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31.
Anna Tramontano 《Physics of life reviews》2004,1(2):103-127
The availability of the complete genomic sequences of many species, including human, has raised enormous expectations in medicine, pharmacology, ecology, biotechnology and forensic sciences. However, knowledge is only a first step toward understanding, and we are only at the early stage of a scientific process that might lead us to satisfy all the expectations raised by the genomic projects. In this review I will discuss the present status of computational methods that attempt to infer the unique three-dimensional structure of proteins from their amino acid sequences. Although this problem has been defined as the “holy grail” of biology, it represents only one of the many hurdles in our path towards the understanding of life at a molecular level. 相似文献
32.
Anna Jenčová 《International Journal of Theoretical Physics》2004,43(7-8):1635-1649
We use a class of generalized relative entropies on density matrices to obtain one-parameter families of torsion-free affine connections. 相似文献
33.
Maria G. Semenova Larisa E. Belyakova Anna S. Antipova Yu. N. Polikarpov Lida Klouda Anna Markovic Michael M. Il'in 《Colloids and surfaces. B, Biointerfaces》2003,31(1-4):47-54
We report on the effect of commercially important polysaccharides (maltodextrins with variable dextrose equivalent (Paselli SA-2, MD-6 and MD-10) on the surface activity at the air–water interface of small-molecule surfactants (sms), possessing different hydrophobic–lipophilic balance ((SSL (Na+), the main component is a sodium salt of stearol–lactoyl lactic acid, and PGE (080), polyglycerol ester of C18 fatty acid), and widely used in food products. A marked change of the surface activity of sms was found in the presence of maltodextrins by tensiometry. The combined data of laser multiangle light scattering and mixing calorimetry have suggested that this result is governed by specific complex formation between maltodextrins and sms in aqueous medium. Measurements have been made of the molar mass, the second virial coefficient and the enthalpy of intermolecular interactions in aqueous solutions. The implication of a degree of polymerization of maltodextrins in this phenomenon was shown. The interrelation between the molecular parameters of the formed complexes and their surface activity at the air–water interface has been revealed and discussed. 相似文献
34.
In this paper a tripartite qualitative design combining abservation, stimulated recall and interview is presented and discussed. This three-step-design makes it possible to get insight into the interaction of internal and external processes when solving mathematical tasks. The data analysis depends on the research question and the methodological approach. In the light of two research projects in mathematics education two different methods of data analysis are presented and methodologically reflected. 相似文献
35.
Anna Avallone 《Mathematica Slovaca》2007,57(2):129-140
We prove the existence of separating points for every countable family of nonatomic σ-additive modular measures on a σ-complete lattice ordered effect algebra.
相似文献
36.
Anna Canale 《Journal of Mathematical Analysis and Applications》2003,287(1):101-117
In unbounded domains we state some a priori bounds for solutions of the Dirichlet problem for linear second order elliptic differential equations in nondivergence form with discontinuous coefficients in weighted spaces. The weight function is related to the distance function from a fixed subset S of ∂Ω. 相似文献
37.
Kathryn A. Downsland Anna M. Greaves 《The Journal of the Operational Research Society》1994,45(7):817-826
The use of a bi-directional, as opposed to a one-way, transportation system, can increase the operational efficiency of automated guided vehicles in both manufacturing and warehousing environments. However, the full potential will only be realized if the routeing algorithms pay particular attention to the problem of collision avoidance. This paper is concerned with the development of such an algorithm. The method is based on the use of delays and deviations to avoid collisions that could arise when using the shortest routes for each vehicle, and is applicable to any transportation system which can be represented as a network with known travel times. 相似文献
38.
Marta Gimnez-Pedrs Ali Aghmiz Carmen Claver Anna M. Masdeu-Bult Denis Sinou 《Journal of molecular catalysis. A, Chemical》2003,200(1-2):157-163
High linear alkenes (1-octene and 1-decene) have been hydroformylated using water-soluble rhodium complexes associated with sulfonated diphosphines in the presence of ionic surfactants or methanol. In all cases, the hydroformylation activities were higher than in experiments without additives. The selectivity in aldehydes was higher when we used cetyltrimethylammonium hydrogensulfate (CTAHSO4) as the surfactant or methanol as the co-solvent. 相似文献
39.