO4)2·12H2O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines. The work-up is easy, and the products are obtained in good to excellent yields and high purity. 相似文献73.
Claudia Strobel Adriano A. Torrano Rudolf Herrmann Marcelina Malissek Christoph Bräuchle Armin Reller Lennart Treuel Ingrid Hilger 《Journal of nanoparticle research》2014,16(1):1-16
Until now, the potential effects of titanium dioxide (TiO2) nanoparticles on endothelial cells are not well understood, despite their already wide usage. Therefore, the present work characterizes six TiO2 nanoparticle samples in the size range of 19 × 17 to 87 × 13 nm, which are commonly present in sun protection agents with respect to their physicochemical properties (size, shape, ζ-potential, agglomeration, sedimentation, surface coating, and surface area), their interactions with serum proteins and biological impact on human microvascular endothelial cells (relative cellular dehydrogenase activity, adenosine triphosphate content, and monocyte chemoattractant protein-1 release). We observed no association of nanoparticle morphology with the agglomeration and sedimentation behavior and no variations of the ζ-potential (?14 to ?19 mV) in dependence on the surface coating. In general, the impact on endothelial cells was low and only detectable at concentrations of 100 μg/ml. Particles containing a rutile core and having rod-like shape had a stronger effect on cell metabolism than those with anatase core and elliptical shape (relative cellular dehydrogenase activity after 72 h: 60 vs. 90 %). Besides the morphology, the nanoparticle shell constitution was found to influence the metabolic activity of the cells. Upon cellular uptake, the nanoparticles were localized perinuclearly. Considering that in the in vivo situation endothelial cells would come in contact with considerably lower nanoparticle amounts than the lowest-observable adverse effects level (100 μg/ml), TiO2 nanoparticles can be considered as rather harmless to humans under the investigated conditions. 相似文献
74.
The acyclic dehydrotrimer (12) and -hexamer (28) of 1,1-diethynyl-2,2,3,3-tetramethylcyclopropane were prepared from 1-chloro-1-(trimethylsilylethynyl)-2,2,3,3-tetramethylcyclopropane (4) in six and nine steps, respectively, in 36 and 8 % overall yield, respectively, using Cadiot-Chodkiewicz or Hay coupling procedures as key steps. Mono-tert-butyldimethylsilyl (TBDMS) protection of the acyclic dehydrotrimer (20) and -hexamer (23) of 1,1-diethynylcyclopropane followed by Hay coupling and protiodesilylation furnished the acyclic dehydrohexamer (23) and -dodecamer (29) in 35 and 56 % overall yield, respectively. Subsequent cyclizing oxidative dimerization of 12 or cyclization of 28 using a modified Glaser protocol produced the first completely permethylspirocyclopropanated macrocyclic oligodiacetylene, compound 30 in 49 and 21 % yield, respectively. The cyclic dehydrohexa- (31) and dehydrododecamer (32) have been prepared from 23 and 29 in 49 and 7 % yield by applying the same protocol. The macrocycle 32 is particularly interesting in that it contains 60 carbon atoms in the inner ring, and indeed a decomposition mode consecutively cleaving off ethylene units from it as well as from 31 and tetramethylethylene from the permethylated exp-[6]rotane 30 has been proved by differential scanning calorimetry with evolved gas analysis. The thermal decomposition of these "exploding" [6]rotanes 31 and 30 set on at 100 and 135 degrees C, respectively, and release energies of 478 and 285 kcal. mol(-1), respectively, significantly more than the energy release of the explosive hexogen with 143 kcal mol(-1). 相似文献
75.
A hexapeptide assembled from dipeptide building blocks assumes the secondary structure of the polyproline II (PPII) helix. Side chain-to-backbone hydrogen bonds stabilize peptide torsions next to the fused ring systems. The solution structure of the polyhydroxylated peptide was studied by spectroscopic methods. 相似文献
76.
A numerical simulation of attosecond harmonic pulse generation in a three-dimensional field-ionizing gas is presented. Calculated harmonic efficiencies quantitatively reproduce experimental findings. This allows a quantitative characterization of attosecond pulse generation revealing information currently not accessible by experiment. The rapid phase variation and spatiotemporal distortions of harmonics are smaller than anticipated, allowing focusing of 30-nm, 750-as pulses to intensities in excess of 10(13) W/cm(2). Feasibility of such pulses brings novel applications such as extreme ultraviolet nonlinear optics and attosecond pump probe spectroscopy within reach. 相似文献
77.
78.
Armin Lambacher Peter Fromherz 《Applied Physics A: Materials Science & Processing》1996,63(3):207-216
A silicon chip is covered by a monomolecular film of a fluorescence dye with silicon dioxide used as a spacer. The fluorescence depends on the distance of the dye from the silicon. The modulation of the intensity is described quantitatively by an optical theory which accounts for interference of the exciting light and of the emitted light. The effect is used to obtain a microscopic picture of the surface profile with a precision of a few Angströms. The perspectives for an application in wet systems such as neuron-silicon junctions and lipid membranes on silicon are pointed out. 相似文献
79.
80.