Intermolecular cyclocondensation reaction of 3,4-dihydropyrimidine-2-thione under the Mitsunobu reaction conditions

A self-intermolecular cyclocondensation reaction of 3,4-dihydropyrimidine-2-thione(DHPM) to give a novel tricyclic structure containing DHPM core in the presence of diethyl azodicarboxylate(DEAD) and triphenylphosphine(TPP) at room temperature is reported.     

Expression and Characterization of the Intracellular Part of Receptor Protein Tyrosine Phosphatase PTPRU

PTPRU is an MAM domain-containing receptor-like protein tyrosine phosphatase. Previous studies have demonstrated an important role of the enzyme in the maintenance of epithelial integrity and in the regulation of the Wnt/β-catenin signaling pathway. To better understand the function of PTPRU, we cloned and expressed the intracellular portion of PTPRU as a GST fusion protein in E. coli cells. We purified the protein to homogeneity and used it to immunize mice for antibody production. The resultant antibody s...     

Structure of MgSO_4 in Concentrated Aqueous Solutions by X-Ray Diffraction

Detailed time-and-space-averaged structure of MgSO4 in the concentrated aqueous solutions was investigated via X-ray diffraction with an X’pert Pro θ-θ diffractometer at 298 K, yielding structural function and radial distribution function(RDF). The developed KURVLR program was employed for the theoretical investigation in consideration of the ionic hydration and ion association. Multi-peaks Gaussian fitting method was applied to deconvolving the overlapping bands of Differential radial distribution function...     

Synthesis of cyclicβ-silylenones via oxidative rearrangement of tertiaryα-hydroxy allylsilanes with PCC

An oxidative rearrangement of cyclic tertiary a-hydroxy allylsilanes has been carried out in refluxing ClCH₂CH₂Cl with pyridinium chlorochromate（PCC）.The reaction provides a convenient method to synthesize cyclicβ-silylenones in modest to excellent yields.     

Design and Synthesis of Chiral Molecular Tweezers Based on Deoxycholic Acid

Molecular tweezers is a novel type of artificial receptors, which not only offer the advantage of efficient construction but also their surfaces can be tailored for specific applications. The clefts of molecular tweezers are particularly effective in regard to complementarity with substrates since functional groups attached to the interior of the cleft converge on substrates held inside1. So, in recent years, the molecular tweezers receptors have attracted more and more attention in molecular …     

IMMOBILIZED CIBACRON BLUE F3G-A ON CROSSLINKED POLY(VINYL ALCOHOL) FOR AFFINITY CHROMATOGRAPHY

1. INTRODUCTION Biospecific affinity chromatography is a powerful technique for purification of proteins [1]. The biological affinity ligands in common use include enzyme substrates, inhibitors, cofactors, receptors, antibodies, etc. The advantage of these biological ligands is their very high recognition specialty for particular proteins. As a result, proteins can be purified in fewer steps, often to homogeneity, in a laboratory scale. However, scale-up of the analytical and laboratory p…     

First Total Synthesis of 5_α-Hydroxy-isopterocarpolone

Sesquiterpenic compounds of the Eudesmane family have attracted considerable attention due to their intriguing biological properties1,2, particularly significant antifeedant activity, cell growth inhibitory and plant growth regulating activities.In 1996, J. Hu and co-workers3 had isolated eudesmane sesquiterpene 5?-hydroxy-isopterocarpolone 1 from the aerial parts of chinese folk medicine Artemisia eriopoda and elucidated its structure by spectropic methods. Herein, we reported the first tota…     

On surfaces immersed in Euclidean space R~4 Dedicated to Professor Yang Lo on the Occasion of his 70th Birthday

Let M be a closed oriented surface immersed in R4 . Associated it one has the generalized Gauss map from M into the Grassmann manifold G 4,2 . This note will be concerned with the geometry of the generalized Gauss map by using the moving frame theory and the quaternion interpretation of Plcker coordinates. As one of consequences,we get the celebrated theorem of Chern and Spanier,Hoffman and Osserman,who proved it by quite different methods. At last,we give an explicit construction of a series of immersions of S2 in R4 with any given normal Euler number.     

Linearity relationship between solvatochromic shifts of stilbazolium-like dyes and modified reaction field function

We analyzed statistically the linear correlation of the solva-tochromic shifts of the stilbazolium-like dyes in the nonselected solvents with the reaction field function, L(εr) - bL( n2), and the solvent polarity parameter, ETN, respectively, and observed that there were not perfectly linearity relationships between them, so we introduced ETN into L(εr) - bL(n2) to form a new reaction field function, L(εr) - bL(n2) g ETN, called as the modified reaction field function, which can be perfectly linearly correlated with the solvatochromic shifts of the stilbazolium-like dyes in the nonselected solvents.     

Large negative Goos-H(a|¨)nchen shift from a wedge-shaped thin film

The analytical expression for the complex amplitude of light reflected from a wedge-shaped thin film is derived. For plane wave incidence, a simple ray tracing approach is used to calculate Goos-H(a|¨)nchen (GH) shifts; and for non-plane wave incidence, for example, a Gaussian beam, the angular spectrum approach of plane wave is used in simulation. The two approaches predict that a wedge-shaped thin film can produce large negative longitudinal GH shifts. Although the reflectivity is small near the condition...