Synthesis of (E)-prop-1-ene-1,3-diyldibenzene derivatives via direct decarboxylative coupling of α,β-unsaturated carboxylic acids with benzyl boronic acid pinacol ester

The first copper-catalyzed cross-coupling reaction between benzyl boronic acid pinacol ester and α,β-unsaturated carboxylic acids was described. The ready availability of the starting materials and excellent E selectivity make this protocol a safe and operationally convenient strategy for the efficient synthesis of (E)-prop-1-ene-1,3-diyldibenzene derivatives.     

ON THE NONHOLONOMIC CONSTRAINTS AND MOTION CONTROL OF WHEELED MOBILE STRUCTURES1)

当质点沿光滑曲线运动时,必须满足横向速度为零的条件.同样地,不同轮式移动结构在平面上做光滑曲线运动时都需要满足该非完整约束条件.本文结合轮子转速和它们运动速度的完整约束关系,理清各轮式移动结构的完整和非完整约束,然后利用 Euler-Lagrange 方程方便地推导出相应的动力学方程.另外,通过该非完整约束,将目标轨迹曲线转化为速度目标的形式,然后引入目标轨迹曲线的相对曲率设计合适的动态跟踪目标.进一步,通过采用该动态跟踪目标可以将轮式移动结构的运动规律和动力学方程有机结合起来,并将原运动任务简化为一般的 轨迹 控制问题.基于该动态跟踪目标可以为轮式移动结构设计合适的鲁棒跟踪控制器,通过跟踪目标轨迹曲线的相对曲率来实现对目标曲线的精确跟踪.最后,理论分析和仿真结果显示,采用动态目标跟踪方法能够从根本上解决初始速度误差过大和位置误差不断被累积的问题,即使前向速度误差系统不稳定的,实际运动轨迹也几乎能和目标轨迹曲线重合.     

纳秒光场下原子团簇产生高离化Kr离子的激光波长效应

利用不同波长和光强的纳秒激光,对Kr原子团簇进行了激光电离的飞行时间质谱研究,观察到Kr高价离子价态显著地依赖于激光波长,当分别用波长为1064,532,355和266 nm的激光照射Kr原子团簇时,可分辨的离子最高价态分别为+17,+11,+4和+2价;然而离子价态与激光功率密度的依赖关系并不明显。实验结果支持多光子电离-逆轫致吸收加热-电子碰撞电离三步电离模型,表明电子碰撞电离是高价离子产生的主要途径。     

百焦耳KrF激光器腔体的设计和激光实验

1990年原子能科学研究院建成一台百焦耳KrF激光器,最大能量输出达106焦耳。本文介绍激光器腔体主要结构参数的选定和激光实验。     

Zircon SHRIMP age of Mesoarchaean meta-argilloarenaceous rock in the Anshan area and its geological significance

In order to better understand the early continental evolution of the Anshan area, one of the typical Precambrian distribution areas of the North China Craton, the geochronology and REE composition of the zircons from the meta-argillo-arenaceous rock occurred as enclave in 3.1 Ga Lishan trondhjemite are studied by using SHRIMP II ion microprobe. It is indicated that the Paleoarchaean is a very important continental formation period in the Anshan area and 3.2 Ga can be regarded as the boundary between the Paleoarchaean and Mesoarchaean.     

红外光谱法测定酚醛树脂的羟甲基指数

介绍用红外光谱法测定酚醛树脂羟甲基指数的原理和实验条件。红外光谱积分强度法和基线法测定酚醛树脂羟甲基指数的不确定度分别为6.2%和3.2%。以红外光谱积分强度法为例，测定了ZnO催化型酚醛树脂在45℃和25℃时，其羟甲基指数随时间的变化规律。试验结果表明，该方法可以于酚醛树脂的质量控制。     

异丙肾上腺素与MnO-4的显色反应

报道了新显色剂异丙肾上腺素与MnO-4进行显色反应的最佳条件、灵敏度、选择性和界限比.建立了微量MnO-4的简便检定新方法,检出限量为0.08μg,稀释限为1∶3.8×106.实验结果表明,在pH=9.91的缓冲溶液中,最大吸收波长483.6nm处,MnO-4浓度在1.0～5.0μg/10mL范围内服从比耳定律,表观摩尔吸光系数为 1.8×105.     

Quasi-convex subsets in Alexandrov spaces with lower curvature bound

We introduce quasi-convex subsets in Alexandrov spaces with lower curvature bound, which include not only all closed convex subsets without boundary but also all extremal subsets. Moreover, we explore several essential properties of such kind of subsets including a generalized Liberman theorem. It turns out that the quasi-convex subset is a nice and fundamental concept to illustrate the similarities and differences between Riemannian manifolds and Alexandrov spaces with lower curvature bound.     

Theoretical explorations about the excited state behaviors for two novel high efficient ESIPT compounds

Structural Chemistry - Two high efficient excited state intramolecular proton transfer (ESIPT) compounds (i.e.,...     

Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles

Oxindoles and iso-oxindoles are natural product-derived scaffolds that provide inspiration for the design and synthesis of novel biologically relevant compound classes. Notably, the spirocyclic connection of oxindoles with iso-oxindoles has not been explored by nature but promises to provide structurally related compounds endowed with novel bioactivity. Therefore, methods for their efficient synthesis and the conclusive discovery of their cellular targets are highly desirable. We describe a selective Rh^III-catalyzed scaffold-divergent synthesis of spirooxindole–isooxindoles and spirooxindole–oxindoles from differently protected diazooxindoles and N-pivaloyloxy aryl amides which includes a functional group-controlled Lossen rearrangement as key step. Unbiased morphological profiling of a corresponding compound collection in the Cell Painting assay efficiently identified the mitotic kinesin Eg5 as the cellular target of the spirooxindoles, defining a unique Eg5 inhibitor chemotype.