A Practical Asymmetric Synthesis of A Pseudomonic Acid Precursor from D-Arabinose or D-Xylose

The asymmetric synthesis of multi-gram quantities of a pseudomonic acid precursor is described. Improvements on the literature synthesis of diacetyl arabinal from arabinose are also reported.     

A Facile Synthesis of 5-N,N-Bis(2-Hydroxyethyl)Amino-2-Thiophenecarboxaldehyde

Amination of 5-bromo-2-thiophenecarboxaldehyde with an acyclic secondary amine - bis(2-methoxyethyl)amine was effected by using weak base sodium bicarbonate. The resulting 5-N,N-bis(2-methoxyethyl)amino-2-thiophenecarboxaldehyde was treated with boron tribromide to give 5-N,N-bis(2-hydroxyethyl)amino-2-thiophenecarbox- aldehyde.     

A Comparative Study of the Lipid Composition of the Brain of Chicken and Rat During Myelination. A Chromatographic and Densitometric Analysis

JPC – Journal of Planar Chromatography – Modern TLC - The lipid profiles of brain from 10- and 18-day-old chick embryo, 1-day-old chick, and adult chicken as well as of full-term fetus...     

An isothermal titration calorimetry study of phytate binding to lysozyme

Isothermal titration calorimetry (ITC) was used to detect phytate binding to the protein lysozyme. This binding interaction was driven by electrostatic interaction between the positively charged protein and negatively charged phytate. When two phytate molecules bind to the protein, the charge on the protein is neutralised and no further binding occurs. The stoichiometry of binding provided evidence of phytate–lysozyme complex formation that was temperature dependent, being most extensive at lower temperatures. The initial stage of phytate binding to lysozyme was less exothermic than later injections and had a stoichiometry of 0.5 at 313 K, which was interpreted as phytate crosslinking two lysozyme molecules with corresponding water displacement. ITC could make a valuable in vitro assay to understanding binding interactions and complex formation that normally occur in the stomach of monogastric animals and the relevance of drinking water temperature on the extent of phytate–protein interaction. Interpretation of ITC data in terms of cooperativity is also discussed.     

Flow-SANS and Rheo-SANS applied to soft matter

We review the current literature pertaining to the characterization of soft matter subject to flow utilizing small-angle neutron scattering, flow-SANS, with an emphasis on the simultaneous measurement of the rheology, Rheo-SANS. Experimental results are discussed in terms of the flow induced structure and direct connection to the bulk rheology in which we highlight the use of the contrast match method as a unique advantage to neutron scattering techniques. Finally, we discuss specific areas in each field that could benefit from focused flow-SANS experiments, and the projected evolution of specialized flow-SANS sample environments.