Synthesis of crescent shaped heterocycle-fused aromatics via Garratt-Braverman cyclization and their DNA-binding studies

Three crescent shaped heterocycle-fused phenanthrene based systems 1–3 have been synthesized starting from benzene (or substituted benzene) 1,2-bis-propargyl alcohols. Bis-alkylation with propargylic bromides provided the key intermediate, the bis-propargyl bis-ethers. In spite of the possibility of many competing reactions, the latter underwent facile double Garratt-Braverman cyclization to provide compounds 1–3 in near quantitative yield, in a striking reaction involving the formation of four C–C bonds in a single step. Compounds 1–3 showed binding interaction with DNA, predominantly, via groove binding along with partial intercalation (combilexins). Molecular docking study supported the proposed binding modes.     

Multiscale data sampling and function extension

We introduce a multiscale scheme for sampling scattered data and extending functions defined on the sampled data points, which overcomes some limitations of the Nyström interpolation method. The multiscale extension (MSE) method is based on mutual distances between data points. It uses a coarse-to-fine hierarchy of the multiscale decomposition of a Gaussian kernel. It generates a sequence of subsamples, which we refer to as adaptive grids, and a sequence of approximations to a given empirical function on the data, as well as their extensions to any newly-arrived data point. The subsampling is done by a special decomposition of the associated Gaussian kernel matrix in each scale in the hierarchical procedure.     

Hydrogenation of Pd-capped Mg thin films prepared by DC magnetron sputtering

Structural and optical properties of pure Mg thin film coated with Pd have been investigated. Pd-capped Mg thin films had been prepared by DC magnetron sputtering. This work presents an ex situ study on hydrogenation and dehydrogenation kinetics of Pd/Mg films at different conditions using XRD, AFM and optical spectrophotometer. We have succeeded to load thin films of Mg to MgH₂ at normal temperature and normal pressure of hydrogen gas. In hydrogenation, α-MgH₂ phase of magnesium hydride was observed in hydrogenated films at 200 °C and γ-MgH₂ at 250 °C respectively. The desorption kinetics in vacuum also revealed the phase transformation α-MgH₂ to γ-MgH₂. A reflectance change was observed in hydrogenated films in comparison of as deposited thin film. Hydrogenated (H loaded) samples were observed partially transparent in comparison of as deposited.     

Performance analysis of an integrated scheme in optical burst switching high-speed networks

A new integrated scheme based on resource-reservation and adaptive network flow routing to alleviate contention in optical burst switching networks is proposed. The objective of the proposed scheme is to reduce the overall burst loss in the network and at the same time to avoid the packet out-of-sequence arrival problem. Simulations are carried out to assess the feasibility of the proposed scheme. Its performance is compared with that of contention resolution schemes based on conventional routing. Through extensive simulations, it is shown that the proposed scheme not only provides significantly better burst loss performance than the basic equal proportion and hop-length based traffic routing algorithms, but also is void of any packet re-orderings.     

A novel optical burst switching architecture for high speed networks

A novel optical burst switching （OBS） high speed network architecture has been proposed. To verify its feasibility and evaluate its performance, just-enough-time （JET） signaling has been considered as a high performance protocol. In the proposed architecture, to avoid burst losses, firstly, a short-prior- confirmation-packet （SPCP） is sent over the control channel that simulates the events that the actual packet will experience. Once SPCP detects a drop at any of the intermediate nodes, the actual packet is not sent but the process repeats. In order to increase network utilization, cost effectiveness and to overcome some limitations of conventional OBS, inherent codes （e.g., orthogonal optical codes （OOC））, which are codified only in intensity, has been used. Through simulations, it shows that a decrease in burst loss probability, cost effectiveness and a gain in processing time are obtained when optical label processing is used as compared with electronic processing.     

Jet produced by collapse of conical free surface of a metal by plane shock wave

Theoretical and experimental investigations of metal-jets, produced by interaction of a plane shock wave with a conical cavity at free surface of metals like aluminium, copper and mild steel, have been carried out and an attempt has been made to correlate the jet velocity with shock parameters. The velocity of the jet, obtained from the cavity of different half angles have been mostly measured with oscillographic technique. The experimental results agree with theory within experimental variations. The velocity of the jet increases monotonically with the particle velocity but decreases with increase in the angle of the cavity.     

Facile formation of molybdenum(VI) monooxo aryloxides MoO(OAr)4-nCln from molybdenum dioxo dichloride

Molybdenum monooxo compoundsMoO(OAr)4-nCln (n=0-2, Ar=2,6-Me2C6H3 or 2,6-i-Pr2C6H3) have been synthesized starting from the dioxo precursor MoO2Cl2. The complexes are characterized spectroscopically and by X-ray diffraction. The formation mechanism likely involves phenol precoordination followed by addition across the Mo=O bond.     

Synthesis and reactivity of enediynyl amino acids and peptides: a novel concept in lowering the activation energy of Bergman cyclisation by H-bonding and electrostatic interactions

Novel enediynyl amino acids and peptides 3 and 5-8 were synthesized and their thermal reactivity towards Bergman cyclization studied and compared with the earlier reported amino acid 4, which demonstrated, for the first time, the effect of H-bonding and electrostatic interactions in lowering the activation energy of Bergman cyclization.